Mune vese varume nevakadzi, iyo luteinizing hormone kana LH inoita basa rakakosha mukuzvara. Zvechokwadi chikamu chehomoni dzinozivikanwa segonadotropins, conductors yezvipembenene zvekubereka. Kusagadzikana mukubuda kwayo nokudaro kunogona kuva chipingamupinyi pakubata pamuviri.

Luteinizing hormone kana LH (luteizing hormone) inoburitswa neanterior pituitary. Icho chikamu chegonadotropins: inodzora, pamwe chete nemamwe mahomoni, glands dzepabonde (gonads), munyaya iyi maovari muvakadzi uye testes muvarume.

Mune vakadzi

Pamwe chete nefollicle stimulating hormone (FSH), LH inoita basa rinokosha mukutenderera kweovarian. Ndizvo chaizvo kuvhiya kweLH kunokonzeresa ovulation panguva yekuteedzana kwekuita kweketani:

• iyo hypothalamus inoburitsa gnRH (gonadotrophin inoburitsa hormone) iyo inokurudzira pituitary gland;
• mukupindura, pituitary gland inobudisa FSH panguva yekutanga yekufamba (kubva pazuva rekutanga rekuenda kumwedzi kusvika kune ovulation);
• pasi pekuita kweFSH, mamwe maovarian follicles anotanga kukura. Iwo maovarian cell anowanikwa akatenderedza maturing ovarian follicles anobva abudisa more and more estrogen;
• kuwedzera uku muzinga reesrogen muropa rinoshanda pa hypothalamic-pituitary complex uye rinokonzera kusunungurwa kukuru kweLH;
• pasi pekuita kwekuvhiya uku kweLH, kushushikana mufollicle kunowedzera. Iyo inopedzisira yatyora uye inodzinga iyo oocyte muchubhu: iyi ndiyo ovulation, inoitika maawa makumi maviri nemana kusvika makumi matatu nematanhatu mushure mekuvhiya kweLH.

Mushure mokunge ovulation, LH inoramba ichiita basa rinokosha. Pasi pesimba rayo, kuputika kweovarian follicle inoshanduka kuita gland inodaidzwa kuti corpus luteum iyo inoburitsa estrogen neprogesterone, mahomoni maviri akakosha mukutanga kubata pamuviri.

Muvanhu

Kufanana nemaovari, ma testes ari pasi pekutonga kweFSH neLH. Iyo yekupedzisira inomutsa masero eLeydig ayo anokonzeresa kuburitswa kwe testosterone. Kubuda kweLH kunowanzoitika mushure mekuyaruka.

LH dosage inogona kurongerwa mumamiriro akasiyana:

Mune vakadzi

• pamberi pezviratidzo zvekuyaruka kana kunonoka;
• muchiitiko chekusagadzikana kwekuenda kumwedzi;
• kana uchinetseka kubata pamuviri: kuongororwa kwehomoni kunoitwa zvakarongeka sechikamu chekuongorora kushaya mbereko. Inosanganisira kunyanya kutsunga kweLH;
• kuona kuvhiya kweLH muweti kunoitawo kuti zvikwanise kuziva zuva rekuzvara, uye nekudaro kuona hwindo rake rekubereka kuitira kuti agone kugonesa mikana yake yekubata pamuviri. Iyi ndiyo musimboti we ovulation bvunzo dzinotengeswa muma pharmacy;
• kune rumwe rutivi, LH assay haina kufarira kuongororwa kwekuenda kumwedzi (HAS 2005) (1).

Muvanhu

• pamberi pezviratidzo zvekuyaruka kana kunonoka;
• kana uchinetseka kubata pamuviri: kuongororwa kwehomoni kunoitwawo zvakarongeka muvarume. Inosanganisira kunyanya iyo LH assay.

LH inoongororwa kubva pakuongorora ropa nyore. Muvakadzi, inoitwa pa2nd, 3rd kana 4th zuva rekutenderera mune referensi laboratori, panguva imwecheteyo seFSH uye estradiol assays. Muchiitiko che amenorrhea (kusavapo kwenguva), muenzaniso unogona kutorwa chero nguva.

Muchirevo chekuongororwa kwekunonoka kana kusimba kwekuyaruka mumusikana mudiki kana mukomana, iyo weti dosage inofarirwa. Iyo gonadotropins FSH neLH inovanzwa mufashoni panguva yekuyaruka uye inobviswa iri muweti. Urinary dosage saka inoita kuti zvikwanisike kuongorora zvirinani mazinga ekuvanzika pane punctual serum dosage.

Muvana

Huwandu hweFSH neLH hunogona kuve chiratidzo chekuyaruka kusati kwasvika.

Mune vakadzi

Schematically, yakakwira LH nhanho inotungamira kune yekutanga ovarian deficit (dambudziko nemaovha pachawo anokonzera gonadal insufficiency) izvo zvingave zvichikonzerwa ne:

• a congenital anomaly yemaovari;
• chromosomal abnormality (kunyanya Turner syndrome);
• kurapwa kana kuvhiyiwa kwakakanganisa ovarian basa (chemotherapy, radiotherapy);
• polycystic ovary syndrome (PCOS):
• thyroid chirwere kana adrenal chirwere;
• bundu reovarian.

Sezvineiwo, yakaderera LH nhanho inotungamira kune yechipiri ovarian kusagadzikana kweyakakwira mabviro (hypothalamus uye pituitary) zvichitungamira mukushaikwa mukukurudzira gonadal. Chimwe chezvikonzero zvinowanzoitika ndeye prolactin pituitary adenoma.

Muvanhu

Chiyero chepamusoro-soro cheLH chinotungamira kuongororwa kune chekutanga testicular kukundikana kunogona kuve nekuda kwe:

• chromosomal abnormality;
• kushayikwa kwekukura kwema testes (testicular agenesis);
• testicular trauma;
• chirwere;
• kurapwa (radiotherapy, chemotherapy);
• bundu re testicular;
• chirwere che autoimmune.

Iyo yakaderera LH mwero inodzokera kuhosha yekwakabva yakakwira, mupituitary uye hypothalamus (pituitary bundu semuenzaniso) zvichitungamira kune yechipiri testicular kukundikana.