Anaplastic oligoastrocytoma, kana anaplastic astrocytoma, ibundu rakashata reuropi. Iri kunyanya glioma, kureva bundu rinobva mutsinga, muuropi kana musana. Sangano reWorld Health Organisation rinoisa gliomas kubva paI kusvika kuIV, zvichienderana nemaitiro avo uye dhigirii rehuipi. Anaplastic astrocytomas inomiririra giredhi III, pakati pemagiredhi I neII anoonekwa seasina kunaka uye glioblastomas (giredhi IV). Anaplastic astrocytoma inogona kunge iri complication ye benign giredhi II bundu kana kukura yega. Ane tsika yakasimba yekufambira mberi kusvika glioblastoma (giredhi IV) uye tarisiro yehupenyu inosvika makore maviri kusvika matatu, zvisinei nekurapwa nekuvhiyiwa uye radiotherapy / chemotherapy. Anaplastic astrocytomas uye glioblastomas inobata 5 kusvika 8 muvanhu zana muhuwandu hwevanhu. (100)

Zvizhinji zviratidzo zveanaplastic oligoastrocytoma zvinokonzerwa nekuwedzera kudzvanywa muuropi, zvichikonzerwa nebundu pacharo kana nekusakwana kuvakwa kwecerebrospinal fluid yainokonzera. Zviratidzo zvinosiyana zvichienderana nenzvimbo uye saizi yebundu:

• Kukanganisika kwendangariro, kushanduka kwehunhu uye hemiplegia apo bundu rinokura muchikamu chemberi;
• Kubata, kukanganiswa kwendangariro, kurongeka uye kutaura kana uri mulobe yenguva;
• Kuvhiringidzika kwemotokari uye kusagadzikana kwekunzwa (kutinhira uye kupisa) kana iri parietal lobe;
• Kuvhiringidzika kunoonekwa kana bundu racho richisanganisira occipital lobe.

Chikonzero chaicho cheanaplastic astrocytoma hachisati chazivikanwa, asi vatsvakurudzi vanotenda kuti zvinokonzerwa nekusanganiswa kwemajini uye zvakatipoteredza zvinokonzera chirwere.

Anaplastic oligoastrocytoma yakati wandei kuvarume kupfuura vakadzi uye inowanzoitika pakati pemakore 30 ne50. Zvinofanira kucherechedzwa, zvisinei, kuti chirwere chinogona kubata vana, kazhinji pakati pe5 ne9 yemakore. Anaplastic astrocytomas uye multiform glioblastomas (giredhi III neIV) inomiririra ingangoita 10% yemamota ehuduku ari mukati metsinga dzetsinga (80% yemamota aya ari giredhi I kana II). (1)

Zvirwere zvenhaka zvakaita seneurofibromatosis type I (Recklinghausen's disease), Li-Fraumeni syndrome, uye Bourneville tuberous sclerosis inowedzera njodzi yekugadzira anaplastic astrocytoma.

Sezvinoita magomarara mazhinji, zvakatipoteredza zvakaita sekufumurwa nemwaranzi yeultraviolet, mwaranzi yeionizing uye mamwe makemikari, pamwe nekusadya zvakanaka uye kushushikana zvinoonekwa senjodzi.

Kurapa kweanaplastic oligoastrocytoma kunoenderana zvakanyanya nemamiriro emurwere, nzvimbo yebundu uye nekumhanya kwekufambira mberi kwaro. Inosanganisira kuvhiyiwa, radiotherapy uye chemotherapy, yega kana musanganiswa. Nhanho yekutanga ndeyekuita kuvhiyiwa kubviswa kwechikamu chikuru chebundu sezvinobvira (resection), asi izvi hazviitike nguva dzose nekuda kwezvimiro zvataurwa pamusoro apa. Mushure mekuvhiyiwa, kurapwa nemwaranzi uye pamwe chemotherapy inoshandiswa kuyedza kubvisa bundu rasara, semuenzaniso kana masero akashata akapararira mukati mehuropi.

Kufembera kwacho kwakabatana nemamiriro ehutano hwemurwere, hunhu hwebundu, uye mhinduro yemuviri kune chemotherapy neradiotherapy kurapwa. Anaplastic astrocytoma ine tsika yakasimba yekufambira mberi kune glioblastoma mukati memakore maviri. Nekurapwa kwakajairwa, nguva yepakati yekupona kwevanhu vane anaplastic astrocytoma makore maviri kusvika matatu, zvinoreva kuti hafu yavo ichafa nguva ino isati yasvika. (2)