Inonziwo fetuin, iyoalpha-fetoprotein ndiwo protein zvakasikwa na yolk bag uye chiropa du fetus mubudiriro. Inowanikwa muropa re fetal uye raamai (panguva yekuzvitakura). Muvana vachangozvarwa, mwero wayo unodzikira mavhiki mashoma mushure mekuzvarwa.

Muvanhu vakuru, alpha-fetoprotein inogona kuoneka zvakare panguva yezvimwe zvirwere, nguva zhinji hepatic kana bundu.

Alpha-fetoprotein kuongororwa inogona kurongerwa kumukadzi panguva yekuzvitakura kana kune vanhu vakuru kunze kwekuzvitakura.

panguva pamuviri, alpha-fetoprotein analysis inoshandiswa pakuongororwa kwepamuviri yezvakasiyana zvakasiyana-siyana uye inoitwa muchipiri chetatu. Muedzo unowanzo kuve wakarurama pakati pevhiki dzegumi nematanhatu negumi nemasere. Kuongororwa kwealpha-fetoprotein kunoitika panguva imwe chete neyechorionic gonadotropic hormone (HCG), estriol uye inhibin A, mahomoni epa placental. Chinangwa chiri kunyanya kuona kukanganisa kweneural chubhu (inozova tsinga) yefetus, seSpina bifida, asiwo chromosomal abnormalities, senjodzi ye trisomy 16 (kana Down's syndrome).

Muvakuru (kunze kwepamuviri), kuongororwa kwealpha-fetoprotein kunogona kuitwa kuongorora matambudziko echiropa kana kuona mamwe magomarara.

Kuongororwa kwealpha-fetoprotein kunosanganisira a kuongorora ropa pamwero wetsinga uye haidi chero gadziriro chaiyo. Chiremba anoisa tourniquet paruoko rwemurwere rwemberi, zvingangoita masendimita gumi pamusoro penzvimbo ichaitwa venipuncture, kazhinji pamawere egokora.

Mumadzimai ane pamuviri, chikamu che alpha-fetoprotein inogadzirwa ne fetus inopinda muropa reamai, uye naizvozvo hapana amniotic kana fetal sampling inodiwa. Muenzaniso weropa unotorwa nenzira ye "classic".

Muvanhu vakuru, varume nevakadzi kunze kwenguva yekuzvitakura, huwandu hwealpha-fetoprotein huri pasi pe10 ng / ml yeropa.

Kuwedzera kwehuwandu hwealpha-fetoprotein muropa kunogona kuratidza:

• chirwere chechiropa, zvakadai cirrhosis, ye gomarara rechiropa, ivo chidhakwa hepatitis kana kuti hutachiona hepatitis

• un kenza machende, mazai, dumbu, chirwatata kana bile ducts.

Muvakadzi vane pamuviri, mune yechipiri trimester, iyo alpha-fetoprotein level inowanzova pakati pe10 ne200 ng / ml. Yakakwira alpha-fetoprotein mazinga anogona kukonzera:

• a neural tube defect mumwana ari kukura: Spina bifida, anencephaly

• kukanganisa kwetsinga

• hydroencephaly

• kukanganisa kwegurokuro kana itsvo

Ukuwo, mwero wakaderera unogona kuva chiratidzo chechromosomal abnormality senge Down syndrome (trisomy 21).

Chenjerera, zvisinei, iyo alpha-fetoprotein level inosiyana panguva yekuzvitakura. Saka zvakakosha kunyatsoziva nhanho yekuzvitakura iyo mukadzi ari panguva yekuedzwa. Zvisizvo zvealpha-fetoprotein mhedzisiro inogona zvakare kuve nekuda kwekuzvitakura kwakawanda kana kufa kwe fetus.

Miedzo yakawedzerwa naizvozvo inodiwa kana pakaitika mazinga e<em>alpha-fetoprotein asina kujairika, akadai se<em>ultrasound kana kuti amniocentesis (kubviswa kwe<em>amniotic fluid yakapoteredza chibereko).