Agranulocytosis is abnormality yeropa inoratidzwa nekunyangarika kwechikamu chidiki cheleukocytes: neutrophilic granulocytes. Tichifunga nezvekukosha kwavo mukudzivirira muviri, kunyangarika kwavo kunoda kurapwa nekukurumidza.

Agranulocytosis izwi rezvokurapa rinoshandiswa kureva kusarongeka kweropa. Inofanana nekunyangarika kunenge kunyangarika kweropa neutrophil granulocytes, yaimbozivikanwa seropa neutrophils.

Izvi zvikamu zveropa chikamu cheleukocytes (masero machena eropa), masero eropa anobatanidzwa mukudzivirira muviri. Iyi subclass inomiririrawo ruzhinji rweleukocytes iripo muropa. Muropa, neutrophil granulocytes inoita basa rakakosha nekuti ibasa redziviriro kubva kune dzimwe nyika uye masero ane hutachiona. Vanokwanisa kuita phagocyte zvidimbu izvi, kureva kuzvitora kuti zviparadze.

Agranulocytosis is abnormality yeropa inogona kuzivikanwa nea hemogram, inonziwo Blood Count uye Formula (NFS). Muedzo uyu unopa ruzivo rwakawanda pamusoro pemasero eropa. Kuwanda kweropa kunoita kuti zvikwanise kunyanya kuverenga zvinhu zvakasiyana-siyana zveropa, izvo neutrophil granulocytes chikamu.

Munguva ye'neutrophil analysis, kusagadzikana kunoonekwa kana kuwanda kwemasero aya kuri pasi pe1700 / mm3, kana 1,7 g / L muropa. Kana chiyero che neutrophilic granulocytes chakanyanya kuderera, tinotaura nezve a neutropenia.

Agranulocytosis imhando yakakomba yeutropenia. Iyo inoratidzirwa neiyo yakaderera nhanho yeutrophilic granulocytes, isingasviki 500 / mm3, kana 0,5 g / L.

Muzviitiko zvakawanda, agranulocytosis iropa risina kujairika rinoitika mushure mekutora mamwe marapirwo emishonga. Zvichienderana nekwakabva uye hunhu hweanomaly, pane kazhinji marudzi maviri emushonga agranulocytosis:

• acute drug-induced agranulocytosis, kukurudzirwa kweiyo kunokonzerwa nekusarudzwa kwehutu hwemishonga, iyo inobata chete granulocyte line;
• zvinodhaka-induced agranulocytosis mumamiriro ezvinhu eaplastic anemia, kukura kunokonzerwa nekusagadzikana kwemapfupa emapfupa, ayo anoratidzwa nekuderera kwemasero akawanda eropa.

Muchirevo cheaplastic anemia, zvinokwanisikawo kusiyanisa akati wandei marudzi eagranulocytosis. Zvechokwadi, chirwere cheropa ichi chinoratidzwa nekukanganiswa mukugadzirwa kwemasero eropa mumwongo wemapfupa chinogona kuva nemavambo akawanda. Aplastic anemia inogona kutariswa se:

• post-chemotherapy aplastic anemia apo kutevera chemotherapy kurapwa;
• netsaona aplastic anemia kana zvichikonzerwa nemimwe mishonga.

Nepo zvinodhaka-induced agranulocytosis inomiririra pakati pe64 ne83% yezviitiko, izvi zvisiri izvo zvinogona kunge zvine zvimwe zvikonzero. Kubva kwebhakitiriya, hutachiona kana hutachiona, hutachiona huri padanho repamusoro hunogona kunyanya kukonzera kupera kwe neutrophilic granulocytes.

Tichifunga nezve basa re neutrophilic granuclocytes mu immune system, agranulocytosis inofumura chipenyu kune njodzi huru yehutachiona. Neutrophils haasisiri akawanda zvakakwana kupikisa kukura kwemamwe utachiona, izvo zvinogona kutungamirira kune septicemia, kana sepsis, utachiona huzhinji kana kuzvimba kwemuviri.

Zviratidzo zveagranulocytosis ndezviya zvehutachiona. Inogona kuzviratidza nezviratidzo zvinotapukira munzvimbo dzinoverengeka dzemuviri kusanganisira digestive system, iyo ENT sphere, pulmonary system kana kunyange ganda.

Acute drug-induced agranulocytosis inoonekwa kamwe kamwe uye inoratidzwa nekubuda kwefivha yakanyanya (kupfuura 38,5 ° C) ichiperekedzwa nekutonhora. Mumapfupa aplasia, kukura kweagranulocytosis kunogona kuitika zvishoma nezvishoma.

Agranulocytosis is abnormality yeropa inoda kurapwa nekukurumidza kudzivirira matambudziko. Kunyange zvazvo kurapwa kuchisiyana zvichienderana nekwakabva agranulocytosis, hutungamiri hwayo hunowanzoenderana ne:

• kuzviparadzanisa muchipatara kudzivirira murwere;
• kutanga kwemishonga inorwisa mabhakitiriya kurapa zvirwere;
• kushandiswa kwegranulocyte kukura zvinhu kukurudzira kugadzirwa kwe neutrophilic granulocytes.