Inotsanangurwa nekuvapo kwekunyanyisa acidity muropa, acidosis ndiyo mhedzisiro yeakasiyana metabolic kusagadzikana uye zvirwere umo acidity yakawandisa inogadzirwa. Dzimwe nguva injodzi yakakosha. Kutungamirirwa kwaro kunobva pakurapa chikonzero. 

Kuvapo kwe metabolic acidosis mumuviri kwakabatana nekuwedzera kwekugadzirwa kana kudyiwa kwemaasidhi uye / kana kudzikira kwekubuda kweasidhi. Izvo zvakare dzimwe nguva mhedzisiro yekurasikirwa negwara rekudya kana itsvo dzebicarbonates (HCO3-) dzinowanzo dzivirira kuvepo kwakanyanya kweasidhi muropa uye kutora chikamu muiyo acid-base chiyero.

Kazhinji, plasma (chikamu cheropa chisina masero matsvuku eropa, masero machena eropa uye maplatelet) imvura isina kwayakarerekera yemagetsi, ndiko kuti, ine yakawanda yakaipa ionic charges seyakanaka (HCOE-, H +, Na +, K +, CL-…). Ndipo apo machaji akanaka awanda muhuwandu ndipo panoitika metabolic acidosis.

Pane zvikonzero zvakawanda zve metabolic acidosis. Metabolic acidosis hachisi chirwere pachayo, asi chimiro chebhayoloji chekusaenzana kweropa pakati peasidhi nemabicarbonates. Kusaenzana uku mhedzisiro yezvizhinji zvinogona kuitika.

Kuvapo kwelactic acid yakawandisa nekuunganidza muropa

Iyi organic metabolic acidosis inokonzerwa ne: 

• mamiriro ekuvhunduka kwemuviri; 
• kukundikana kwechiropa (chiropa hachichaiti mabasa ekuchenesa ropa);
• chirwere cheropa chakadai seacute leukemia kana lymphoma (kenza ye lymph nodes);
• chirwere cheitsvo chisingaperi (itsvo hadzichabvisi asidi yakawandisa kubva muropa); 
• chepfu yezvokudya (methanol, salicylates, ethylene glycol, nezvimwewo);
• ketoacidosis (chirwere cheshuga kana insulin yapera).

Kuvapo kwelactic acid yakawandisa muropa nekuderedza kubviswa kwayo

Iyi mineral metabolic acidosis inobva:

• chakakomba itsvo kutadza;
• kuwandisa kweNaCl chloride infusion (munyu);
• kurasikirwa kwebicarbonate kubva muitsvo;
• kurasikirwa kwebicarbonate kubva mudumbu rekudya (manyoka);
• adrenal insufficiency.

Metabolic acidosis inogonawo kuitika mukutadza kufema kwakanyanya umo muviri usingachakwanise kubvisa kabhoni dhaikisai kuburikidza nemapapu, izvo zvinokonzeresa acidification yeplasma yeropa. Iyo acidosis inobva yanzi "kufema".

Kana muviri acid-base balance inogumburwa pasinei nechikonzero, zviratidzo zvakasiyana-siyana zvinogona kuratidzwa. Kana kusaenzana uku kuri pakati nepakati, hapazovi nezviratidzo kunze kwezvinokonzera (manyoka, kusagadzikana kunobatanidza nechirwere cheshuga chisina kukwana, nezvimwewo). Asi kusaenzana kunowedzerwa (pH <7,10), zvinotevera zviratidzo zvinogona kuitika:

• nausea;
• kurutsa;
• kunzwa kusanzwa zvakanaka;
• kuwedzera kwekufema (polypnea mukuedza kubvisa yakawandisa metabolic acidity);
• kuderera kweropa (hypotension) kana kunyange kuvhunduka kwemoyo nemwoyo arrhythmias uye coma.

Kana iyi acidosis iripo nenzira isingaperi (isingaperi kutadza kufema…), inogona kukonzera munguva yepakati kurasikirwa kwecalcium kubva mumapfupa (osteoporosis, rickets).

Kunze kwekutsvaga kwechikonzero chechikonzero nekuongorora kwekuwedzera, kuongororwa ropa pamwero wetsinga dzinoyera magasi eropa uye serum electrolytes ichaita kuti zvibvirire kuratidza mhedzisiro yebiological ye metabolic acidosis.

Izvo zvinokonzeresa metabolic acidosis zvichafungidzirwa nenhoroondo yekurapa (chirwere cheshuga, kufema, renal kana hepatic insufficiency ...) asiwo nekuongorora kwebiological kuongorora mazinga eshuga yeropa, hepatic uye renal kushanda, sodium neropa chlorine, kana chigadzirwa chine muchetura muropa. ropa (methanol, salicylate, ethylene glycol).

Kurapa kwe metabolic acidosis ndiko kutanga kwezvose izvo zvakakonzera (kusagadzikana kwechirwere cheshuga, manyoka, hepatic, renal kana kutadza kufema, nezvimwewo). Asi munjodzi kana iyo metabolic acidosis yakanyanya, dzimwe nguva zvinodikanwa kuita infusion yesodium bicarbonate kuderedza acidity yeplasma yeropa.

Muchiitiko chekutadza kwakanyanya kwerenal kana chepfu, hemodialysis (kusefa chepfu kubva muropa) ichachenesa ropa uye kutsiva basa reitsvo.

Pakupedzisira, mukutarisana nepakati chisingaperi acidosis, kudya kunokurudzirwa kudzoreredza acid-base chiyero cheropa nemazano akati wandei:

• sarudza chikafu chine alkaline (kurapa ndimu, tii yeginger, mhodzi dzenhanga, nezvimwewo);
• wana oxygen nekudzidzira mutambo wenguva dzose mumhepo yakashama;
• tora zvokudya zvinowedzera zvinokurudzira alkalization yeropa.