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Anti-Müllerian hormone: chii icho vese nulliparous vasikana vanofanira kuziva nezvazvo
Zviratidzo zvaro zvinonyatsoratidza hutano hwenhengo yekubereka. Kana iwe uchironga kubereka chete mushure memakore makumi matatu nemashanu, zvinongodiwa kuti uongororwe iyi hormone.
Anti-Müllerian hormone chiratidzo chakakosha kwazvo. Ichi chinhu chinotendera chiremba kuti aongorore mikana yekubereka yemukadzi uye shanduko dzinogona kuitika mukushanda kwemazai.
anotungamira gynecologist-reproductologist yenetiweki yenzvimbo dzekubereka uye genetics "Nova Clinic"
Iyo anti-Müllerian hormone - AMG - iripowo mumuviri wemurume. Mukuita kwekutanga kweiyo intrauterine kukura, ndiye iye anosarudza kukura kwemurume embryo. Mukukura, mumuviri wemurume, anti-Müllerian hormone inoramba ichivanzwa nemamwe masero mumatende, uye kuongororwa kwehuremu hwehomoni iyi kunobatsira pakuonekwa kwemhando dzakakomba dzekushaya murume.
Mumuviri wechikadzi, anti-Müllerian hormone yakavanzwa nemasero ari mune ovarian follicles. Huwandu hwemapundu hunosiyana muhupenyu hwese uye hushoma. Ichave yakanyanya padanho rekuvandudza intrauterine.
Nehurombo, kana iyo nhamba ye follicles yaderedzwa, haugone kumanikidza muviri kuti ubudise zvimwe. Kana zvekushandisa zvapera, kuenda kumwedzi kunouya. Ichi chiitiko chemuzvarirwo chekutsakatika kwebasa rekubereka, kana iko kushanda kwese kwechimiro uye mutinhimira wekuenda kumwedzi kusingaiti.
Pakutanga kwega kwega kwekuenda kumwedzi, imwe nhamba ye follicles inopinda mukukura kwakasimba muovary. Mudiki mukadzi, kunyanya kwavo kunogona kuve mune imwe kutenderera: pamakore makumi maviri nemashanu kusvika pamakumi maviri kusvika makumi maviri, pamakumi mana - 20-25 chete. Aya follicles, ayo akatotanga kukura, ari kunyatso kuoneka pane ultrasound. Zvinotaridzika semabhuru madiki 20-30 mamirimita muhukuru.
Aya follicles anosarudzwa kubva kune ovarian reserve. Iyo yekuchengetera ndiyo yakachengetedzwa yeese follicles. Uye iyo nzira yekusarudza inonzi kuunganidza. Zviri nyore kufungidzira izvi seakaundi keshi mubhangi rakavimbika, kubva pane imwe mari inobhadharwa mwedzi wega wega. Iyo yakadzikira huwandu hwemari paaccount, iyo yakaderera iyo mari iyo ichashandiswa mwedzi uno. Ndokusaka, nezera, iine kuderera kwechisikigo munzvimbo yekuchengetera ovari, huwandu hwemapollar anopinda mukukura mune yakapihwa kutenderera inoderera. Izvi zvinonyatso kuoneka pane ultrasound.
Iyo ramangwana reaya akasarudzwa follicles akafanotemerwa. Mumwe wavo anozove akakurisa, mukuita ovulation, zai rinoburitswa kubva pairi, kuti, sezvinobvira, ipe nhumbu. Vamwe vanozomira kusimukira, vachienda kune atresia (muchokwadi, kudzosera kumashure kuvandudza, kutsiva neanobatanidza matishu).
Nei AMG inonzi litmus test yehutano hwevakadzi
Iyo anti-Müllerian hormone yakavanzwa nemaseru eaya follicles ari akachengetedzwa. Sei zvichikosha? Sezvo iri iro mukana mukuru wechiratidzo ichi pamusoro pemamwe mahormone uye kuverenga huwandu hwenhengo pane iyo ultrasound scan.
Huwandu hwema follicles, sezviratidzo zveimwe mahormone, hunogona kusiyana kubva kutenderera kuenda kutenderera. Izvi zvinogona kunge zvichikonzerwa nehukuru hwehukuru hwe follicles, iyo nguva yekutenderera, pamberi pehomoni kurapwa. Asi iyo anti-Müllerian hormone icharamba yakagadzikana uye yakazvimirira. Icharatidza mamiriro echokwadi uye huwandu hwemapundu kwete eichi chakasarudzika, asi kune iyo ovarian reserve seyakazara. Ichi chiratidzo chakakodzera uye chakakosha. Kuderera kwenzvimbo dzekuchengetedza mazai kunoenderana nekudzikira kwema anti-Müllerian mahormone, uye iko kuderera kwezviratidzo izvi zvinonyanya kutinetsa.
