La Chirwere cheCrohn ndiwo chirwere chisingaperi chinoputika of the digestive system (guru guru), iro rinoshanduka nekuzaruka uye zvikamu zvekuregererwa. Inoratidzirwa zvakanyanya nematambudziko e marwadzo emudumbu uye chirwere, iyo inogona kupedza vhiki dzinoverengeka kana mwedzi yakati wandei. Kuneta, kuonda uye kunyange kushomeka kwekudya kunovaka muviri kunogona kuitika kana pasina kurapwa kunoitwa. Mune zvimwe zviitiko, zviratidzo zvisiri zvekugaya, iyo inokanganisa ganda, majoini kana maziso angave akabatanidzwa nechirwere. 

Unoziva sei zviratidzo zveCrohn's disease? 

Kana iwe une Chirwere cheCrohn, kuzvimba kunogona kukanganisa chero chikamu chekudya, kubva pamuromo kusvika kune anus. Asi kazhinji inogadzika panosanganaura hudiki uye colon (hura huru).

Mufananidzo weCrohn's disease

Ndezvipi zvikonzero zveCrohn's disease?

La Chirwere cheCrohn imhaka yekuramba ichizvimba madziro uye yakadzika akaturikidzana chirwere chekudya. Kuzvimba uku kunogona kutungamira mukukora kwemadziro mune dzimwe nzvimbo, makatsemuka uye maronda mune dzimwe. Zvikonzero zvekuzvimba hazvizivikanwe uye zvinogona kunge zvakawandisa, zvinosanganisira genetic, autoimmune uye zvakatipoteredza zvinhu.

Genetic factors

Kunyange zvazvo chirwere cheCrohn chisati chiri chirwere chemajini, mamwe majini anogona kuwedzera mikana yekuiwana. Mumakore achangopfuura, vaongorori vakawana akati wandei susceptibility majini, kusanganisira iyo NOD2 / CARD15 gene, iyo inowedzera mukana wekuita chirwere kanokwana kana kashanu.⁶. Jeni iri rine basa mukudzivirira kwemuviri. Zvisinei, zvimwe zvinhu zvinodiwa kuti chirwere ichi chiite. Sezvimwe mune zvimwe zvirwere zvakawanda, zvinoratidzika kuti mavambo emajini akasanganiswa nemamiriro ezvinhu ezvakatipoteredza kana mararamiro ndiwo anokonzera chirwere chacho.

Autoimmune zvinhu

Kufanana neulcerative colitis, chirwere cheCrohn chine maitiro echirwere che autoimmune (= chirwere apo immune system inorwisa masero ayo). Vatsvaguri vanotenda kuti kuzvimba kwegumbo rekudya kunoenderana nekuwanda kwemuviri kwemasoja ekudzivirira kubva kumavhairasi kana mabhakitiriya ari muura.

Environmental factors

Zvinocherechedzwa kuti chiitiko chechirwere cheCrohn chakakwira mukati nyika dzakabudirira uye yakada kuwedzera kubva muna 1950. Izvi zvinoratidza kuti mamiriro ezvakatipoteredza, zvichida akabatanidzwa kuMadokero mararamiro ehupenyu, angave ane simba guru pakutanga kwechirwere. Zvisinei, hapana chainyatsozivikanwa chisati chazivikanwa. Nzira dzinoverengeka dziri kudzidzwa. Kuratidzwa kune mamwe maantibioti, kunyanya kubva mukirasi yetetracycline, inogona kukonzera njodzi³¹. Vanoputa fodya vari panjodzi huru yekubatwa nechirwere ichi. Vanhu vakanyanya kugara vanobatwa zvakanyanya kupfuura vanhu vanoshingaira³².

Zvinogoneka, asi hapana humbowo hwakakwana, kuti kudya kwakapfuma zvakanyanya mumafuta akaipa, nyama uye shuga kunowedzera njodzi.³³. 

Vatsvakurudzi vari kunyanya kutarisa basa rinogona kuitwa nehutachiona ne utachiwana kana bacterium (salmonella, campylobacter) mukukonzera chirwere. Pamusoro pekutapukirwa ne “external” microbe, a ura hwepamuviri kusaenzana (kureva kuti utachiona hunowanikwa mudumbu) hunogonawo kuve nechekuita¹⁸.

Mukuwedzera, mamwe maelementi anoita seanoshandisa kudzivirira. Izvi zvinosanganisira chikafu chakapfuma mufiber nemichero, kusangana usati wasvika gore nekatsi kana mhuka dzepapurazi, appendectomy, pamwe nekuve negastroenteritis kana hutachiona. kufema³⁴. Iko hakuna zvakare kushamwaridzana pakati peMMR (measles-rubella-mumps) yekudzivirira uye chirwere cheCrohn.³⁵.

Psychological zvinhu

Zvagara zvichifungwa kuti kushushikana mupfungwa kunogona kukonzera pfari. Nekudaro, ongororo dzakaitwa kusvika parizvino dzinoratidza kupikisa iyi hypothesis.

