Pamusoro peiyo 2009 furuwenza A (H1N1) strain maantigens, jekiseni rinosanganisira adjuvant uye inochengetedza.

Mushonga uyu unonzi AS03 uye wakagadzirwa nekambani yeGSK, sechikamu chekugadzirwa kwejekiseni rekudzivirira utachiona hwefuruwenza H5N1. Iyi "mafuta mumvura" adjuvant inoumbwa ne:

• tocopherol (vitamin E), vhitamini inokosha pakushanda zvakanaka kwemuviri;
• squalene, lipid inogadzirwa yakasikwa mumuviri. Iyo yakakosha yepakati mukugadzirwa kwecholesterol uye vhitamini D.
• polysorbate 80, chigadzirwa chiripo mumajekiseni mazhinji nemishonga kuitira kuchengetedza homogeneity.

Iyo adjuvant inoita kuti zvikwanise kuwana mari yakawanda yekuchengetedza muhuwandu hweantigen inoshandiswa, iyo inofambisa kubayiwa kwenhamba yakawanda yevanhu nekukurumidza sezvinobvira. Iko kushandiswa kweiyo adjuvant kunogona zvakare kupa muchinjika-dziviriro kubva mukushandurwa kwehutachiona antigen.

Adjuvants haisi itsva. Vave vachishandiswa kwemakumi emakore akati wandei kumutsa mhinduro yekudzivirira kwemuviri kune vaccine, asi kushandiswa kweadjuvants nefuruwenza vaccin hakuna kumbobvumidzwa muCanada. Saka iyi ndiyo yekutanga munyaya iyi.

Mushonga uyu une zvakare mecury-based preservative inonzi thimerosal (kana kuti thiomersal), inoshandiswa kudzivirira kusvibiswa kwejekiseni nemishonga inotapukira kubva mukukura kwebhakitiriya. Mushonga unozivikanwa wefuruwenza mwaka nemwaka mizhinji yekudzivirira hepatitis B ine iyi stabilizer.

Iko hakuna data yakavimbika pamusoro pekuchengetedzwa kweiyo adjuvanted vaccine muvakadzi vane pamuviri uye vana vadiki (6 mwedzi kusvika 2 makore). Zvakadaro, World Health Organisation (WHO) inoona kuti kutungamira kwejekiseni iri kuri nani pane kusavapo kwejekiseni, sezvo mapoka maviri aya ari kunyanya kutarisana nematambudziko kana abatwa.

Zviremera zveQuebec zvakasarudza kupa vakadzi vane pamuviri vaccine pasina adjuvant, senzira yekuzvidzivirira. Huwandu hudiki hwemajekiseni ejekiseni asina kuvharwa aripo parizvino haaite, zvisinei, kuti zvikwanise kupa sarudzo iyi kune vese vanaamai vemangwana. Naizvozvo hazvina kufanira kuzvikumbira, kunyange kuvana vaduku. Sekureva kwenyanzvi dzeCanada, dzinotaura nezvekutanga kuyedzwa kwekiriniki, hapana chikonzero chekutenda kuti iyo adjuvant vaccine inokonzeresa chero mhedzisiro - kunze kwengozi yakanyanya yefivha - muvana vane mwedzi mitanhatu kusvika kumakore matatu.

Mushonga usina adjuvant, uyo unowanzo kurudzirwa kuvakadzi vane pamuviri, une thimerosal yakapetwa ka10 pane yekudzivirira yeadjuvant, asi maererano neruzivo rwesaenzi rwemazuva ano, hapana humbowo hwekuti vakadzi vakagamuchira iyi vaccine vakave neadjuvant vaccine. kupfupfudzika kana kuzvara mwana akaremara. Iye Dr de Wals, weINSPQ, anonongedza kuti "jekiseni risina adjuvant richine chete 50 µg yethimerosal, inopa mecury shoma pane inogona kudyiwa panguva yekudya kwehove".

Mhedzisiro ine chekuita nejekiseni yefuruwenza kazhinji inoshamisira uye inogumira kumarwadzo akapfava apo tsono yakapinda muganda reruoko, fivha yakapfava, kana kurwadziwa zvishoma mukati mezuva rose kana zvakadaro. mazuva maviri mushure mekudzivirira. Kutungamirirwa kweacetaminophen (paracetamol) kuchabatsira kuderedza zviratidzo izvi.

Muzviitiko zvisingawanzoitiki, munhu anogona kunge aine maziso akatsvuka kana kuvava, kukosora, uye kuzvimba zvishoma kumeso mukati memaawa mashoma awana jekiseni. Kazhinji mhedzisiro iyi inopera mushure memaawa makumi mana nemasere.

Padenda rekudzivirira chirwere cheA (H1N1) 2009, miedzo yekiriniki iri kuitika muCanada haisati yapera panotanga chirongwa chekubaya nhomba, asi vakuru vehutano vanotenda kuti njodzi yekukanganisa ishoma. Sekureva kweWorld Health Organisation, pari zvino nyaya shoma dzemhedzisiro dzakaonekwa munyika umo jekiseni rakatopihwa pamwero mukuru. MuChina, semuenzaniso, 4 pavanhu makumi matatu nevapfumbamwe vakabayiwa vangadai vakawana mhedzisiro yakadaro.

Vanhu vanenge vatova nezai rakanyanya allergy (anaphylactic shock) vanofanira kuona chiremba weallergist kana mhuri yavo vasati vabaiwa.

