Kurapa kwakawanda kurapa varwere veCovid-19 kuri kudzidzwa pasi rese. Nhasi, nekuda kwekutsvagisa kwekurapa, varwere vanochengetwa zvirinani pane kutanga kwedenda re coronavirus. 

Clofoctol, molecule yakawanikwa neInstitut Pasteur de Lille

Kwidziridzo Ndira 14, 2021 - Hwaro hwakavanzika hwakamirira mvumo kubva kuvakuru vehutano kuti vatange miedzo yekiriniki yevanhu. Mushonga uyu ndeye clofoctol, uchiri kunyorerwa kusvika 2005 kurapa hutachiona hwekufema uye kutorwa sesuppository.

Iyo Pasteur Institute yeLille akaita chiwanikwa"fadzaPane imwe yemamorekuru maviri iri nyaya yetsvakiridzo yavo. Chikwata chinoumbwa nemasayendisiti "Task Force»Iine chinangwa chega chekutsvaga a mushonga unoshanda kurwisa Covid-19, kubvira pakatanga denda. Ari kuyedza kurapwa kwakati wandei kwatobvumidzwa uye kupindira kurapa mamwe ma pathologies. Prof. Benoît Déprez anozivisa kuti molecule "kunyanya inoshanda"Uye zvakazoitika"kunyanya ane simba"Kupikisa Sars-Cov-2, pamwe"tariro yekukurumidza kurapwa“. Iyo morekuru ine chekuita yave iri nyaya yekutevedzana kwebvunzo kubva pakutanga kwezhizha. Kubatsira kwayo kuri muchokwadi chekuti inotova nemvumo yekushambadzira, nekudaro ichichengetedza nguva yakawanda.

Mishonga inoshandiswa neInstitut Pasteur yakatotenderwa, izvo zvinovachengetedza nguva yakakosha. Iyo molecule ine chekuita ndeye anti-viral, iyo yakanga yatoshandiswa kurapa zvimwe zvirwere. Zita rake rakatanga kuvanzika ndokuzoziviswa, ndiye clofoctol. Vanamazvikokota vakasvika pakugumisa kuti kuita kaviri pachirwere : mushonga, wakatorwa nekukurumidza, kana zviratidzo zvekutanga zvaonekwa, zvinogona kuderedza huwandu hwehutachiona huripo mumuviri. Kana, pane zvinopesana, kurapwa kunotorwa kunonoka, kunogadzirisa kukura kwechimiro chakaoma. Iyi itariro huru, sezvo miedzo yepamberi yekiriniki pamacaque inogona kuburitswa muna Chivabvu.

Anti-inflammatory drugs inofanirwa kudzivirirwa kana paine Covid-19

Yakagadziridzwa munaKurume 16, 2020 - Maererano nekuongorora kwemazuva ano uye ruzivo rwakaparadzirwa nehurumende yeFrance, zvingaita sokuti kutora mishonga inorwisa-kupisa (Ibuprofen, cortisone, nezvimwewo) inogona kuva chinhu chinokonzera utachiona. Parizvino, miedzo yekiriniki uye mapurogiramu akati wandei eFrance neEurope ari kuyedza kunatsa kuongororwa uye kunzwisisa kwechirwere ichi kuitira kuvandudza manejimendi acho. Chero mamiriro ezvinhu, zvinowanzokurudzirwa kuti usatora anti-inflammatory drugs pasina mazano ekurapa kutanga.

Hapana marapiro chaiwo, asi marapiro akawanda ari kuongororwa. MuFrance, majekiseni mana akatenderwa, ayo ePfizer / BioNtech, Moderna, AstraZeneca naJanssen Johnson & Johnson. Imwe tsvagiridzo yekudzivirira anti-Covid iri kuitwa pasi rose.

Zvichakadaro, kune zvinyoro mafomu eCovid-19, kurapwa kune zviratidzo:

• Tora paracetamol yefivha uye kurwadza kwemuviri,
• Zorora,
• Inwa zvakanyanya kuti udzore mvura,
• Vhura mhino ne physiological saline.

