THEammoniémiemuyedzo wekuyera mwero weammonia muropa.

Amoniya inobata basa mu pH kuchengetedza asi chinhu chine muchetura chinofanira kukurumidza kushandurwa nekubviswa. Kana iripo yakawandisa (hyperammoniémie), inonyanya kutyisa kuuropi uye inogona kukonzera kuvhiringidzika (chirwere chepfungwa), kuneta uye dzimwe nguva kunyange pakoma.

Yayo synthesis inoitika kunyanya muura, asiwo padanho renal uye tsandanyama. Kusvibiswa kwayo kunoitika muchiropa uko kunoshandurwa kuva urea, zvino inobviswa mune iyi fomu muweti.

Sezvo ichi chiri muchetura musanganiswa, zvakakosha kuita ammonia assay kana iwe uchifungidzira kuwedzera kwehuwandu hwayo.

Chiremba anogona kuraira dosage:

• kana achifungira a Hepatic kusakwana

• kuwana zvikonzero zvekusaziva kana kuchinja kwemaitiro

• kuziva zvikonzero zve coma (inozonyorwa pamwe chete nemimwe miedzo, yakadai seshuga yeropa, chiropa uye kuongorora kushanda kweitsvo, electrolytes)

• kutarisa kushanda kwekurapa kwehepatic encephalopathy (kuvhiringidzika kwechiitiko chepfungwa, neuromuscular function uye kuziva kunoitika semugumisiro wekusingaperi kana kuoma kwehepatic kukundikana)

Cherechedza kuti chiremba anogona kukumbira ammonia mucheche kana akagumbuka, kurutsa, kana kuratidza kuneta kwakanyanya mumazuva ekutanga ekuberekwa kwake. Iyi dosage inonyanya kuitwa kana munhu aiswa muchipatara.

Kutsunga kweammonia kunogona kuitwa nenzira dzakasiyana:

• by arterial blood sample, inoitwa mutsinga yemukadzi (mukutsemuka kwegodzi) kana tsinga yeradial (muchanza)

• nemuenzaniso weropa retsinga, rinowanzotorwa pagokora regokora, kunyanya padumbu risina chinhu

Yakajairika tsika dzeammonia muvakuru dziri pakati pe10 ne50 µmoles / L (micromoles parita) muropa re arterial.

Aya maitiro anosiyana zvichienderana nesample asiwo nerabhoritari iri kuita ongororo. Dzinodzikira zvishoma muropa retsinga pane muropa retsinga. Dzinogonawo kusiyana nebonde uye dzakakwirira muvana vachangozvarwa.

Kana zvigumisiro zvichiratidza kuwanda kweammonia (hyperammonemia), zvinoreva kuti muviri haukwanisi kuuputsa zvakakwana uye kuubvisa. Chiyero chepamusoro chinogona kubatanidzwa kunyanya ne:

• chiropa kutadza

• kukuvara kwechiropa kana itsvo

• hypokalemia (yakaderera potassium muropa)

• mwoyo kukanganisa

• kubuda ropa mudumbu

• chirwere chemajini chinokanganisa zvimwe zvikamu zveurea cycle

• kuomarara kwemhasuru
• chepfu (antiepileptic mushonga kana phalloid amanitis)

Kudya kwakaderera-protein (yakaderera munyama uye mapuroteni) uye mishonga (arginine, citrulline) inobatsira kubvisa ammonia inogona kurongerwa.