Basa reADH hormone ndeyekutarisa kurasikirwa kwemvura neitsvo, saka zvakakosha pakushanda kwayo kwakakodzera. Zvinosuruvarisa, kubudiswa kwehomoni iyi nguva nenguva hakuitike zvakanaka. Ndezvipi zvikonzero? Kunyanya kukwira kana kuderera kwehomoni iyi kungave nemhedzisiro here?

Iyo antidiuretic hormone inonziwo vasopressin, dzimwe nguva inodaidzwa zvakare nepfupiso AVP yeArginine-vasopressin, ihomoni inogadzirwa neneurons ye hypothalamus. Nekubvumidza kudzoreredzwa kwemvura nemuviri, iyo hormone ADH inoshandisa chiito chayo muitsvo.

Pangove yakavanzwa ne hypothalamus, ichachengetwa mupituitary gland isati yasunungurwa kana ichinge yapera mvura. Iyo hypothalamus nepituitary zviri pazasi peuropi.

Basa reADH nderekutarisa kurasikirwa kwemvura kubva muitsvo (diuresis) kuti ive nechokwadi chekuti sodium muropa inoramba iri pamwero wakajairika. Kana mazinga e sodium achikwira, ADH inovanzwa kuderedza kurasikirwa kwemvura kubva muitsvo, zvichiita kuti weti isvibe.

Chiyero chayo chinotarisirwa kuona uye kusiyanisa nephrogenic chirwere cheshuga insipidus kubva pakati pechirwere cheshuga insipidus kana kuvapo kwechirwere chisina kufanira secretion syndrome.

Low antidiuretic hormone mazinga anogona kubatanidzwa ne:

• Chirwere cheshuga insipidus : itsvo inotadza kuchengetedza mvura uye vanhu vanobva vaburitsa weti yakawanda uye yakanyungudutswa (polyuria) yavanofanira kuripa nekunwa mvura yakawanda (polydipsia). Kune marudzi maviri echirwere cheshuga insipidus, central diabetes insipidus (CDI), iyo yakawanda uye inokonzerwa nekushaya kweADH, uye nephrogenic diabetes insipidus, hormone iripo asi haishande.

Yakakwira antidiuretic hormone mazinga anogona kubatanidzwa ne:

• EHE : Syndrome yeasina kufanira secretion ye antidiuretic hormone inotsanangurwa ne hyponatremia inokonzerwa nekuwedzera kwemvura muropa ine yakaderera sodium level. Kazhinji ye hypothalamic (bundu, kuzvimba), tumoral (kenza yemapapu) mavambo. Zviratidzo zve hyponatremia ndezvekunyunyuta, kurutsa, kuvhiringidzika;
• Zvironda zvehurongwa hwemitsipa: hutachiona, kukuvara, kubuda ropa, mamota;
• meningoencephalitis kana polyradiculoneuritis;
• A craniocerebral trauma;
• Epilepsy kana acute psychotic seizures.

Munguva yesampuli yeropa, anti-diuretic hormone inoyerwa. Zvadaro, muenzaniso unoiswa mu centrifuge pa 4 ° uye pakupedzisira pakarepo wakaoma nechando pa -20 °.

Kuve uri mudumbu usina chinhu hakubatsiri pakuongorora uku.

Pasina kudziviswa kwemvura, yakajairika kukosha kweiyi hormone inofanira kunge iri pasi pe4,8 pmol / l. Nekurambidzwa kwemvura, tsika dzakajairika.

Zvichienderana ne-pathologies, kune nzira dzakasiyana dzekurapa:

Kurapa kwechirwere cheshuga insipidus

Kurapa kunoitwa maererano nechikonzero chakaonekwa, uye kunofanirwa kurapwa kana paine. Chero zvazvingava, haufaniri kurega munhu wacho asisina mvura kana kuti akawandisa uye edza kuenzanisa nekudya kwemunyu kwakaderera.

• Muchiitiko chepakati chirwere cheshuga insipidus, kurapwa kunobva pakudya kwehomoni inofananidzira kune antidiuretic hormone, desmopressin, iyo antidiuretic chiito chine simba. Kutungamira kunowanzo endonasal kamwe kana kaviri pazuva. Kuchengetedza kunofanira kutorwa kuti usapfuure muyero wakatarwa nachiremba wako nekuti kuwandisa kunogona kutungamirira kukuchengetedza mvura uye dzimwe nguva kuzununguka;
• Munyaya yenephrogenic diabetes insipidus, iyi hormonal treatment haishande. Chirwere cheitsvo chakabatanidzwa naizvozvo chichada kurapwa.

Kurapa kweSyndrome yeIsina Kufanira Antidiuretic Hormone Secretion:

Kudzora kunwa mvura uye kurapwa kwechikonzero kana zvichibvira. Vanhu vane SIADH vanoda kurapwa kwe hyponatremia kwenguva yakareba.

Zvinwiwa zvinoiswa mutsinga, kunyanya zvinwiwa zvine sodium yakawandisa (hypertonic saline), dzimwe nguva inopihwa. Mishonga iyi inofanirwa kupihwa nekuchenjerera kudzivirira kukurumidza kukwira kweserum sodium (sodium concentration muropa).

Kana serum yeropa ikaramba ichidonha kana kusasimuka kunyangwe ichidzikamisa kunwa mvura, vanachiremba vanogona kuraira mishonga inoderedza mhedzisiro yevasopressin paitsvo, kana zvinodhaka zvinovhara vasopressin receptors uye kudzivirira itsvo. inopindura vasopressin.