Uye zvechokwadi,

• Kuzvivharira wega uye nekuremekedza matanho ehutsanana kudzivirira kusvibisa avo vakakukomberedza,

Muyedzo wekiriniki wekuEurope unosanganisira varwere 3.200 vakabatwa nechimiro chakanyanya kunotanga pakati paKurume kuitira kuenzanisa marapirwo mana akasiyana: okisijeni kurapwa uye kufema kufema maringe neremdesivir (antiviral kurapwa kwatoshandiswa kurwisa hutachiona hweEbola) maringe neKaletra (mushonga wekurwisa Ebola. utachiona). AIDS) inopesana neKaletra + beta interferon (morekuru inogadzirwa ne immune system kudzivirira zvirinani kutapukirwa nehutachiona) kusimbisa kuita kwayo. Chloroquine (mushonga wemarariya) wakambotaurwa pane imwe nguva hauna kuchengetwa nekuda kwenjodzi huru yekusangana kwezvinodhaka nemhedzisiro. Zvimwe zviedzo nemamwe marapiro zviri kuitwawo kune dzimwe nzvimbo pasi rose.

Varwere vanotapukirwa neiyo coronavirus nyowani vanorapwa sei?

Sechiyeuchidzo, Covid-19 chirwere chinokonzerwa nehutachiona hweSars-Cov-2. Chine zviratidzo zvakawanda, uye chinowanzo ratidza sefivha kana kunzwa fivha uye zviratidzo zvekutadza kufema zvakaita sekukosora kana kutadza kufema. Munhu akatapukirwa neCovid-19 anogona zvakare kuve asymptomatic. Nhamba yekufa yaizova 2%. Mhosva dzakakomba dzinowanzobata vanhu vakura uye / kana vanhu vanorwara nezvimwe zvirwere.

Kurapa kune zviratidzo. Kana uine chimwe kana kupfuura chezviratidzo zvechiratidzo, nenzira ine mwero, unofanira kufonera chiremba wako usati waenda kuhofisi yake. Chiremba anokuudza zvekuita (gara kumba kana kuenda kuhofisi yake) uye anokutungamira pamishonga yekunwa kuti ubvise fivha uye / kana kukosora. Paracetamol inofanira kutorwa kutanga kuderedza kupisa. Kune rumwe rutivi, kutora anti-inflammatory drugs (ibuprofen, cortisone) inorambidzwa nokuti inogona kuwedzera hutachiona.

Kana zviratidzo zvikawedzera nekunetseka kwekufema uye zviratidzo zvekudzipwa, fonera SAMU Center 15 iyo inosarudza zvekuita. Mhosva dzakakomba zvikuru dzinopinzwa muchipatara kuti dzibatsirwe nerubatsiro rwekufema, kuwedzera kutariswa kana kuti zvimwe kuiswa mukuchengetwa kwakanyanya.

Takatarisana nehuwandu hukuru hwezviitiko zvakakomba uye kupararira kwehutachiona pasirese, nzira dzinoverengeka dzekurapa dziri kuongororwa pari zvino kuitira kukurumidza kutsvaga kurapwa uye yekudzivirira.

Monoclonal antibody kurapwa

Musi waKurume 15, 2021, iyo French Medicines Agency, iyo ANSM yakabvumidza kushandiswa kwemaviri maviri ekurapa monoclonal kurapa Covid-19. Izvo zvakagadzirirwa vanhu vari panjodzi yekufambira mberi kune dzakakomba mafomu, "nekuda kwekudzivirira kwekudzivirira kwakabatana nechirwere chechirwere kana kurapwa, kwezera rekukura kana kuvapo kwecomorbidities". Mishonga inobvumirwa ndeiyi: 

• dual therapy casirivimab / imdevimab yakagadzirwa ne murabhoritari Rock;
• bamlanivimab / etesevimab dual therapy yakagadzirwa ne Lilly France murabhoritari.

