Ichokwadi chokuti munguva pfupi iri kutevera oncology pakupedzisira icharega kuva mutsara, masayendisiti zvakare akatanga kutaura. Uyezve, zvichangobva kuwanikwa nevatsvakurudzi veYunivhesiti yeNotre Dame (South Bend, United States) zvinoratidza kuti kubudirira kwechokwadi kunobvira kunyange mukurapa marudzi ane ngozi zvikuru ekenza, ayo akaoma zvikuru pakurapa kuripo.
Kuburitswa kwenhau kwakatumirwa paMedical Xpress webhusaiti inotaura nezve chaiwo zvimiro zveRIPK1 protein enzyme. Ndiye mumwe wevatori vechikamu mukuita kwe cell necrosis. Zvisinei, sezvakaonekwa nemasayendisiti, puroteni iyi inogonawo kuvharidzira kukura kweakaipa neoplasms uye kuitika kwemasastases. Nekuda kweizvozvo, komisheni iyi inogona kuve chimwe chezvikamu zvemishonga zvakagadzirirwa kurapwa kwemhando dzine njodzi dzegomarara.
Sezvo yakazozivikanwa semhedzisiro yechidzidzo, RIPK1 inobatsira kuderedza kuvapo kwemitochondria mumasero. Aya ndiwo organelles ane basa rekushandiswa kwesimba rekuchinjana. Kana nhamba yavo ichiderera, iyo inonzi "oxidative stress" inotanga kukura. Huwandu hukuru hwemhando yeokisijeni inoshanda inokuvadza mapuroteni, DNA uye lipids, semhedzisiro iyo maitiro ekuzviparadza ega anotanga. Mune mamwe mazwi, maitiro ekuti necrosis kana cell apoptosis anotanga.
Masayendisiti anoyeuchidza kuti necrosis inzira yehutano umo sero pachayo rinoparadzwa, uye kusunungurwa kwezviri mukati kunoitika munzvimbo ye intercellular. Kana sero ikafa maererano nechirongwa chayo chemajini, icho chinonzi apoptosis, ipapo masara aro anobviswa kubva munyama, izvo zvinobvisa mukana wekuzvimba.
Sekureva kwevaongorori veAmerica, RIPK1 inogona kuve imwe yezvinokonzeresa kune inonzi "inodzorwa sero kufa" maitiro. Mune mamwe mazwi, inogona kushandiswa sechombo che "point kuparadza" - kushandisa zvakanangwa "kurova" kune bundu neprotein enzyme. Izvi zvichabatsira kumisa nzira ye metastasis uye kuwedzera kweoplasm.