Serum protein electrophoresis ongororo yakaitwa kubva mukuongororwa ropa iyo inobvumira kuongororwa uye kutarisa kwezvirwere zvakawanda senge monoclonal immunoglobulin, hypergammaglobulinemia uye zvakanyanya kashoma hypogammaglobulinemia.

Serum protein electrophoresis (EPS) ongororo yebhaibheri yezvehutano. Chinangwa chayo ndechekuparadzanisa mapuroteni aripo muchikamu chemvura cheropa (serum). "Mapuroteni aya anonyanya kuita basa mukutakura mamorekuru akawanda (mahomoni, lipids, zvinodhaka, nezvimwewo), uye anobatanidzwawo mukuita coagulation, kusadzivirirwa kwemuviri uye kuchengetedza BP. Kupatsanurwa uku kuchaita kuti zvikwanise kuziva nekuzviverengera ”, anodaro Dr Sophie Lyon, chiremba webiology.

Kuongorora kweprotein

Mushure mekuongororwa kweropa, mapuroteni anoongororwa nekutama mumunda wemagetsi. "Vanobva vaparadzana zvinoenderana nechaji yemagetsi uye huremu hwavo hwemamolekyulu, izvo zvinoita kuti vazive uye kuona zvinokanganisa." EPS ichabvumira kupatsanurwa kwezvikamu zvitanhatu zveprotein, mukuderera kwekurongeka kwekumhanya kwavo kwekufamba: albumin (inova iyo huru serum protein, pakuvapo kwe60%), alpha 1-globulins, alpha 2-globulins, Beta 1 globulin, Beta 2 globulin uye gammaglobulins. "Electrophoresis inoita kuti zvikwanise kuongorora mamwe ma pathologies ane chekuita nekusashanda zvakanaka kwechiropa kana itsvo, kuchinjwa kwedziviriro yekudzivirira, kune zviratidzo zvekuzvimba kana kune mamwe magomarara".

Mamiriro ekugadzirisa EPS akatsanangurwa neHaute Autorité de Santé (HAS) munaJanuary 2017. Chikonzero chikuru nei EPS inoitwa ndeyekutsvaga monoclonal immunoglobulin (monoclonal gammopathy, kana dysglobulinemia). Izvi zvinofamba nguva zhinji munzvimbo yegamma globulins uye dzimwe nguva munzvimbo yebeta-globulins kana kunyange alpha2-globulins.

Ndeipi nguva yekuita PSE?

Iwe unofanirwa kuita EPS kana iwe uri pamberi pe:

• Nhamba yepamusoro yeprotein inotenderera;
• Kuwedzera kusingatsananguriki muhuwandu hwekutsvaira (VS);
• Zvirwere zvinodzokororwa, kunyanya bhakitiriya (tsvaga kuperevedza kwekudzivirira muviri kunokonzera hypogammaglobulinemia);
• Clinical kana biological zviratidzo (hypercalcemia, somuenzaniso) zvichiratidza kuitika kwe myeloma kana chirwere cheropa;
• Kufungidzira kwechirwere chechirwere;
• Zvichida cirrhosis;
• Chero kuongorora kwe osteoporosis.

Zvichienderana neprotein, iwo mareferensi maitiro anofanira kunge ari pakati:

• Albumin: 55 uye 65% kana 36 uye 50 g / L.
• Alpha1 - globulins: 1 uye 4% kureva 1 uye 5 g / L
• .Alpha 2 – globulins: 6 ne10% kana 4 uye 8 g/l
• .Beta – maglobulins: 8 ne14% kana 5 uye 12 g/L.
• Gamma - globulins: 12 uye 20% kana 8 uye 16 g / L.
  

Electrophoresis ichabva yaona mapoka ekuwedzera kana kuderera mapuroteni muserum. “Protein yega yega yeropa ichaita mabhandi ehupamhi nekusimba kwakasiyana zvichienderana nehuwandu hwawo. Imwe neimwe hunhu "profile" inogona kududzirwa nachiremba ". Anogona, kana zvichidiwa, kunyora bvunzo dzekuwedzera.

Anomalies akaonekwa neEPS

Pakati peanomalies inowanikwa:

• Kuderera kwehuwandu hwealbumin (hypoalbuminemia), iyo inogona kukonzerwa nekushaya zvokudya zvinovaka muviri, kusashanda kwechiropa, chirwere chisingaperi, myeloma kana kunyange kuwandisa kwemvura (hemodilution).
• Hyper-alpha2-globulinemia uye kuderera kwealbumin kwakafanana nemamiriro ekuputika. Kusanganiswa kwezvikamu zvebeta negamma zvinoratidza cirrhosis.
• Kuderera kwegamma globulins (hypogammaglobulinemia) kunoonekwa kana paine kusashanda zvakanaka kwesimba rekudzivirira muviri. Kune rimwe divi, chiyero chinowedzera (hypergammaglobulinemia) mumamiriro e myeloma, monoclonal gammopathies uye autoimmune zvirwere (lupus, rheumatoid arthritis).
• Kuwedzera kwebeta globulins kunogona kureva kuvapo kwekushayikwa kwesimbi, hypothyroidism kana kuvharika kwebiliary.

Maererano neHAS, zvinokurudzirwa kutumira murwere kune mamwe mazano:

• Kana chirwere chemurwere chinoratidza hematologic malignancy (kurwadziwa kwepfupa, kuora kwemamiriro ezvinhu, lymphadenopathy, tumor syndrome);
• kana chiitiko chebiological abnormality (anemia, hypercalcemia, renal kukundikana) kana kufungidzira (maronda emapfupa) zvichiratidza kukanganisa kwenhengo;
• kana pasina zviratidzo zvakadaro, murwere uyo ane imwe yeongororo yekutanga isina kujairika, kana ane serum monoclonal immunoglobulin inonzi IgG? 15 g / L, IgA kana IgM? 10 g / L;
• kana murwere ari pasi pemakore makumi matanhatu.

Kurapa kweanomaly ye electrophoresis ndiko kweiyo pathology iyo inoratidzira.

“Semuenzaniso, kana paine hyperprotidemia yakazara nekuda kwekushaya mvura mumuviri, kurapwa kunenge kuri kudzorera mvura. Kana pane kuwedzera kwealpha globulins nekuda kwechirwere chechirwere, kurapwa kuchava kwechikonzero chekuputika. Muzviitiko zvese, ndiye chiremba uyo, achishandisa bvunzo iyi pamwe chete nedzimwe bvunzo dzekuwedzera (test yeropa, radiological test, zvichingodaro), achaita kuongororwa panguva yekubvunzurudza uye anozonyora kurapwa kwakagadziriswa kune pathology. kuwanikwa”.