Mishonga inopiwa kuvarwere muchipatara uye nekudzivirira, ndiko kuti, mukati memazuva mashanu mushure mekutanga kwezviratidzo. 

tocilizumab 

Tocilizumab ndeye monoclonal antibody uye inobata varwere vane yakakomba fomu yeCovid-19. Iyi morekuru inoita kuti zvikwanise kudzikamisa maitiro ekudzivirira muviri, imwe inobva yataura nezve "cytokine dutu". Uku kuwedzeredza kwekudzivirira kurwisa Covid-19 kunokonzera kunetseka kufema, kunoda rubatsiro.

Tocilizumab inowanzoshandiswa kurapa rheumatoid arthritis. Ndiwo maB lymphocytes anoburitsa masoja aya. Chidzidzo chakaitwa neAP-HP (Assistance Publique Hôpitaux de Paris), muFrance saka, pavarwere ve129. Ava varwere veCCIDID-19 vakatambura nechirwere chemapapu chine mwero kusvika chakanyanya. Hafu yevarwere yakapihwa mushonga wetocilizumab, mukuwedzera kurapwa kwakajairika. Vamwe varwere vose vakagamuchira kurapwa kwenguva dzose.  

Chekutanga cherechedzo ndechekuti huwandu hwevarwere vanogamuchirwa mukuchengetwa kwakanyanya hwadzikira. Chechipiri, nhamba yevakafa yakadererawo. Mhedzisiro yacho saka inovimbisa uye tariro yekurapwa pakurwisa coronavirus itsva ndeyechokwadi. Zvidzidzo zvichiri kuenderera mberi, sezvo mhedzisiro yekutanga iri kuvimbisa. 

Mhedzisiro yekutanga yezvimwe zvidzidzo (American neFrench) zvakaburitswa muJAMA mukati Mushonga, asi zvinopokana. Ongororo yeAmerica inoratidza kuti njodzi dzekufa kwevarwere vane yakanyanya Covid-19 dzinodzikiswa kana tocilizumab inopihwa mukati memaawa makumi mana nemasere mushure mekupinzwa muchikamu chevanorwara zvakanyanya. Chidzidzo cheFrench hachina mutsauko pakufa, asi chinoratidza kuti njodzi yekuve pane-isina-invasive kana mechanic ventilation yakaderera muvarwere vakagamuchira mushonga.

Discovery clinical trial: zvinodhaka zvatova pamusika

Iyo Institut Pasteur yakazivisa kugadzwa kwave pedyo kweyedzo yekiriniki inoyedzwa neInserm. Inotarisira "kuongorora uye kuenzanisa misanganiswa ina yekurapa":

Imwe neimwe ichave yakabatana neasina-chaiyo uye zviratidzo zvekurapa chirwere cheCovid-19.

• kurapwa kusiri-chaiyo uye kwechiratidzo chete.

Iri basa rinosanganisira mazana matatu nemakumi maviri evarwere vari muchipatara, kusanganisira mazana masere muFrance. Ichi chiedzo chekiriniki chichave chichifambira mberi. Kana imwe yemamolekemu akasarudzwa isingashande, inosiiwa. Sezvineiwo, kana mumwe wavo akashanda pane mumwe wevarwere, inogona kuongororwa kune vese varwere sechikamu chekuyedzwa.

« Chinangwa ndechekuongorora kushanda uye kuchengetedzeka kwemaitiro mana ekuyedza ekurapa anogona kuita kurwisa Covid-19 muchiedza che data razvino resainzi. »Sezvinoratidzwa neInserm.

Muyedzo weDiscovery uchatora chimiro nemaitiro mashanu ekurapa, akaedzwa zvisina tsarukano pavarwere vane yakanyanya coronavirus:

• mwero kutarisirwa
• standard care plus remdesivir,
• chiyero chekuchengetedza pamwe nelopinavir uye ritonavir,
• standard care plus lopinavir, ritonavir uye beta interferon
• chiyero chekuchengetedza pamwe nehydroxy-chloroquine.

