Mukati
Zvinoenderana nebasa rayo, Iyo Edhiyo Bhodhi yeMedTvoiLokony inoedza neparinogona napo kupa yakavimbika zvekurapa zvemukati zvinotsigirwa neruzivo rwazvino rwesainzi. Mureza wekuwedzera "Zvakatariswa Zvemukati" zvinoratidza kuti chinyorwa chakaongororwa kana kunyorwa zvakananga nachiremba. Iyi nhanho-mbiri yekusimbisa: mutori wenhau wezvekurapa uye chiremba anotitendera kuti tipe zvemhando yepamusoro zvemukati zvinoenderana neruzivo rwekurapa rwazvino.
Kuzvipira kwedu munharaunda iyi kwakaongwa, pakati pevamwe, neSangano reVatori venhau vehutano, iro rakapa iyo Editorial Board yeMedTvoiLokony ine zita rekuremekedza reMudzidzisi Mukuru.
Chirwere cheAlzheimer chirwere chinonzi neurodegenerative icho chinowanzobata vanhu vakuru. Zviratidzo zvinosanganisira kukura kwedementia, matambudziko ekurangarira, kushatirwa uye kushanduka-shanduka. Chirwere cheAlzheimer hachirapike uye kazhinji chinobvisa vanhu vanorwara kubva mukushanda kwakazvimirira.
Zvikonzero zvechirwere cheAlzheimer
Kuitika kwechirwere cheAlzheimer kunobatanidzwa nezvinhu zvakasiyana-siyana: genetic, zvakatipoteredza, uye pfungwa (nguva refu yepfungwa inononoka chirwere). Kusvika pari zvino, zvisinei, chikonzero chikuru chechirwere cheAlzheimer hachisati chazivikanwa. Kune akati wandei fungidziro dzesainzi, kusanganisira shanduko muDNA inogona kubatsira pakuonekwa kwechirwere.
Chirwere cheAlzheimer chinokonzera, pakati pezvimwe zvinhu, kuvhiringidzika kwekuziva kunokonzerwa nekuvhiringidzika mukushandurwa kwechiratidzo mucholinergic system ye forebrain. Izvi zvinokanganisa zvinokonzerwa nekuderera kwecholinergic neurons (inotarisirwa kutarisa, kuyeuchidza). Mamwe ma<em>neuron anokuvadzwawo, izvo zvinoparira kusakendenga, unyengeri, utsinye, uye hunhu hunonyadzisa.
Nzira yechirwere cheAlzheimer
Chikonzero chikuru chedementia muchirwere cheAlzheimer kukuvara kwecholinergic neurons, zvisinei, yekutanga amyloid deposits inoonekwa mu glutamatergic neurons inokonzeresa kutapurirana kwehuropi, iri mu entorhinal uye associative cortex uye hippocampus. Aya maumbirwo ehuropi ane basa rekurangarira uye kuona. Ipapo iyo senile plaques inoonekwa mune cholinergic uye serotonin fibers. Sezvo chirwere ichi chichifambira mberi, huwandu hweamyloid deposits hunowedzera uye hunotungamirira mukuparara kwe glutamatergic, cholinergic, serotonin uye noradrenergic neurons.
Chirwere cheAlzheimer chinotanga zvisingaoneki uye hachina nzira yakaenzana. Inotora kubva pa5 kusvika ku12 makore. Zviratidzo zvekutanga ndezvekuyeuka uye mafungiro (kuora mwoyo uye kutuka-mumuviri). Zvadaro, matambudziko ane ndangariro nyowani uye kure anowedzera, zvichiita kuti zvisaite kushanda zvakazvimirira. Varwere veAlzheimer vanotanga kuve nekunetseka kwekutaura, mishonga uye kuona kwemeso kunowedzera. Muchirwere chepamusoro, murwere haakwanisi kuziva chero munhu, anotaura mazwi ega, dzimwe nguva haatauri zvachose. Kazhinji, anopedza nguva yose ari pamubhedha uye haakwanisi kudya ari oga. Kazhinji anova asina hanya zvikuru, asi pane dzimwe nguva pane zviratidzo zvechisimba chechisimba.
