Alzheimer's - izvi zvinogona kunge zviri zviratidzo zvekutanga nguva refu isati yatanga chirwere. Chidzidzo chitsva

Kwete matambudziko endangariro chete. Zviratidzo zvekutanga zvechirwere cheAlzheimer zvinogona kuoneka kare kare. “Migumisiro yezvinogamuchirika muuropi zvine chokuita nokukurudzira uye manzwiro zvinotungamirira kurufu rwetsinga dzetsinga uye kusagadzikana kwechimiro chesynaptic muvanhu vane hosha yeAlzheimer,” anoshuma kudaro masayendisiti anobva kuIndiana University School of Medicine mumagazini inonzi Molecular Psychiatry.

1. Kunyange zvazvo chirwere cheAlzheimer chakabatana nevakwegura, masayendisiti akawanda ari kuratidza kuti zviratidzo zvayo zvekutanga zvinogona kuonekwa kare kusvika makumi mana.
2. Zvino zvakawanwa kuti kare pamberi pezvinetso zvendangariro, varwere vanowana zviratidzo zvakadai sokusakendenga uye kushatirwa.
3. Rumwe ruzivo runogona kuwanikwa pane iyo Onet peji rekutanga

Chirwere cheAlzheimer - Ndedzipi Nzvimbo dzeHuropi Zvinokanganisa?

Mukutsvaga kwavo, masayendisiti akatarisa pane nucleus accumbens (imwe yebasal ganglia) iri mu striatum. Iyi nharaunda chikamu chemubairo system uye inokanganisa kukurudzira.

-Pakave nekufarira kushoma mune nucleus accumbens sechimiro chakabatana nechirwere cheAlzheimer. Ivo vanonyanya kudzidzwa kuti vanzwisise zvinokurudzira uye zvemanzwiro maitiro. Zvidzidzo zvakapfuura, zvisinei, zvakaona kuti huwandu hweiyo nucleus accumbens, pamwe neiyo cortical nzvimbo uye hippocampus, yakaderedzwa muvarwere veAlzheimer, vanyori vanocherekedza.

Kunyange kusati kwatanga kuderera kwekuziva kusati kwaonekwa, vanhu vazhinji vane chirwere cheAlzheimer vanoona kushanduka kwemafungiro, uye kazhinji zviratidzo zvekuora mwoyo.

Iwe unoda kuziva chikonzero chekuora mwoyo kwako here? Ita Mood Swings - pasuru yebvunzo inoongorora zvikonzero zvemalaise inowanikwa mune vhezheni ine sampling yeropa repamba, iyo inofambisa zvakanyanya kuongororwa, kunyanya muvanhu vakura vane dambudziko rekusvika kunzvimbo yekurapa.

Kusava nehanya uye kutsamwa - zviratidzo zvekutanga zveAlzheimer's?

- Nekudaro, zviratidzo zveurouropsychiatric, sekusava nehanya uye kutsamwa, zvinoitika pamberi pematambudziko ekurangarira, saka zvakaoma kupindura nenguva.. Nokudaro, tinofanira kunzwisisa kuti nei zviratidzo izvi zvichionekwa uye kuti zvakabatana sei nekukanganisa kwekuziva, inosimbisa munyori wekudzidza, Dr. Yao-Ying Ma.

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Nekufunda modhi yechirwere cheAlzheimer, masayendisiti akacherechedza CP-AMPA (calcium ion permeable) receptors munyucleus accumbens inobatanidzwa mukukurumidza kutapurirana kwesynaptic. Aya ma receptors, kazhinji asipo muchikamu ichi cheuropi, anobvumira calcium ions kupinda mumasero etsinga. Yakawandisa karusiyamu, zvakare, inotungamira kune kusagadzikana kweiyo synaptic mashandiro uye inokonzera akati wandei intracellular shanduko inogona kukonzera kufa neuronal.

Uku kurasikirwa kwekubatanidza synaptic kunokonzera matambudziko ekukurudzira. Nekudaro, kunanga nekuvhara CP-AMPA receptors kunogona kunonoka kukura kwechirwere cheAlzheimer.

- Kana tikakwanisa kunonoka kuchinja kwepathological mune imwe yenzvimbo dzakakanganiswa, semuenzaniso mu nucleus accumbens, inogona kuita kuti kunonoka kwezvipembenene kune dzimwe nzvimbo pamwe chete - anodaro Dr. Ma.