Chii chinonzi remdesivir? 

Yakanga iri marabhoritari yeAmerica, Giriyedhi Sayenzi, iyo yakatanga kuyedza remdesivir. Chokwadi, mushonga uyu wakaedzwa kurapa varwere vane Ebola virus. Mhedzisiro yanga isati yakwana. Remdesivir is antiviral; chinhu chinorwisa mavhairasi. zvivai zvakadaro akapa mhedzisiro inovimbisa pane mamwe ma coronavirus. Ndicho chikonzero masayendisiti akasarudza kuedza mushonga uyu kurwisa hutachiona hweSars-Cov-2.

Zviito zvake ndezvipi? 

Iyi antiviral inodzivirira hutachiona kuti hurege kuberekana mumuviri. Le virus Sars-Cov-2 inogona kukonzera yakawandisa immune system mune vamwe varwere, inogona kurwisa mapapu. Apa ndipo panogona kuuya remdesivir, kudzora "cytokine dutu". Mushonga unozodzikamisa maitiro ekuzvimba uye nekudaro kukuvara kwemapapu. 

Migumisiroi? 

Remdesivir yakaratidzwa kuti varwere vane chimiro chakakomba cheCovid-19 vakapora nekukurumidza kupfuura avo vakagamuchira placebo. Iyo antiviral saka ine chiito chekurwisa hutachiona, asi haisi mushonga wakakwana wekurwisa chirwere. MuUnited States, kutonga kwechirwere ichi kunobvumirwa kushandiswa kwechimbichimbi.

MunaGunyana, zvidzidzo zvinoratidza kuti Remdesivir ingadai yakasimudzira kuporeswa kwevamwe varwere nemazuva mashoma. Remdesivir inotendwawo kuderedza kufa. Iyi anti-viral inoshanda chaizvo, asi, pachayo, haiumbe mushonga wekurwisa Covid-19. Zvisinei, nzira yacho yakakomba. 

Muna Gumiguru, zvidzidzo zvakaratidza kuti remdesevir yakaderedza zvishoma nguva yekupora kwevarwere veCovid-19. Zvisinei, zvingadai zvisina kuratidza chero rubatsiro mukuderedza kufa. Vakuru Vehutano Vehutano vakafunga kuti kufarira kwemushonga uyu kwaive "yakaderera".

Iyo Hycovid bvunzo yekurwisa iyo coronavirus nyowani

Muedzo mutsva wekiriniki, unonzi ” Hycovid Ichaitwa pavarwere ve1, kuunganidza mazana matatu ezvipatara muFrance. Vazhinji vavo vari kuMadokero: Cholet, Lorient, Brest, Quimper uye Poitiers; uye Kumaodzanyemba: Tourcoing neAmiens; muSouth-West: Toulouse neAgen; uye mudunhu reParis. Chipatara cheAngers University chiri kutungamira kuyedza uku.

Ndeipi protocol yemuyedzo weHycovid?

Muyedzo uyu une chekuita nevarwere vane Covid-19, kwete munzvimbo yekushushikana, kana mukuchengetwa kwakanyanya asi panjodzi huru yekunetseka. Muchokwadi, vazhinji vevarwere vakaiswa mukuyedzwa vangave vakura (vane makore makumi manomwe neshanu) kana vane matambudziko ekufema, nekuda kweokisijeni.

Kurapa kunogona kupihwa kuvarwere vakananga kuchipatara, mumisha inochengeterwa vakwegura kana kumba. Sezvinoratidzwa naProfessor Vincent Dubee, muvambi mukuru wechirongwa ichi paAngers University Hospital, “Ticharapa vanhu nguva ichiripo, izvo zvingangove ndizvo zvinotaridza kubudirira kwekurapa”. Pamusoro pekutsanangura kuti mushonga hauzonzi kune vese nekuti vamwe varwere vanogashira placebo, pasina murwere, kana chiremba achizviziva.

