La bilirubin ndiwo Nguruve kwete kunyungudika mumvura yero ruvara, zvichibva mukuora kwehemoglobin. Ndiyo dhayi huru ye kunyange. Inogadzirwa mumasero e rate uye mwongo webhonzo, uye wobva watakurwa nemuropa nealbumin kuenda kuchiropa. Kana yavepo muchiropa, inosanganiswa negluconic acid uye inonyungudika mumvura. Mumatumbu, conjugated bilirubin inopa chituru ruvara rwebrown.

Chiremba acharaira kuongororwa ropa kwebilirubin kana achifungidzira, semuenzaniso:

• hepatobiliary disorders: mamiriro ezvinhu anokanganisa chiropa (Hepatitis ndiyo inonyanya kuzivikanwa) uye / kana bile ducts
• hemolytic syndromes (inozivikanwa nekuparadzwa kusingaenzaniswi kwemasero matsvuku eropa)
• kana jaundice yomucheche, inonziwo jaundice yomucheche

Kuongororwa kwebilirubin, kuongororwa ropa kunofanira kuitwa, iyo inosanganisira kuongororwa kweropa re venous. Zvinokurudzirwa kuti usadye kana kunwa zvishoma maawa mana asati aongororwa ropa. Chiremba anogona zvakare kukumbira murwere kuti arege kutora mimwe mishonga inogona kukanganisa mhedzisiro yekuongororwa kwebilirubin.

Huwandu hwebilirubin muropa hunowanzo pakati pe0,3 ne1,9 mg/dl (milligrams per deciliter). Huwandu hweiyo conjugated bilirubin (inonziwo yakananga bilirubin) inowanzova pakati pe0 ne0,3 mg/dl. 

Ziva kuti izvo zvinonzi zvakajairika kukosha kwebilirubin muropa zvinogona kusiyana zvichienderana nerabhoritari iri kuita ongororo.

Chiremba chete ndiye anogona kududzira mhedzisiro uye kukupa kuongororwa.

Kana iyo bilirubin level yakakwira, inonzihyperbilirubinémie.

Inogona kuva:

• predominance yefomu yemahara (nekuwedzera kugadzirwa kana kushomeka kwekubatanidza):

— tsaona transfusionnels

- hemolytic anemias: chepfu, mushonga, parasitic hemolysis, nezvimwewo.

- Chirwere chaGilbert (genetic kusagadzikana kwebilirubin metabolism)

- jaundice yemwana achangoberekwa

- Criggler-Najjar syndrome (yakagara nhaka kusagadzikana kwebilirubin metabolism)

• predominance yeiyo conjugated fomu (conjugated bilirubin inoburitswa mukutenderera kana nzira yakajairika yekubuda yakavharwa):

- gallstone

- neoplasia (gomarara)

- pancreatitis

- chepfu hepatitis, doro hepatitis, viral hepatitis

- cirrhosis

Imwe inosiyanisa kunyanya "jaundice ine bilirubin yakasununguka", iyo inokonzerwa nekudarika kwekuparadzwa kwemasero matsvuku eropa (hemolysis) ye "jaundice ine conjugated bilirubin", asi ine chokuita nechirwere chebiliary kana hepatic.