Acanthosis nigricans (AN) chirwere cheganda chinoonekwa nerima, nzvimbo dzakakora dzeganda chaikonzeresa, kunyanya mumitsipa nemuhapwa. Iyi dermatosis inowanzova isina kunaka uye yakabatana nekufutisa, asi inogona zvakare kuve chiratidzo chechirwere chepasi chakadai sebundu rakashata.

Kuonekwa kwenzvimbo dzakasviba, dzakakora, dzakaoma uye dzakaoma, asi dzisingarwadzi, nzvimbo dzeganda hunhu hweAcanthosis nigricans. Muvara wavo unobva ku hyperpigmentation (yakawedzera melanin) uye kukora kubva ku hyperkeratosis (yakawedzera keratinization). Kukura-kufanana newarts kunogona kukura. Aya mavara anogona kuoneka pamativi ese emuviri, asi anonyanya kukanganisa mapete eganda, pamwero wemutsipa, armpits, groin uye genito-anal parts. Vanoonekwa zvishoma nezvishoma pamabvi, magokora, mazamu uye guvhu. Kuongororwa chaiko kunofanirwa kubvisa fungidziro yechirwere cheAddison [[+ link]] chinokonzeresa mabasa akafanana.

Vatsvakurudzi vanofungidzira kuti acanthosis nigricans maitiro ekudzivirira kweganda kune yakawandisa insulin, hormone inogadzirwa nepancreas inogadzirisa shuga yeropa. Uku kushorwa kwe insulini kunogona kuve kwakabatana nezvinetso zvakasiyana, kusanganisira kufutisa uye Type 2 chirwere cheshuga. Muchimiro chayo chinyoro, chinonyanya kuzivikanwa uye chinozivikanwa se pseudoacanthosis nigricans, izvi zviratidzo zveganda zvine chokuita nekufutisa uye zvinogadziriswa nekuderedza uremu. Mishonga inogona zvakare kuve iyo honzeri yezvimwe zviitiko, senge mahormone ekukura kana mamwe emuromo ekudzivirira kubata pamuviri.

Acanthosis nigricans inogona zvakare kuve chiratidzo chekunze uye chinooneka chepasi, chinyararire kusagadzikana. Ichi chimiro chakashata chine rombo rakanaka kuti hachiwanzoitiki nekuti chirwere chinokonzera kazhinji chinoshanduka kuva bundu rinotyisa: rinoonekwa mu1 mu6 varwere vane kenza, kazhinji inokanganisa gastrointestinal system kana genitourinary system. -urinary. Ivhareji yehupenyu hwehupenyu hwemurwere ane hutsinye AN inoderedzwa kusvika kumakore mashomanana. (000)

Varume nevakadzi vane hanya zvakaenzana uye acanthosis nigricans inogona kuoneka pazera ripi neripi, asi zvikuru kana munhu mukuru. Ziva kuti vanhu vane ganda dema vanowanzo batwa, saka kuwanda kweNA kuri 1-5% pakati pevachena uye 13% pakati pevatema. (1) Uku kuratidzwa kweganda kunoonekwa munenge hafu yevakuru vane kufutisa kwakanyanya.

Chirwere hachipararire. Kune zviitiko zvemhuri zveAN, ine autosomal dominant transmission (zvichikonzera kuti munhu abatwa ane 50% yengozi yekutapurira chirwere ichi kuvana vavo, vasikana nevakomana).

Kurapa kwe AN nyoro kunosanganisira kudzikisira mwero we insulin muropa nekudya kwakakodzera, kunyanya sezvo AN ichigona kuva chiratidzo cheyambiro yechirwere cheshuga. Chero zvazvingaitika, zvinodikanwa kubvunza dermatologist muchiitiko chekuonekwa kwenzvimbo ine rima uye gobvu ganda. Kana AN ichionekwa mumunhu asina kuwandisa, ongororo dzakadzama dzinofanirwa kuitwa kuti pave nechokwadi chekuti haina chekuita nekuvapo kwebundu.