Acromegaly chirwere chinokonzerwa nekuwanda kwekukura kwehomoni (inonziwo somatotropic hormone kana GH yeGrowth Hormon). Izvi zvinotungamirira kukuchinja kwechimiro chechiso, kuwedzera kwehukuru hwemaoko nemakumbo uyewo nhengo dzakawanda, iyo inokonzera zviratidzo zvikuru uye zviratidzo zvechirwere.

Icho chiitiko chisingawanzoitiki, chinokanganisa mazana matanhatu kusvika makumi manomwe emakesi pamiriyoni yevagari, inomiririra 60 kusvika ku70 kesi pamiriyoni yevagari pagore.

Muvanhu vakuru, inowanzoonekwa pakati pemakore e30 ne40. Kusati kwasvika, kuwedzera kweGH kunokonzera gigantism kana giganto-acromegaly.

Chikonzero chikuru cheacromegaly ndeye benign (isina kenza) bundu repituitary gland, gland (inonziwo pituitary gland), iri muuropi uye iyo inowanzobudisa mahomoni akawanda anosanganisira GH.