Mibairo yekutanga  

Pfungwa huru yaProfessor Dubee ndeye "kuvhara gakava" pamusoro pekushanda, kana kwete, kwechloroquine. Protocol yakasimba iyo ichapa mhedzisiro yayo yekutanga mukati memazuva gumi nemashanu, nemhedziso inotarisirwa mukupera kwaApril.

Chloroquine yekurapa coronavirus?

Pr Didier Raoult, nyanzvi yechirwere chinotapukira uye purofesa we microbiology paInstitut Hospitalo-Universitaire Méditerranée utachiona muMarseille, vakaratidza muna Kukadzi 25, 2020 kuti chloroquine inogona kurapa Covid-19. Mushonga unodzivirira marariya uyu ungadai wakaratidza kushanda kwawo mukurapa chirwere ichi, sekureva kweongororo yesainzi yekuChina yakaburitswa mupepanhau reBioScience Trends. Sekureva kwaProfessor Raoult, chloroquine "yaizove neshanduko yemabayo, kugadzirisa mamiriro emapapu, kuitira kuti murwere asaite hutachiona zvakare uye kupfupisa nguva yechirwere". Vanyori vechidzidzo ichi vanosimbirirawo kuti mushonga uyu haudhure uye mabhenefiti / njodzi dzawo dzinozivikanwa nekuti wanga uri pamusika kwenguva yakareba.

Iyi nzira yekurapa inofanirwa kudzikiswa nekuti zvidzidzo zvakaitwa pavarwere vashoma uye chloroquine inogona kukonzera njodzi. Hydroxycloroquine haichashandiswe muFrance, sechikamu cheCovid-19, kunze kwekunge iine chekuita nevarwere vaive chikamu chekuyedzwa kwekiriniki. 

Kushandiswa kwemaserum kubva kuvanhu vakaporeswa

Iko kushandiswa kwesera kubva kune convalescents, kureva kubva kuvanhu vakatapukirwa uye vakagadzira masoja ekudzivirira chirwere, zvakare inzira yekurapa iri kuongororwa. Tsvagiridzo yakaburitswa muJournal yeClinical Investigation inoratidza kuti kushandisa convalescent sera kunogona:

• kudzivirira vanhu vane hutano vanosangana nehutachiona kubva pakuita chirwere;
• rapa avo vanoratidza zviratidzo zvekutanga nekukurumidza.

Vanyori vechidzidzo ichi vanorangarira kukosha kwekuchengetedza vanhu vanonyanya kuratidzwa kuCovid-19, kunyanya vashandi vehutano. “Nhasi, vanamukoti, vanachiremba nevamwe vashandi vehutano vari pamberi mukurwisa Covid-19. Vanooneswa kumatare edzimhosva. Vamwe vavo vakagadzira chirwere ichi, vamwe vakagariswa vari vega senzira yekudzivirira, zvichikanganisa hutano hwehutano hwenyika dzakanyanya kubatwa.”, Pedzisa vaongorori.

Nicotine ingave nemhedzisiro yakanaka pahutachiona hweCovid-19? Izvi ndizvo zviri kuyedza kutsvaga nechikwata kubva kuchipatara chePitié Salpêtrière. Chekutarisa ndechekuti vanhu vashoma vabatwa neCovid-19 vanoputa. Sezvo midzanga ine chepfu yakadai searsenic, ammonia kana carbon monoxide, vatsvakurudzi vari kutendeukira kuchikakananda. Iyi psychoactive substance inonzi inodzivirira kuti utachiona husazvisungirira kumadziro emasero. Ngwarira, zvisinei, kuti nenzira ipi neipi hairevi kuti unofanira kusvuta. Midzanga inokuvadza hutano uye inokuvadza zvakanyanya mapapu.

Izvi zvinosanganisira kushandisa nicotine zvigamba kune mamwe mapoka evanhu:

• mukoti, yekudzivirira uye kudzivirira basa re nicotine;
• varwere vari muchipatara, kuona kana zviratidzo zviri nani;
• kune dzakakomba nyaya dzeCovid-19, kuderedza kuzvimba. 