Nguva yekutarisa padanho re AMH
nhodzera… Kana pamutsetse wechikadzi (amai, ambuya, hanzvadzi) paive nekukanganisa kwekuenda kumwedzi, kushaya mbereko, kutanga kuenda kumwedzi, zvino chingave chiratidzo chinotyisa uye chinoratidza kugarwa nhaka kwekuparara kwechimbichimbi kweiyo ovarian reserve.
Kuvhiya panhengo dzechiuno, kunyanya pamazai. Chikamu cheAMG chinobatsira kunzwisisa mamiriro enzvimbo yekuchengetera uye dzimwe nguva kuchinja matekiniki ekushanda. Mushure mekupindira chero kupi pane mazai, iyo sosi inoderera. Chikamu cheAMH chinobatsira kuona fungidziro uye zvirongwa zvekubereka.
Kukanganisa kwekuenda kumwedzi… Zvisingaenderani kana, pane kudaro, zvakajairwa, asi zvinoramba zvichipfupiswa kuenda kumwedzi zvakare chikonzero chekupa ropa re AMG. Zviratidzo zvekutanga zvisingaonekwe kuderera mudura zvakangoita sekuderera kwenguva yekutenderera (isingasviki mazuva makumi maviri nemaviri).
Kunonoka kuva amai… Vanotungamirirwa nehupenyu hwemagariro, vasikana vemazuvano vanoverengera kubata pamuviri kusvika vakura. Iyo yevakadzi yekubereka system inotanga kusangana nematambudziko ehupenyu nekubata mushure memakore makumi matatu nemashanu. Mune ino kesi, matambudziko mazhinji anogona kudzivirirwa nekuziva pamberi peiyo mamiriro eovarian chengetedzo. Dzimwe nguva zvine musoro kuti vitrify oocytes. Aya maitiro ekurapa ayo anotendera iwe kuchengetedza mazai ako nekupfuura kuderera kwechisikigo munzvimbo yekuchengetera ovarian isingamiswe. Chero matambudziko nekutora mimba kana kuronga kubata nhumbu mushure memakore makumi matatu nematatu zvinoratidza zvekuyera danho re AMH.
Maitiro ekugadzirira bvunzo ye AMG
Kuongororwa kweropa kune anti-Müllerian hormone kunogona kuitwa pane chero zuva rekuenda kumwedzi. Semutemo, AMG inopihwa pamwe nemamwe mahormone echikadzi, ayo anofanirwa kutariswa pakutanga kwekutenderera (pamazuva 2-5).
Usati watora AMG, zvinokurudzirwa kurega kuita zvakawandisa zvemuviri uye kuputa. Nenzira, kune ongororo dzakawanda dzinosimbisa mhedzisiro yakaipa yekusvuta paiyo nzvimbo yekuchengetedza ovari uye kudzikira kwemazinga eAMH.
Kune zvakare chimwe chinhu chinogona kuve nemhedzisiro pane kusunganidzwa kweanti-Müllerian hormone. Sekureva kwemimwe mishumo, muripo wekushomeka kwevhitamini D kunotungamira mukuwedzera kwemazinga eAMH. Izvo zvinokasira kutaura pakarepo kuti hazvibviri kuwedzera iyo chaiyo mamiriro eovarian dura, ndiko kuti, huwandu hwemapundu. Nehurombo, parizvino hapana nzira yekuita izvi, sezvo kugoverwa kwemazai mumazai mashoma.
Chii chinodzikira uye kuwedzera mumatanho e AMH zvinoratidza?
Zvakajairika mamiriro dura reovarian pamazera akasiyana rinotariswa paavhareji kuva kubva pa2 kusvika ku4 ng / ml.
Yakadzikira ovarian kuchengetedza iyo AMH nhanho ndeye 1,2 ng / ml. Kufungidzira kwekubereka pamwe nekuderera kweAMH isingasviki 0,5 ng / ml kunova kwakanyanya, uye mune mamwe mamiriro ezvinhu izvi zvinogona kuratidza kudikanwa kweIVF nemasero evanopa. Pano, kuwana panguva yakakodzera chiremba uye kuronga kwekubata kunokosha zvakanyanya.
Kune mamiriro ezvinhu apo AMH yakawedzerwa. Nhanho dzakakura kudarika 6,8 ng / ml dzinogona kuve dzakabatana ne polycystic ovary syndrome (PCOS) kana multifollicular ovary syndrome. Kuwedzera kwakakura kwe AMH pamusoro pe13 ng / ml kunoda kuwedzerwa kuongororwa uye kubviswa kwecology pathology, asi inowanzo kuwanikwa mune mamwe marudzi ePCOS.
Chero hazvo danho re AMH, chiremba chete ndiye anogona kupa ongororo izere yemamiriro acho. Kana iyo chiratidzo chakadzikiswa, kutanga pane zvese, iwe unofanirwa kutsvaga zano rehunyanzvi.