Macrophage myofasciitis inoratidzwa ne histopathological lesions (chirwere chinokanganisa matishu). Aya ndiwo mhedzisiro yemyopathological, kureva kuti inokanganisa tsandanyama.

Chirwere ichi chakatsanangurwa zvichitevera kuongororwa kwemunhu, kubva kumurwere mukuru uye muvana vatatu. Kukuvadza mukati memhasuru fibers kwakaratidzwa pasina kuvepo kwenecrosis. Kuongororwa kwezvironda izvi (nuclear microprobes, radiographic microanalyses, atomic absorption spectrometry) yakaita kuti zvikwanise kunzwisisa kuti kukuvara uku kwakaumbwa nealuminium munyu. Izvi zvinhu zvinoshandiswa zvakanyanya munhamba huru yejekiseni inopihwa intramuscularly. Zvakaratidzawo kuti hapana chikonzero chaikonzera chirwere ichi. Zvechokwadi, vanhu vane utano hwakanaka (kwete kurwara, kuva nemararamiro ane hutano, nezvimwewo) vanogona kukanganiswa nechirwere chinotevera nhomba. (3)

Pakutanga, mavambo chaiwo echirwere akanga asingazivikanwi. Kufungira pamusoro pezvakatipoteredza, kutapurirana uye chimwe chikonzero zvakanga zvasimudzwa. Basa reSainzi rakaitwa pakati pa1998 na2001 rakaratidza kuti chainyanya kukonzera chirwere kwaive kutorwa kwealuminium hydroxide iripo mumajekiseni. Microscopic imaging miedzo yezvikamu zvemukati: macrophages yakaratidza kuvapo nguva dzose ye inclusions inokonzerwa nea aluminium salts. Mishonga iyi inoshandiswa sezviyereso mumajekiseni. Macrophage myofasciitis inowanikwa chete mu deltoid muvanhu vakuru uye mu quadriceps muvana.

Zviratidzo zvikuru zvinosangana nechirwere ndezvizvi:

- kurwadziwa kusingaperi mumasumbu: kukura kwayo kunononoka (kwenguva yemwedzi mishoma). Zviratidzo izvi zvinobata pakati pe55 kusvika 96% yevarwere vanobatwa nechirwere ichi. Zvave zvichiratidzwa kuti izvi zviratidzo zvekliniki zvinowanzokura zviri kure kubva kune mbabvu duku uye zvishoma nezvishoma zvinopararira mumuviri wose. Kune vashoma vevarwere, kurwadziwa kwemhasuru uku kunotungamirira kumatambudziko ekushanda. Mukuwedzera, kurwadziwa mumuzongoza kunowanzozivikanwa. Marwadzo aya anowanzonzwika pakarepo munhu paanomuka uye anosimbiswa panguva yekurovedza muviri uye mabasa ezuva nezuva;

- kusingaperi kuneta, kunobata pakati pe36 ne100% yevarwere. Uku kuneta kwakanyanya kunowanzokonzera kuderedzwa kwemabasa ezuva nezuva emunhu, zvose mupfungwa uye mumuviri;

-kukanganisa kwekuziva, mhedzisiro yakaregeredzwa kwenguva refu muchirwere. Izvi zvinoratidzira zvinoguma nekuora mwoyo, kuderera kwekuziva uye kuita kwenjere, kusagadzikana kwekutarisa, nezvimwe.

Zvimwe zviratidzo zvehutano zvinogonawo kusanganiswa nechirwere. Izvi zvinosanganisira zviratidzo zvepfungwa, kunyanya kusagadzikana kwemafungiro.

Dyspnea (kuoma kufema) uye kutemwa nemusoro zvakataurwawo mune vamwe varwere.

Kwakabva chirwere ndiko kuvapo kwealuminium hydroxides mumajekiseni anobaiwa muvarwere nenzira ye intramuscular.

Macrophage myofasciitis inobata varume nevakadzi, vanhu vakuru nevana, vasina mamiriro chaiwo ari pasi, kutevera jekiseni. Vakuru vanowanzobatwa mushure mekudzivirira mu deltoid, nepo vana vanobatwa mushure mejekiseni mu quadriceps.

Majekiseni anonyanya kukanganiswa nekuvapo kwealuminium munyu seadjuvant ndeaya:

1. mushonga wehepatitis B: 84%;

2. jekiseni rejenasi: 58%;

3. jekiseni rinorwisa hepatitis A: 19%.

Mukuwedzera, zvakaratidzwa kuti kuvapo kwealuminium salts mumuviri kunopfuurira. Kana kuti kuzadzikiswa kwemhasuru yebiopsy kunogona kupupurira kuvepo kwemakomponi aya ane mavambo ekudzivirira kubva makore akati wandei. (3)

Zvinogona kuita sekuti kune predispositions mune vamwe vanhu, vasingavabvumire kubvisa nemazvo maaruminiyamu emunyu anowanikwa mumajekiseni uye mune iyi pfungwa, vaone vachiungana mumhasuru tishu.

Izvo zvinokonzerwa nenjodzi yega yega yekukura kwechirwere hazvina kuratidzwa zvakajeka.

Kubatana pakati pezviratidzo zvehurongwa uye kukura kwechirwere kwakaratidzwa mune chikamu chidiki chezviitiko zve macrophage myofasciitis.

Mukuwedzera, genetic predispositions yakafungidzirwa, kunyanya muzviitiko zvakadzokororwa zvechirwere mukati mehama imwechete. Imwe tsvagiridzo yesainzi yakaratidza kuti imwe genetic nhaka inogona kuve nemhedzisiro pakuramba kwealuminium munyu mumasumbu. Iyo pathology inoratidzwa nekuwedzera kwekutenderera CCL2 / MCP-1, cytokine inobatanidzwa mukupinda kwenanoparticles muuropi. Kuchinja kwemajini mumajini anokodha iyi molecule inogona kuve imwe njodzi yekuwedzera chirwere.

Kuongororwa kwechirwere kunoitwa maererano nemhando dzakasiyana-siyana kana zvishoma zvinooneka zviratidzo zvekliniki. Chokwadi, yekutanga ine chekuita nekuvapo kwealuminium munyu, kubva mujekiseni rekudzivirira, mune tsandanyama tishu.

Mukuwedzera, kuvapo kwe myalgia (kurwadziwa kwetsandanyama) mu deltoid inobatanidza nekuzivikanwa kwealuminium hydroxides mukati menyama iyi, uye uchapupu hwekukura kwechirwere muvanhu vakuru.

Kutemerwa kwezviratidzo zvekiriniki (kurwadziwa kwetsandanyama kusingaperi, kuneta kusingaperi uye kusagadzikana kwekuziva) kunoitawo kuti zvikwanise kumisa kana kusaziva kwechirwere.

Kuongororwa kwakanaka kwechirwere kunosanganisira kuonekwa kwezvironda mu deltoid macrophages kuvanhu vakuru uye mu quadriceps muvana.

Mu 1/3 yezviitiko, kuwedzera kwehuwandu hwe plasma creatine kinase hunhu hwehutachiona. Nekudaro, iyi isingaite yakakwira cytokine nhanho inogona kunge yakabatana kune zvimwe zvirwere zvekuzvimba kana immune system. Mupfungwa iyi, ongororo dzekuwedzera dzekubvisa fungidziro yechimwe chikonzero dzinofanirwa kuitwa.

Iyo electrodiagnosis, MRI (Magnetic Resonance Imaging) yetsandanyama kazhinji inoita kuti zvibvire kubvumidza kana kusatendera maonero ekutanga.