Penicillin allergy haisi contraindication. Zvakadaro, vanhu vakamboita anaphylactic reactions kune neomycin kana polymyxin B sulfate (mishonga inorwisa mabhakitiriya) munguva yakapfuura havafanirwe kuwana iyo unadjuvanted vaccine (Panvax), nekuti inogona kunge iine zvisaririra zvayo.

Thimerosal (vaccine preservative) zvechokwadi inobva kune mercury. Kusiyana nemethylmercury - iyo inowanikwa munharaunda uye inogona kukonzera uropi hwakanyanya uye kukuvara kwetsinga, kana ikadyiwa muhuwandu hwakawanda - thimerosal inogadziriswa muchigadzirwa chinonzi ethylmercury, iyo inokurumidza kucheneswa nemuviri. . Nyanzvi dzinofunga kuti kushandiswa kwayo kwakachengeteka uye hakuiti ngozi kune hutano. Zvikumbiro zvekuti mercury mumajekiseni inogona kuve yakabatana ne autism inopokana nemhedzisiro yezvidzidzo zvakati wandei.

Mushonga wekudzivirira denda wakagadzirwa uchishandisa nzira dzakafanana nedzese nhomba dzefuruwenza dzakatenderwa uye kupihwa mumakore achangopfuura. Misiyano chete ndeye kuvapo kweadjuvant, iyo yaive yakakosha kuburitsa huwandu hwakadaro hwedosi pamutengo unogamuchirwa. Mubatsiri uyu haasi mutsva. Yakave ichishandiswa kwemakore kumutsa mhinduro yekudzivirira kwemuviri kune vaccine, asi kuwedzera kwayo kune vaccine yefuruwenza yakanga isati yambobvumidzwa muCanada. Zvakaitwa kubva muna Gumiguru 21. Health Canada inovimbisa kuti haina kupfupisa nzira yekubvumidza.

Kana iwe wakambobatwa ne2009 strain yehutachiona hweA (H1N1), une kudzivirirwa kwakafanana kune iyo inofanirwa kupihwa nejekiseni. Nzira chete yekuve nechokwadi chekuti imhando iyi yehutachiona hwefuruwenza yawabata ndeyekuongororwa nachiremba kuti zvidaro. Nekudaro, kubva pakasimbiswa kuti furuu iyi yaive denda, WHO yakakurudzira kusaona zvine hungwaru 2009 rudzi rweA (H1N1). Nekuda kweizvi, ruzhinji rwevanhu vane furuwenza havazivi kuti vakabatwa nehutachiona hweA (H1N1) kana humwe hutachiona hwefuruwenza. Vakuru vezvokurapa vanotenda kuti hapana njodzi mukugamuchira jekiseni, kunyangwe munhu akatotapukirwa nehutachiona hwedenda.

Tichifunga nezve kuwanda kwefuruwenza A (H1N1) mumwedzi ichangopfuura, jekiseni kurwisa furuwenza mwaka, yakarongerwa kudonha kwa2009, yakamisikidzwa kuna Ndira 2010, mubazi rakazvimirira uye munharaunda yeruzhinji. Kumisikidzwa uku kune chinangwa chekuisa pamberi pemushandirapamwe wekudzivirira furuwenza A (H1N1), uye kunobvumira vakuru vehutano kuti vagadzirise zano ravo rekurwisa furuwenza yemwaka kuti vatarise mune ramangwana.

MuCanada, vanhu vari pakati pe4 ne000 vanofa nefuruwenza yemwaka wega wega. MuQuebec, kune vangangoita 8 vanofa pagore. Zvinofungidzirwa kuti 000% yevanhu vanobatwa nefuruwenza yemwaka vanofa nayo.

Parizvino, nyanzvi dzinofungidzira kuti hutachiwana hwehutachiona hweA (H1N1) hwakafanana nehwefuruwenza yemwaka, kureva kuti huwandu hwerufu hunokonzerwa nahwo hunosvika 0,1%.

Mishonga yenguruve yefuruwenza yakashandiswa muUnited States muna 1976 yakabatana neyakaderedzwa (inenge 1 kesi pa100 vaccinations), asi njodzi huru yekuva neGuillain-Barré syndrome (GBS - neurological disorder, pamwe ye 'autoimmune origin) mukati memavhiki 000 kubva. administration. Majekiseni aya akange asina adjuvant. Zvikonzero zvemubatanidzwa uyu hazvisati zvazivikanwa. Zvidzidzo zvemamwe majekiseni efuruwenza akapihwa kubvira 8 haana kuratidza kudyidzana neGBS kana, muzviitiko zvisingawanzo, njodzi yakaderera ye1976 kesi pamiriyoni imwe chete yekudzivirira. Zviremera zvekurapa zveQuebec zvinotenda kuti njodzi haina kukwira kune vana vasina kumbobvira vabaiwa.

The Dr de Wals anotaura kuti chirwere ichi hachiwanzoitiki muvana. “Zvinonyanya kubata vanhu vakura. Sekuziva kwangu, hapana chikonzero chekutenda kuti vana vasina kumbobaiwa vari panjodzi huru kupfuura vamwe. “

Pierre Lefrançois - PasseportSanté.net

Zvinyorwa: Quebec Ministry of Health and Social Services uye National Institute of Public Health yeQuebec (INSPQ).