Le fibrinogen ndiwo protein ropa iro rinoita basa mu kuwedzeredza. Anotora chikamu mukudzidziswa kwe ropa clots uye zvakare modulates basa reropa maplatelet uye chitokisi ye midziyo. Pasi pekuita kweimwe puroteni, iyo thrombin, inoshanduka kuita fibrin

Inogadzirwa nemasero echiropa. Chiyero chayo muropa chinowanzosiyana kubva 2 kusvika 4 g / l. Nekudaro, iyo synthesis yeizvi protein inogona kuwedzera semugumisiro wekushungurudzika, panguva yekuzvitakura, kana mushure mekupinza mamwe mishonga kana kukura kwehomoni. Kuwedzera kwehuwandu hwefibrinogen muropa kunoratidzawo mamiriro ekupisa.

Iyo fibrinogen assay inoratidzwa kuti iongorore chirwere chekuvhara ropa (semuenzaniso kana kubuda ropa kusingatsananguriki kana ” defibrination syndrome », Zvinoenderana ne coagulation abnormality).

Kune matatu ekuremara kwekuzvarwa mumazinga efibrinogen:

• THEafibrinogenemia, ndiko kusavapo zvachose kwefibrinogen. Ichi chirwere chisingawanzoitiki chinokonzera kubuda ropa kwakanyanya kunoitika kubva pakuberekwa
• THEhypofibrinogenemia, inofananidzwa nekuderera kwehuwandu hwefibrinogen muropa (ichi chikanganiso mukuvanzika, kazhinji kazhinji)
• La dysfibrinogenemia, kunova kusakwana kweprotein.

Ropa fibrinogen bvunzo inogona zvakare kubatsira muzviitiko zve:

• immune syndrome
• kukundikana kwechiropa (zvichikonzera kuderera kwemazinga efibrinogen)
• kutarisa mhedzisiro yeanonzi "fibrinolytic" kurapa, inotarisirwa kunyungudutsa ropa clot muchiitiko che thrombosis.

Muyero we fibrinogen inoitwa pamuenzaniso weropa re venous (blood test), murabhoritari yekuongorora yezvokurapa. Chiyero chiyero chenguva dzose uye mhedzisiro inowanzowanikwa mukati mezuva.

Chiremba ndiye chete anogona kududzira mhedzisiro yekuongorora.

Kazhinji, kuwanda kwefibrinogen (hyperfibrinogenemia) inogona kuonekwa munyaya yekuputika, kana kune zvimwe zvirwere zvinotapukira (pneumonia, nezvimwewo), kana rheumatic fever kana autoimmune zvirwere (lupus), mushure mokunge myocardial infarction, nezvimwewo.

Sezvineiwo, hypofibrinogenemia (kuderera kwefibrinogen level) inogona kuratidza chirwere chemajini, kukundikana kwakanyanya kwechiropa (hepatitis, cirrhosis), coagulation kusagadzikana (kuparadzira intravascular coagulation kana defibrination syndrome) kana "fibrinolysis", semuenzaniso nekuda kwekenza.