Chikonzero chenguva dzose chekubvunzana, hyperandrogenism inoreva kuwandisa kwemahomoni echirume mumukadzi. Izvi zvinoratidzwa nezvakawanda kana zvishoma zviratidzo zvevirilization.

Muvakadzi, mazai uye adrenal glands zvinowanzobudisa testosterone, asi zvishoma. Inowanzo kuwanikwa pakati pe0,3 uye 3 nanomoles parita yeropa, zvichienzaniswa ne8,2 kusvika 34,6 nmol / L muvanhu.

Isu tinotaura nezve hyperandrogenism kana chiyero chehomoni iyi chakakwirira kudarika chinowanzo. Zviratidzo zvevirilization zvinogona kuzoonekwa: 

• hyperpilosite;
• mburwa;
• mhanza;
• tsandanyama hypertrophy, nezvimwewo.

Mhedzisiro yacho haisi yekunaka chete. Inogonawo kuva yepfungwa uye yemagariro. Mukuwedzera, kuwandisa kwe testosterone kunogona kukonzera kusabereka uye nyaya dzemetabolism.

Inogona kutsanangurwa nezvikonzero zvakasiyana-siyana, iyo inowanzova inotevera.

Ovarian dystrophy

Izvi zvinotungamirira ku polycystic ovary syndrome (PCOS). Izvi zvinobata anenge 1 muvakadzi gumi. Varwere vanowana pathology yavo mukuyaruka, pavanobvunza dambudziko re hyperpilosity uye yakakomba mburwa, kana gare gare, pavanosangana nekushaya mbereko. Izvi zvinodaro nekuti testosterone yakawandisa inogadzirwa nemaovary inokanganisa kukura kweiyo ovarian follicles, iyo isingakure zvakakwana kuburitsa mazai avo. Izvi zvinoratidzwa nekuvhiringidzika kwekuenda kumwedzi, kana kunyange nekushaya nguva (amenorrhea).

Congenital adrenal hyperplasia

Ichi chisingawanzo genetic chirwere chinotungamira kune adrenal dysfunction, kusanganisira kuwanda kwemahomoni echirume uye underproduction ye cortisol, iyo hormone inoita basa rakakura mumetabolism yemacarbohydrates, mafuta uye mapuroteni. Muchiitiko ichi, hyperandrogenism inofambidzana nekuneta, hypoglycemia uye kudonha kweropa. Iyi pathology inowanzozviratidza kubva pakuzvarwa, asi mune zvimwe zviitiko zvine mwero inogona kumirira kusvika munhu mukuru kuti azviratidze. 

Bundu pane adrenal gland

Zvakanyanya kushoma, zvinogona kutungamirira kune yakawandisa secretion yemahomoni echirume, asiwo cortisol. Hyperandrogenism inobva yaperekedzwa ne hypercorticism, kana Cushing's syndrome, iyo inokonzera arterial hypertension.

Bundu reovarian rinoburitsa mahormone echirume

Ichi chikonzero hachiwanzo.

Kusvitsa

Sezvo kugadzirwa kwemahomoni echikadzi kwakadzikira zvakanyanya, mahormone echirume ane nzvimbo yakawanda yekuzvitaura. Dzimwe nguva izvi zvinotungamirira kukuregererwa, nezviratidzo zvakakosha zvevirilization. Chete kuongororwa kwekiriniki kwakabatana nekuongororwa kwehomoni, ine dosi ye androgens, inogona kusimbisa kuongororwa. An ultrasound yemaovari kana adrenal glands inogonawo kurairwa kuti ijekese chikonzero.

Zviratidzo zvekliniki zvinoratidza hyperandrogenism ndezvi:

• hirsutism : bvudzi rakakosha. Kunyanya, vhudzi rinoonekwa munzvimbo dzemuviri dzinowanzove dzisina bvudzi muvakadzi (chiso, torso, dumbu, kuzasi kumashure, matako, mukati mehudyu), iyo inogona kuve yakakosha yepfungwa nemagariro. ;
• acne et iyo seborrhee (ganda rine mafuta); 
• alopecia mhanza yechirume, ine bvudzi rakawanda rakarasika kumusoro kwemusoro kana kumberi.

Izvi zviratidzo zvinogona zvakare kusanganiswa ne:

• kusagadzikana kwekuenda kumwedzi, pamwe nekusavapo kwenguva (amenorrhea), kana kuti yakareba uye isina kukwana (spaniomenorrhea);
• kuwedzera kweclitoral (clitoromegaly) uye kuwedzera libido;
• zvimwe zviratidzo zvevirilization : izwi rinogona kuwedzera kukomba uye musculature inorangarira murume morphology.

Kana yakanyatso cherechedzwa, hyperandrogenism inogona kutungamirira kune mamwe matambudziko akareba:

• metabolic matambudziko : kuwandisa kwemahomoni echirume kunokurudzira kuwedzera uye kukura kwe insulin kushorwa, saka njodzi yekufutisa, chirwere cheshuga uye chirwere chemoyo;
• gynecological matambudziko, kusanganisira kuwedzera kwengozi yekenza ye endometrial.

Ichi ndicho chikonzero hyperandrogenism haifaniri kuonekwa chete kubva pakuona kwezvizoro. Zvingada kurapwa.

Kutungamira kunoenderana chekutanga pane zvese chikonzero.

Kana iri bundu

Kuvhiya kunodiwa kuti ubvise.

Kune polycystic ovary syndrome

Iko hakuna kurapwa kwekudzivirira kana kurapa iyi syndrome, kurapwa chete kwezviratidzo zvayo.

• Kana murwere asingaiti kana vana vakawanda, kurapwa kunosanganisira kuisa maovary kuzorora, kuderedza kugadzirwa kwavo kwemahomoni echirume. Piritsi yeestrogen-progestin inorayirwa. Kana izvi zvisina kukwana, mushonga unorwisa-androgen unogona kupiwa sekuwedzera, cyproterone acetate (Androcur®). Zvisinei, sezvo chigadzirwa ichi chave chichangobva kubatanidzwa nengozi ye meningioma, kushandiswa kwayo kunongogumira kumatambudziko akaoma zvikuru, ayo anobatsira / njodzi inowanikwa zvakanaka;
• Panyaya yekuda kubata pamuviri nekushaya mbereko, kukurudzirwa kuri nyore kwe ovulation kunokurudzirwa nekutanga-mutsara clomiphene citrate. Ongororo yekushaya mbereko inoitwa kuona kusavapo kwezvimwe zvinhu zvinobatanidzwa. Kana kukurudzirwa kwezvinodhaka kusashanda, kana kana zvimwe zvikonzero zvekusabereka zvakawanikwa, intrauterine insemination kana in vitro fertilization inofungidzirwa. 

Kubviswa kwebvudzi reLaser kunogona zvakare kupihwa kudzikisa kukura kwebvudzi uye emuno dermatological kurapwa kurwisa mburwa.

Muzviitiko zvose, tsika yemutambo uye kutevera kwekudya kwakakwana kunorayirwa. Muchiitiko chekurema, kurasikirwa kweanenge 10% yehuremu hwekutanga kunoderedza hyperandrogenism uye matambudziko ayo ose. 

Kana iri adrenal hyperplasia

Kana chirwere ichi chiri genetic, kunyatsotarisirwa kunoiswa munzvimbo idzo dziri nyanzvi dzezvirwere zvisingawanzo. Kurapa kunosanganisira corticosteroids kunyanya.