Vanhu vari panjodzi

• Vanhu vane nhoroondo yemhuri kuzvimba bowel chirwere (chirwere cheCrohn kana ulcerative colitis). Izvi zvingava nyaya ye10% kusvika 25% yeavo vakabatwa.
• Vamwe vanhu vari panjodzi kupfuura vamwe, nekuda kwemajini avo. Nharaunda yechiJudha (yeAshkenazi yakabva), somuenzaniso, yaizova 4 kusvika ku5 nguva yakawanda yakabatwa neCrohn's disease.^3,4.

Chirwere cheCrohn chinowedzera sei?

Icho chirwere chisingaperi chiripo muupenyu hwose. Kazhinji kazhinji Chirwere cheCrohn inoshanduka mumoto unopindirana nenguva dzekuregererwa dzinogona kugara kwemwedzi yakati wandei. Inenge 10% kusvika 20% yevanhu vane kuregererwa kusingaperi mushure mekutanga kwechirwere. The zvinodzokororwa (kana matambudziko) anoteverana nenzira isingatarisike uye ane hukuru hwakasiyana. Dzimwe nguva zviratidzo zvakanyanyisa (kusakwanisa kudya, kubuda ropa, manyoka, nezvimwewo) zvokuti kuchipatara kunodiwa.

Zvinetso zvinogoneka nemhedzisiro

La Chirwere cheCrohn zvinogona kutungamirira kumatambudziko akasiyana-siyana ehutano. Zvisinei, kuoma kwezviratidzo uye zvinetso zvinosiyana zvikuru pamunhu nomunhu.

Zvinogona kuitika

• A kuvharika kwegumbo rekudya. Kuzvimba kwenguva refu kunogona kukonzera kuti marara emudumbu aite gobvu, izvo zvinogona kutungamira mukuvharika kwechikamu kana kuzara kwegumbo rekudya. Izvi zvinogona kutungamirira kukuputika, kuvimbiswa, kana kunyange kurutsa kwetsvina. Emergency hospitalization ingave yakakosha kudzivirira kuputika kweura.
• Maronda ari mukati megumbo rekudya.
• Maronda akapoteredza anus (fistulas, kutsemuka kwakadzika kana maabscesses asingaperi).
• Kubuda ropa kubva mudumbu, kushoma asi dzimwe nguva kwakakomba.
• Vanhu vane chirwere cheCrohn chekoroni vane ngozi shoma yekuva nekenza yekoloni, kunyanya mushure memakore akawanda echirwere, uye kunyange kana vari kurapwa. Saka zvinokurudzirwa kukurumidza uye kuongororwa gomarara remukati.

Zvinogona kuitika

• A kushaya utano, nokuti munguva dzematambudziko, varwere vanowanzodya zvishoma nekuda kwemarwadzo. Pamusoro pekukwanisa kutora chikafu kuburikidza nemadziro emukati kunokanganiswa, mumutauro wekurapa tinotaura nezve malabsorption.
• Un kunonoka kukura uye kuyaruka muvana nevachiri kuyaruka.
• Iron kuperevedza anemia, nekuda kwekubuda ropa mudumbu rekudya, izvo zvinogona kuitika muruzha rwakaderera uye zvisingaoneki nemeso.
• Mamwe matambudziko ehutano, akadai searthritis, mamiriro eganda, kuzvimba kwemaziso, maronda emumuromo, matombo eitsvo kana gallstones.
• Chirwere cheCrohn, kana chiri muchikamu che "chinoshanda", chinowedzera njodzi yekubvisa pamuviri muvakadzi vane pamuviri vanazvo. Zvinogona kuita kuti zvive zvakaoma kuti fetus ikure. Saka zvakakosha kuti vakadzi vanoda kuve nepamuviri vadzore chirwere chavo nerubatsiro rwemishonga uye nekuchikurukura nachiremba wavo.

Vanhu vangani vanobatwa nechirwere cheCrohn?

Maererano newebsite yeAfa, iri kuNorthwest Europe uye United States kuti tinowana vanhu vakawanda vanobatwa neCrohn's disease. MuFrance, vanenge 120.000 vanhu vanonzi vari kukanganiswa. Mumatunhu aya, iyo Afa inoverenga 4 kusvika ku5 makesi pa100.000 vagari gore rega rega. 

 MuCanada, the Chirwere cheCrohn inokanganisa vanhu vangangosvika makumi mashanu pahuwandu hwevanhu zana vari munyika dzakabudirira, asi kune musiyano mukuru wenzvimbo. Nzvimbo yepasirese ine nyaya dzakanyanya kutaurwa iri muNova Scotia, dunhu reCanada, uko mwero unokwira kusvika pazviuru zvevanhu pa50. MuJapan, Romania neSouth Korea, mwero uri pasi pe100 pa000²⁹.

Chirwere chinogona kuitika pazera ripi neripi, kusanganisira pauduku. Inowanzoonekwa muvanhu vane makore gumi kusvika makumi matatu³⁰.

Maonero echiremba wedu pachirwere

Sechikamu chemaitiro ayo emhando, Passeportsanté.net inokukoka iwe kuti uwane maonero enyanzvi yehutano. Dr Dominic Larose, chiremba wekukurumidzira anokupa maonero ake pane Chirwere cheCrohn :