Izwi rekuti "collagenosis" rinobatanidza seti yezvirwere zve autoimmune zvinoratidzwa nekuzvimba uye kukuvadzwa kweimmunological kune inobatana tishu, hyperactivity ye immune system, hukuru hwevakadzi, kushamwaridzana neantinuclear antibodies uye kupararira kwemaronda. Iyo inobatanidza tishu iripo mumuviri wese, nhengo dzese dzinofanirwa kukanganiswa neimwe nzira kana kushoma yakabatana, nekudaro kusiyana kukuru kwezviratidzo zvinogona kubva kucollagenosis. Chinangwa chekutungamira kwavo ndechekudzora chiitiko chechirwere uye kuchidzikisa kusvika padanho rakaderera.

Collagenoses, inonziwo connectivitis kana systemic zvirwere, inoungana pamwe chete seti yezvisingaperi zvisingaperi zve autoimmune kuzvimba zvirwere, zvichibva mukuumbwa kwe collagen mumatishu akapfuma mukati me intercellular matrix, anoti anobatana tishu.

Collagen ndiyo protein yakawanda kwazvo mumuviri wedu. Inobvumira nhengo dzedu nemuviri wedu kuti zvigadzikane pasina kuomeswa zvakanyanya, nepo ichichinjika zvakakwana. Yakavanzika neanobatanidza matishu maseru, collagen inodyidzana nehuwandu hukuru hwemamwe mamorekuru kuti aumbe mafiber uye abudise matishu ane fibrous ane anotsigira uye anotambanuka-resistant zvimiro.

Inonyanya kuvakadzi, collagenases inokwanisa kusvika kune nhengo dzose (digestive system, mhasuru, majoini, mwoyo, nervous system). Ichi ndicho chikonzero kuratidzwa kwayo kwakawanda sehuwandu hwenhengo dzakabatwa. Hunhu hwehupenyu dzimwe nguva hunokanganiswa zvakanyanya. Mhedzisiro yezvirwere izvi inotsamira zvakanyanya pakukuvadzwa kwenhengo dzinokosha.

Iyo inonyanya kuzivikanwa collagenosis ndeye systemic lupus erythematosus (SLE). Collagenosis inosanganisira zvirwere zvinotevera:

• rheumatoid arthritis;
• oculourethro-synovial syndrome (OUS);
• spondyloarthropathies (kunyanya ankylosing spondylitis);
• Horton chirwere;
• Wegener's granulomatose;
• rhizomelic pseudo-polyarthritis;
• scleroderma;
• yakasanganiswa systemic chirwere kana Sharp syndrome;
• microangiopathie thrombotique;
• periarteritis nodosa;
• chirwere cheGougerot-Sjögren;
• dermatomyositis;
• dermatopolymyositis;
• the maladie de Behçet;
• sarcoïdose;
• histiocytosis;
• Still's maladie;
• periodic chirwere;
• kuwandisa zvirwere uye zvimwe zvirwere zve metabolic;
• chirwere chisingaperi chechiropa;
• zvirwere zve elastic tissue;
• congenital kana akawana zvirwere zve serum complement;
• scleroderma;
• Chirwere cheChurg-Strauss;
• systemic vasculitis, nezvimwewo.

Havasati vazivikanwa. Panogona kunge paine kusagadzikana kweiyo immune system, sezvinoratidzwa muropa revarwere, kuvepo kweajairika masoja ekudzivirira chirwere, anonzi autoantibodies kana antinuclear antibodies, anonangidzirwa kune iwo ega zvikamu zvemasero emuviri. Mamwe maantigen e histocompatibility system (HLA) anowanikwa zviri nyore panguva yezvimwe zvirwere, kana mune dzimwe mhuri dzinowanzo batwa, izvo zvinoratidza kusimudzira basa reiyo genetic factor.

Iyo inobatanidza tishu iripo mumuviri wese, nhengo dzese dzinogona kukanganiswa nenzira yakawedzera kana kushoma yakabatana, nekudaro zvakasiyana-siyana zvezviratidzo zvinogona kukonzerwa nekurwiswa:

• articulate;
• cutaneous;
• cardiac;
• pulmonary;
• hepatic;
• renal;
• nechepakati kana peripheral nerve;
• vascular;
• kugaya.

Iko kushanduka kwe collagenosis kunowanzo tora maitiro ekudzokerazve kunowanzobatanidzwa nechirwere chekuzvimba uye chinosiyana zvakanyanya mumwe nemumwe. Nonspecific zviratidzo zvinoratidzika kune zvakasiyana-siyana:

• fivha (fivha shoma);
• kubviswa;
• kuneta kusingaperi;
• kuderera kwekuita;
• kunetseka kuisa pfungwa;
• kunzwa kune zuva uye chiedza;
• alopecia;
• kunzwa kutonhora;
• kuoma kwemhino / nemuromo / kwemukadzi;
• maronda eganda;
• kuonda ;
• kurwadza kwemajoini;
• marwadzo kuzvimba tsandanyama (myalgia) uye majoini (arthralgia).

Dzimwe nguva varwere havana zviratidzo kunze kwekurwadziwa kwemajoini uye kuneta. Tinobva tataura nezve unifferentiated connectivitis. Dzimwe nguva zviratidzo zvemhando dzakasiyana dzezvirwere zvinosangana zvinoonekwa. Izvi zvinonzi overlap syndrome.

Nekuda kwekugona kukanganisa nhengo dzakawanda, zvakakosha kuti dzidziso dzakasiyana dzekurapa dzishande pamwe. Kuongororwa kunobva munhoroondo, kureva nhoroondo yemunhu anorwara, uye kuongororwa kwake kwekliniki, kutsvaga zviratidzo zvinowanzosangana mune imwe kana kupfuura yezvirwere izvi.

Sezvo ma collagenases achiratidzwa nehuwandu hukuru hwekugadzirwa kweantinuclear antibody, kuongororwa kweaya maautoantibodies muropa chinhu chakakosha mukutanga kuongororwa. Nekudaro, kuvepo kweaya maautoantibodies hakuwanzo kufanana ne collagenase. Dzimwe nguva zvakakoshawo kutora sampuli yetishu kana biopsy. Kuendesa kune nyanzvi kunokurudzirwa kusimbisa kuongororwa uye kutanga kurapwa kwakakodzera.

Chinangwa chekugadzirisa collagenosis ndechekudzora chiitiko chechirwere uye kuchidzikisa kusvika padanho rakaderera. Kurapa kunogadziriswa zvinoenderana nerudzi rwe collagenosis yakaonekwa uye zvinoenderana nenhengo dzakabatwa. Corticosteroids (cortisone) uye analgesics anowanzoshandiswa semutsara wekutanga kumisa kudzoka zvakare uye kudzikama kunorwadza kuratidzwa. Kuwedzerwa kwe immunosuppressant, nemuromo kana nejekiseni, zvingave zvakakosha. Kutarisira kunogonawo kusanganisira jekiseni remutsinga yeimmunoglobulins kana nzira dzekuchenesa plasma (plasmapheresis) munzvimbo yechipatara. Vamwe varwere, vakadai seavo vane lupus, vanogonawo kubatsirwa nekurapa marariya.