Le cortisol ndiwo steroid hormone yakagadzirwa kubva cholesterol uye yakavanzwa nemagland pamusoro peitsvo (the adrenal cortex) Kubuda kwaro kunobva kune imwe hormone, ACTH inogadzirwa nepituitary gland muuropi (ACTH ye adrenocorticotropin).

Cortisol inoita mabasa akati wandei mumuviri, kusanganisira:

• Iyo metabolism yemakabhohaidhiretsi, lipids uye mapuroteni: inobatsira kudzora shuga yeropa nekuwedzera glucose synthesis nechiropa (gluconeogenesis), asi zvakare inosimudzira kuburitswa kwelipids nemapuroteni mumatishu mazhinji.

• Iine anti-inflammatory reaction

• Kugadzirisa BP

• Kukura kwebhonzo

• Mhinduro yekushushikana: Cortisol inowanzonzi ihomoni yekushushikana. Basa rayo nderekubatsira muviri kurarama, nekuunganidza simba rinodiwa kudyisa tsandanyama, uropi asiwo moyo.

Ziva kuti mwero we cortisol unosiyana zvichienderana nenguva yemasikati nehusiku: yakakwirira mangwanani uye inoderera mukati mezuva rose kusvika padanho rayo rakaderera manheru.

Chiremba anoraira kuyedzwa kwechiyero checortisol muropa kuti atarise kukanganisa kune adrenal glands kana pituitary gland. Cortisol uye ACTH zvinowanzoyerwa panguva imwe chete.

Ongororo ine a kuongorora ropa, inoitwa mangwanani pakati pe7 am na9 am Apa ndipo apo cortisol mazinga akakwirira uye akanyanya kugadzikana. Vashandi vezvokurapa vanoongorora vanotora ropa retsinga, kazhinji kubva pakupetwa kwegokora.

Sezvo mazinga ecortisol achichinja zuva rese, bvunzo inogona kuitwa kakawanda kuti uwane mufananidzo wakajeka weavhareji yekugadzirwa kwecortisol.

Chiyero che cortisol chinogonawo kuyerwa muweti (chiyero cheurinary free cortisol, kunyanya inobatsira pakuona hypersecretion ye cortisol). Kuti uite izvi, weti inofanirwa kuunganidzwa mumudziyo wakapihwa chinangwa ichi kwemaawa makumi maviri nemana.

Tichakutsanangurira maitiro acho, ayo anowanzo sanganisira kuunganidza weti yese yezuva (nekuichengeta munzvimbo inotonhorera).

Usati waongororwa (ropa kana weti), zvinokurudzirwa kudzivirira chero mamiriro ezvinhu anoshungurudza kana kurovedza muviri. Chiremba anogonawo kukumbira kumisa mamwe marapirwo anogona kukanganisa kuyerwa kwecortisol (estrogen, androgens, nezvimwewo).

Muropa, kukosha kwakajairika kwecortisol yakaongororwa pakati pe7 am ne9 am iri pakati pe5 ne23 μg / dl (micrograms per deciliter).

Muweti, chiyero che cortisol chinowanzo kuwanikwa chiri pakati pe10 ne100 μg / 24h (micrograms pamaawa makumi maviri nemana).

Yakakwira cortisol mazinga anogona kuve chiratidzo che:

• Cushing's syndrome (hypertension, kufutisa, hyperglycemia, nezvimwewo)

• chirwere chisina kunaka kana chakaipa cheadrenal gland

• hutachiona hwakanyanya

• capsular stroke, myocardial infarction

• kana cirrhosis yechiropa, kana kudhakwa kwenguva refu

Pane zvinopesana, mwero wakaderera we cortisol unogona kufanana ne:

• adrenal kushomeka

• chirwere cheAddison

• kusashanda zvakanaka kwepituitary kana hypothalamus

• kana kuve mhedzisiro yenguva refu corticosteroid therapy

Chiremba chete ndiye achakwanisa kududzira zvawanikwa uye kukupa kuongororwa (yekuwedzera miedzo dzimwe nguva inodiwa).