Reye's Syndrome chirwere chisingawanzo kuputika chinogona kukonzera kukuvadza kwakakomba kuchiropa nehuropi. Kana chirwere chikasarapwa nekukurumidza, chinogona kukonzera kukuvara kwehuropi kusingagadzirike kana kutouraya munhu.

Nyaya dzinowanzobatwa neReye's syndrome vana uye vechidiki vaduku vari pasi pemakore 20. Zvisinei, zviitiko zvevakuru vakwegura zvakatoonekwa. (1)

Kuwanda kwechirwere ichi muFrance (nhamba yezviitiko zvechirwere panguva yakatarwa, muhuwandu hwevanhu) inokwana 0.08 kesi pavana zana.

Chikonzero uye chinongedzo chakaiswa pamberi muUnited States pakutora aspirin uye kukura kweReye's syndrome.

Uku kuwirirana kwakazoongororwa muFrance (pakati pe1995 ne1996). Iyo yekupedzisira yakabvumira kuverenga kwevana 8 vari pasi pemakore gumi nemashanu vane chirwere ichi uye kutora aspirin. Kubvunzurudzwa kweiyo bhenefiti / njodzi ratio yeAspirin haina zvakadaro haina kushanda kunyangwe yambiro. Izvi zvakanyanya kutarisisa kunyorerwa kwe aspirin zvine chekuita nevana vane zvirwere zvehutachiona, senge chickenpox, furuwenza, nezvimwe.

Nenzira iyi, iyo ANSM (National Agency for Health and Medicines) yakasimbisa chokwadi chekuti acetylsalicylic acid (aspirin) haifanirwe kupihwa kuvana vanotambura nerudzi urwu rwehutachiona kunze kwekunge mamwe ese matanho akundikana. . Mukuwedzera, muchiitiko chekurutsa, chirwere chetsinga, kuvhiringidzika kwekuziva kana maitiro asina kunaka, kurapwa uku kunofanira kurega. (3)

Zviratidzo zvinowanzobatanidzwa neReye's syndrome ndezvi: (1)

- kurutsa pasina chikonzero;

- indolence: kushaya kufarira, kufarira uye simba;

- kukotsira;

- kuwedzera kufema;

– pfari.

Izvi "zvizhinji" zviratidzo zvinowanzoonekwa mazuva mashoma mushure mehutachiona hwehutachiona.

Mune zvimwe zviitiko, izvi zviratidzo zvekutanga zvinogona kufambira mberi kusvika kune zvakanyanya kuoma: (1)

- kukanganisa kwehunhu: kushatirwa, kushushikana, hunhu hwehasha, nezvimwe;

- mamiriro ekuvhiringidzika uye kunetseka izvo dzimwe nguva zvinogona kubatanidzwa nekufungidzira;

– kurasikirwa nepfungwa izvo zvinogona kukonzera kukoira.

Kubvunzurudza kwachiremba kunofanira kunge kuri kwekutanga dice kufungidzira kwechirwere ichi mumwana.

Kunyangwe aya marudzi ezviratidzo asina kunyanyobatanidzwa neReye's syndrome, zvinodikanwa kuti utarise iyo hypothesis kuitira kusimbisa kana kwete kukura kweiyo pathology. Muchiitiko ichi, zvakakosha kunyevera chiremba nezvekugona kudyiwa kweAspirin muhuduku iyo inogona kunge yakabatana nekukura kwechirwere ichi. Uyezve, kana mwana asati atora mishonga yekutora aspirin kare, mukana wekukura kwechirwere unogona kubviswa. (1)

Mabviro chaiwo eReye's syndrome parizvino haazivikanwe. Nekudaro, zviitiko zvakawanda zvechirwere zvinobata vana nevakuru vechidiki (vari pasi pemakore makumi maviri) kupora kubva kuhutachiona hwehutachiona, uye kunyanya furuwenza kana huku. Pamusoro pezvo, varwere ava vaive nemishonga yeaspirin mukurapwa kwehutachiona uhu. Mupfungwa iyi, kurapwa neAspirin yevirosis kunoita kuti ive chikonzero chinowanzo kuwanikwa.

