Mukati
Chirwere cheCharcot
Chirwere cheCharcot, chinonziwo amyotrophic lateral sclerosis (ALS) chirwere chetsinga. Inosvika zvishoma nezvishoma neurons uye inotungamirira kukushaya simba kwetsandanyama kunoteverwa nekuoma mitezo. Hupenyu hwevarwere hunoramba huri hupfupi kwazvo. MuChirungu, inonziwo chirwere cheLou Gehrig, mukukudza mutambi webaseball ane mukurumbira anorwara nechirwere ichi. Zita rokuti "Charcot" rinobva kuFrench neurologist uyo akatsanangura chirwere.
Maneuron akabatwa nechirwere chaCharcot imotor neurons (kana mota neurons), ane basa rekutumira ruzivo uye mafambiro ekufamba kubva kuuropi kuenda kumamhasuru. Masero etsinga anoderera zvishoma nezvishoma obva afa. Tsandanyama dzekuzvidira hadzichadzorwi neuropi kana kukurudzirwa. Vasina kushanda, vanopedzisira vasisashande uye atrophy. Pakutanga kweizvi chirwere chetsinga chinopfuurira, munhu akabatwa anotambura nekurwadziwa kwemhasuru kana kushaya simba mumakumbo, maoko kana makumbo. Vamwe vane matambudziko ekutaura.
Kana tichida kuita mafambiro, meseji yemagetsi inopfuura nepamotor neuron yekutanga iyo inotanga kubva kuuropi ichienda kumusana wobva wakwereta neuron yechipiri kune tsandanyama ine chekuita nazvo. Ekutanga imotor neurons pakati kana kumusoro uye anowanikwa chaizvo mucerebral cortex. Yechipiri imotor neurons peripheral kana pasi, uye anowanikwa mumuzongoza. |
Kubudirira kwe upper motor neuron inonyanya kuratidzwa nekunonoka kwekufamba (bradykinesia), kuderedzwa kuwirirana uye dexterity uye kuoma kwemisumbu ne spasticity. Kubudirira kwe yakaderera injini neuron inozviratidza kunyanya nekushaya simba kwetsandanyama, makumbo uye atrophy yetsandanyama inotungamirira kukuoma mitezo.
Chirwere cheCharcot chinogona kuita kuti kumedza kuve kwakaoma uye kutadzisa vanhu kudya zvakanaka. Vanhu vanorwara vanogona kuzotambura nekushaya chikafu chinovaka muviri kana kutora nzira isiriyo (= tsaona ine chekuita nekumedzwa kwezvakaoma kana zvinwiwa kuburikidza nekufema). Sezvo chirwere ichi chichienderera mberi, chinogona kukanganisa mhasuru dzinodiwa kufema.
Mushure memakore matatu kusvika mashanu ekushanduka-shanduka, chirwere cheCharcot chinogona kukonzera kutadza kufema izvo zvinogona kutungamirira kurufu. Chirwere ichi, chinobata varume zvishoma kudarika vakadzi (3 kusvika 5) kazhinji chinotanga kumativi makumi matanhatu emakore (pakati pemakore makumi mana nemakumi manomwe). Zvikonzero zvayo hazvizivikanwi. Mune chimwe chezviitiko gumi chikonzero chemajini chinofungidzirwa. Kwakabva kutanga kwechirwere zvichida kunoenderana nezvinhu zvakasiyana-siyana, zvakatipoteredza uye genetic.
Hapana hapana kurapwa chirwere cheCharcot. Mushonga, riluzole, inononoka zvishoma kufambira mberi kwechirwere, kushanduka uku kushanduka zvikuru kubva kune mumwe munhu kuenda kune mumwe uye kunyange, mumurwere mumwe chete, kubva kune imwe nguva kuenda kune imwe. Mune dzimwe, chirwere, chisingakanganisi pfungwa (kuona, kubata, kunzwa, kunhuwa, kuravira), dzimwe nguva inogona kugadzikana. ALS inoda kunyatsotariswa. Kutarisira kunosanganisira kunyanya kubvisa zviratidzo zvechirwere.
Kuwanda kwechirwere ichi
Maererano nesangano rekutsvakurudza nezvechirwere cheCharcot, chiitiko chechirwere cheCharcot i1,5 zviitiko zvitsva pagore pavagari ve100. Pamwe padyo ne 1000 nyaya itsva pagore muFrance.
Kuongororwa kwechirwere cheCharcot
Kuongororwa kweALS kunobatsira kusiyanisa chirwere ichi kubva kune dzimwe zvirwere zvetsinga. Dzimwe nguva zvakaoma, kunyanya nokuti hapana mucherechedzo chaiwo wechirwere muropa uye nokuti pakutanga kwechirwere, zviratidzo zvekliniki hazvirevi kunyatsojeka. Chiremba wetsinga achatarisa kuoma mumhasuru kana cramps semuenzaniso.
Kuongororwa kunogona kusanganisira a electromyogram, kuongorora kunobvumira kuona maitiro emagetsi aripo mumasumbu, MRI yekuona uropi uye musana. Ropa uye weti bvunzo zvinogona zvakare kurairwa, kunyanya kutonga kunze kwezvimwe zvirwere zvinogona kunge zvine zviratidzo zvinowanzoitika kune ALS.
Kuchinja kwechirwere ichi
Chirwere cheCharcot saka chinotanga nekushaya simba kwemhasuru. Kazhinji kazhinji, maoko nemakumbo ndiwo anotanga kubatwa. Kozoita tsandanyama dzerurimi, dzemuromo, dzozoti dzekufema.
Zvikonzero zvechirwere cheCharcot
Sezvambotaurwa, zvikonzero pari zvino hazvizivikanwe mune zvingangosvika zvipfumbamwe kubva mugumi (9 kusvika 10% yenyaya inhaka). Nzira dzinoverengeka dzinogona kutsanangura kutaridzika kwechirwere dzakaongororwa: chirwere che autoimmune, kusaenzana kwemakemikari… Kwechinguva pasina kubudirira.