Cushing's syndrome chirwere che endocrine chakabatana nekuratidzwa kwemuviri kune akanyanya mwero ecortisol, mahormone akavanzwa neadrenal glands. Hunhu hwayo hwakanyanya kufutisa kwemuviri wepamusoro uye kumeso kwemunhu akabatwa. Mune akawanda kesi, Cushing's syndrome inokonzerwa nekutora inorwisa-kupisa mishonga. Asi inogona zvakare kuve nechikonzero chekusingaperi kwekutanga, senge chirwere chaCushing, chinove chisingawanzoitika, kubva pagumi kusvika pagumi nematatu emakesi matsva pamamiriyoni evanhu uye pagore, sekureva. (1)

Asina kujairika akakwirisa ecortisol mazinga anokonzera kuwanda kwezviratidzo nezviratidzo. Chinonyanya kurova ndeichi kuwedzera uremu uye shanduko pakuonekwa kwemunhu anorwara: mafuta anoungana mumuviri wepamusoro nemutsipa, kumeso kunova kutenderera, kuzvimba uye kutsvuka. Izvi zvinowirirana nekurasikirwa nemhasuru mumaoko nemumakumbo, kusvika padanho rekuti "atrophy" iyi inogona kukanganisa kufamba kwemunhu akabatwa.

Zvimwe zviratidzo zvinoonekwa sekutetepa kweganda, kutaridzika kwekutambanuka (padumbu, zvidya, magaro, maoko nemazamu) uye maronda pamakumbo. Iko kukanganisa kwakakomba kwepfungwa nekuda kweiyo cerebral chiito checortisol hakufanirwe kuregeredzwa chero: kuneta, kushushikana, kusagadzikana, kurara uye kushushikana kwekushushikana uye kushushikana kunokanganisa hupenyu hwehupenyu uye kunogona kutungamira kuzviuraya.

Vakadzi vanogona kukura mburwa uye kunyanya kuwanda kwebvudzi kukura uye kusangana nekuenda kumwedzi kukanganiswa, nepo varume pabonde uye kubereka kuderera. Osteoporosis, hutachiona, thrombosis, kuwedzerwa kweropa uye chirwere cheshuga zvinowanzoitika matambudziko.

Cushing's syndrome inokonzerwa nekunyanyisa kuburitsa matishu mumuviri kune steroid mahormone, kusanganisira cortisol. Cushing's syndrome kazhinji inoguma nekutora synthetic corticosteroids kune avo anti-anogumbura mhedzisiro mukurapa asthma, zvirwere zvinoputira, nezvimwewo, nemuromo, sekupfapfaidza kana sechizoro. Izvo zvino zvekunze kwakatangira.

Asi mabviro ayo anogona kuve endo native: iyo syndrome inokonzereswa nekunyanyisa kwekuvharisa kwecortisol neimwe kana zvese zviri zviviri adrenal gland (iri pamusoro peitsvo). Izvi zvinoitika kana bundu, benign kana rakaipa, rikakura mune adrenal gland, mune iyo pituitary gland (iri mudehenya), kana kumwe kunhu mumuviri. Kana Cushing's syndrome ichikonzerwa nebundu rinotyisa pituitary gland (a pituitary adenoma), inonzi chirwere cheCushing. Bundu rinoburitsa yakawandisa corticotropin kemikari ACTH iyo inomutsa adrenal gland uye zvisina kunangana nekunyanyisa kuchengetedzwa kwecortisol. Chirwere cheCushing chinoita makumi manomwe muzana ezviitiko zvese zvisingagumi (70)

Mazhinji kesi eCushing's syndrome haana kugarwa nhaka. Nekudaro, izvi zvinogona kuitika nekuda kweyakagara nhaka maitiro ekuvandudza mabundu mune endocrine, adrenal, uye pituitary gland.

Vakadzi vane mukana wakapetwa kashanu pane varume kuwana Cushing's syndrome inokonzerwa neadrenal kana pituitary bundu. Kune rimwe divi, varume vanowoneka zvakapetwa katatu kupfuura vakadzi kana honzeri iri kenza yemapapu. (2)

Icho chinangwa chechero kurapwa kweCushing's syndrome kudzokororazve kudzora kwakanyanya kwecortisol. Kana Cushing's syndrome ichibatwa-nezvinodhaka, endocrinologist inogadzirisa iyo causal kurapwa. Kana chiri mhedzisiro yebundu, kurapwa nekuvhiya (kubviswa kweadenoma mune pituitary gland, adrenalectomy, nezvimwewo), radiotherapy uye chemotherapy, zvinoshandiswa. Kana zvisingaite kubvisa zvachose bundu rinokonzera, mishonga inodzivirira cortisol (anticortisolics) kana inhibitors yehomoni ACTH inogona kushandiswa. Asi ivo vakaomarara kuita uye avo mhedzisiro mhedzisiro inogona kuve yakaoma, kutanga nenjodzi yekushomeka kweAdrenal.