 Chimwe chinhu chekuwedzera mukuvandudzwa kwechirwere ichi chinoguma mune zvimiro zviduku mukati memasero: mitochondria, iyo yakakuvadzwa.

Aya ma cellular maumbirwo anopa simba rinodiwa pakukura kwesero. Izvo zvinonyanya kukosha pakushanda kwakakodzera kwechiropa. Chokwadi, mitochondria inosefa chepfu kubva muropa uye inobatanidzwawo mukugadzirisa shuga yeropa (mazinga eshuga) mumuviri.

Mumamiriro ezvinhu apo aya maitiro ekugadzirisa hepatic anokanganisa, chiropa chinogona kuparadzwa. Kuparara kwechiropa kunobva mukugadzirwa kwemakemikari ane chepfu. Nekupfuura nemuropa, chepfu iyi inogona kukuvadza chipenyu chose uye kunyanya uropi. (1)

Zvimwe zvirwere zvinogonawo kuva chikonzero chezviratidzo zvine chokuita neReye's syndrome. Mupfungwa iyi, kuongororwa kwerudzi urwu rwechirwere kunogona kubviswa mune mamwe mamiriro ezvinhu. Aya mamwe ma pathologies anosanganisira:

- meningitis: kuzvimba kwezvidziviriro membranes zvinofukidza uropi uye musana;

- encephalitis: kuzvimba uropi;

- Zvirwere zvinounganidza pamwe chete kusagadzikana kwemetabolism inokanganisa maitiro emakemikari echipenyu. Iyo inonyanya kuzivikanwa ndeye: acyl-CoA yepakati cheni dehydrogenase (MCDD).

Dambudziko guru reReye's syndrome rinonyanya kutora aspirin paunenge uchirapa chirwere chetachiona chefuruwenza kana chickenpox muvana kana vechidiki.

Kuongororwa kwechirwere ichi kunotanga nekusiyana-siyana kwekuona zviratidzo zvinoratidzwa nemurwere pamwe nenhoroondo yake, kunyanya maererano nekutora aspirin panguva yekurapa kwehutachiona hwehutachiona.

Ropa uye weti kuongororwa kunogona zvakare kubvumidza kuongororwa kweReye's syndrome mupfungwa yekuti muchetura weiyo pathology unogona kuwanikwa mumvura idzi dzemuviri. Kuvapo kwezvinhu izvi zvinokuvadza kumuviri ndiko kunobva kune kusashanda zvakanaka kwechiropa.

Mimwe miedzo inogona zvakare kuve iyo yekuratidzira kweiyo syndrome:

- iyo scanner, zvichiita kuti zvikwanise kuratidza chero kuzvimba muuropi;

- a lumbar puncture, panguva iyo sampuli ye cerebrospinal fluid inotorwa kubva mumutsipa wepelinha uye kuongororwa kuitira kuti ione kuti inogona kuvapo kwebhakitiriya kana mavairasi;

- biopsy yechiropa, umo sampuli yechiropa chechiropa inotorwa uye inoongororwa pasi pe microscope kuti ione kuvapo kana kusavapo kwemasero ane chokuita neReye's syndrome.

Kurapa kwechirwere kunofanira kuitwa nokukurumidza kana chirwere chacho chaitwa.

Chinangwa chekurapa ndechekuderedza zviratidzo uye kubvumira nhengo dzinokosha kuti dziite mabasa adzo pamwe nekudzivirira uropi kubva pakukuvadzwa kunogona kukonzerwa nechirwere.

Nhamba huru yemishonga inogona kupihwa, kazhinji intravenously, senge:

- electrolytes uye mvura, zvichiita kuti zvikwanise kudzorera kuenzana kwemunyu, zvicherwa uye zvinovaka muviri mumuviri (kunyanya glycemia muropa);

- diuretics: kubatsira chiropa mukushanda kwayo;

- ammonia detoxifiers;

- anticonvulsants, mukurapa kwepfari pfari.

Rubatsiro rwekufema runogonawo kurongerwa mumamiriro ezvinhu apo mwana ane dambudziko mukufema kwake.

Kana kuzvimba muuropi kwangopera, mamwe mabasa anokosha emuviri anowanzodzokera kune zvaari. (1)