Chidzidzo ichi chiri kuenderera mberi kuratidza mabatiro enicotine paiyo coronavirus itsva, ingave nekudzivirira kwete basa rekurapa.

Kwidziridzo yaMbudzi 27 - Iyo Nicovid Prev kudzidza, inoyedzwa neAP-HP, ichawedzera nyika yese uye inosanganisira vanopfuura 1 mukoti. Nguva ye "kurapa" ichave pakati pe500 ne4 mwedzi.

Kwidziridzo Gumiguru 16, 2020 - Mhedzisiro yenicotine paCovid-19 ichiri fungidziro panguva ino. Nekudaro, Santé Publique France inokurudzira zvirongwa zvese kurwisa coronavirus. Migumisiro yakamirirwa nechido.

Sezvo iyo SARS-CoV-2 coronavirus iri nyowani, hapana nzira yekuwedzera yakasimbiswa. Izvo zvakadaro zvinogoneka kuedza kusimbisa kusadzivirirwa kwayo nemiti inokurudzirwa kana furuwenza yemwaka:

• Ginseng: inozivikanwa kukurudzira immune system. Kudya mangwanani, ginseng inobatsira kurwisa kuneta kwemuviri kubatsira kuwanazve simba. Chiyero chinosiyana kubva kune imwe nyaya kuenda kune imwe nyaya, bvunza chiremba wako kuti agadzirise dosage. 
• Echinacea: inobatsira kuderedza zviratidzo zvechando. Zvakakosha kutora echinacea pachiratidzo chekutanga chechirwere chepamusoro chekufema (kutonhora, sinusitis, laryngitis, nezvimwewo).
• Andrographis: zvine mwero inoderedza nguva uye kusimba kwezviratidzo zvechirwere chekufema turakiti (chando, furuu, pharyngitis).
• Eleutherococcus kana black elderberry: kurudzira immune system uye kuderedza kuneta, kunyanya panguva yefuruwenza syndrome.

Kune rimwe divi, kutora vhitamini D kunogona kuderedza njodzi yeacute kufema kutapukira nekuwedzera kusadzivirirwa (6). Chidzidzo kubva mumagazini inonzi Minerva, Ongororo yeEvidence-Yakavakirwa Mushonga inotsanangura kuti: Vitamin D yekuwedzera inogona kudzivirira acute kufema turakiti zvirwere. Varwere vanonyanya kubatsirwa ndeavo vane kushayikwa kwevhitamini D kwakanyanya uye avo vanogamuchira zuva nezuva kana vhiki rega rega. "Saka zvakakwana kutora madonhwe mashoma evhitamini D3 zuva rega rega kusvika 1500 kusvika 2000 IU pazuva (IU = mayuniti epasi rose) kuvanhu vakuru uye 1000 IU pazuva kuvana. Izvo zvakakosha zvikuru kutevera mazano echiremba anorayira, kuti urege kuva nehuwandu hwevhitamini D. Mukuwedzera, vitamin supplementation haisunungurwi kubva pakuremekedza maitiro ekudzivirira. 

Kudzidzira muviri

Kuita maekisesaizi kunopa simba rokuzvidzivirira. Ichi ndicho chikonzero chinoderedza zvese njodzi yehutachiona uye cancer. Saka, kuti uzvidzivirire kubva kukoronavirus, senge hutachiona hwese, kurovedza muviri kunokurudzirwa zvakanyanya. Ngwarira, zvisinei, kuti usatamba mitambo kana une fivha. Muchiitiko ichi, zvakakosha kuzorora nokuti njodzi ye infarction inoratidzika kuwedzera muchiitiko chekuedza munguva yefivha. Iyo yakanakira "dose" yekurovedza muviri pazuva kuti uwedzere kusadzivirirwa kwaizove kutenderera maminetsi makumi matatu pazuva (kana kusvika paawa).