Kurapa kwechirwere cheAlzheimer
Mukurapa kwechiratidzo cheAlzheimer's, marudzi akasiyana emishonga anoshandiswa, anosanganisira: procognitive zvinodhaka (kuvandudza kugona kwekuziva), kuwedzera uropi metabolism, psychostimulating zvinodhaka, kuvandudza cerebral circulation, kudzikisa BP, anticoagulants, kudzivirira cerebral hypoxia, mavitamini, anti-inflammatory. zvinodhaka, psychotropic mishonga.
Sezvineiwo, hapana kurapwa kusati kwagadzirwa kwezvikonzero zvechirwere cheAlzheimer. Imwe yenzira dzakajairika dzekurapa ndeye kuwedzera kunaka kwe conductivity mucholinergic system - zvakanyanya kubatwa nechirwere ichi.
Kuwanikwa muna 1986 neuronal kukura factor (NGF) Zvakaunza tariro itsva yekubuda kwemushonga mutsva unoshanda muzvirwere zveurourodegenerative. NGF inoshandisa trophic (inovandudza kupona) uye triopic (inokurudzira kukura) migumisiro pane dzakawanda neuronal populations, inodzivirira kukanganisa kumasero emagetsi. Izvi zvakaratidza kuti NGF inogona kunge iri mukana wekugona kurapwa kwechirwere cheAlzheimer. Sezvineiwo, NGF ipuroteni isingayambuki ropa-brain barriers uye inofanirwa kupihwa intracerebrally. Nehurombo, jekiseni rakananga reNGF mumvura iri mucerebral ventricles rinokonzera zvakawanda zvakakomba mhedzisiro
Zvimwe zvidzidzo zvakare zvinoratidza izvozvo zvinhu kubva muboka re phosphodiesterase inhibitors inogona kuva mushonga unoshanda mukudzivisa kukura uye kuderedza zviratidzo zvechirwere cheAlzheimer. Boka revatsvakurudzi vepaColumbia University, rinotungamirirwa naOttavio Arancio naMichael Shelanski, vakawana kuti kurapwa nerolipram (mushonga unoshandiswa kurapa kuora mwoyo mune dzimwe nyika) kunovandudza chiyeuchidzo nekuziva. Uyezve, mushonga uyu unoshanda kwete chete mumatanho ekutanga echirwere, asiwo kune vanhu vane chirwere cheAlzheimer chepamusoro. Rolipram inonzi phosphodiesterase inhibitor. Phosphodiesterase inokonzeresa kuparara kwechiratidzo che molecule cAMP, iyo inomutsa kukura kwetsinga dzetsinga. Rolipram inodzivirira kuparara kwekampu nekudzivisa phosphodiesterase chiitiko, izvo zvinoita kuti cAMP iunganidze mune yakakuvadzwa tsinga. Nekuda kweizvozvo, maitiro anodiwa kuvandudza masero etsinga akakuvadzwa anogona kuitika.
Nekushandisa huropi zvakanyanya, tinohudzivirira kubva kune neurodegenerative maitiro uye panguva imwe chete kupinza neurogenesis, nekudaro tichirebesa hudiki hwepfungwa dzedu uye tichiwedzera mikana yekuramba tiine hungwaru kwehupenyu hwedu hwese. Saka kufunga kunoumba kwete hupenyu hwedu chete, asiwo hutano hwedu.
Verenga zvakawanda nezvekudya kwekudzivirira kweAlzheimer's!
Chinyorwa: Krzysztof Tokarski, MD, PhD, muongorori paInstitute of Pharmacology yePolish Academy of Sciences muKrakow
Nhengo A., Nhengo AC: Kurapwa mutsinga. Compendium. PZWL Medical Publishing, 2010
Gong BI, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O : Kuramba kuchivandudzika mu synaptic uye cognitive mabasa muAlzheimer mouse modhi mushure mekurapa rolipram. Clin Invest. 114, 1624-34, 2004
Kozubski W., Liberski PP: Neurology ”PZWL, 2006
Longstsaff A.: Hurukuro pfupi. Neurobiology. Polish Scientific Publishers PWN, Warsaw, 2009
Nalepa I: "Nezvezvakajairwa midzi yezvirwere neurodegenerative" Musangano "Brain Week", Krakow 11 - 17.03. 2002
Szczeklik A .: Zvirwere zvemukati. Inoshanda Mushonga, 2005
Vetulani J.: Maonero eAlzheimer's Disease Therapy. XX Winter Chikoro cheInstitute of Pharmacology yePolish Academy yeScience, 2003