Fecal elastase ienzyme inogadzirwa nepancreas inoita basa mukugaya. Chiyero chayo chinoita kuti zvikwanise kuongorora kushanda kwakakodzera kweiyo pancreas ine chekuita nekugaya.

Pancreas inhengo yemuviri wemunhu ine mabasa maviri:

• basa re endocrine re 10% yemasero: pancreas inobudisa insulini uye glucagon, mahomoni maviri ane mutoro wekugadzirisa chiyero cheshuga muropa. Insulin inoderedza shuga yeropa nepo glucagon ichiwedzera. Aya mahomoni maviri anobatsira kuchengetedza huwandu hweshuga yeropa. Kana pane dambudziko ne insulin secretion, tinotaura nezvechirwere cheshuga;
• basa re exocrine re90% yemasero: by acinar masero, pancreas inoburitsa pancreatic enzymes, mapuroteni ane basa chairo. Aya ma enzymes chikamu chepancreatic juices uye akakosha pakugaya kwakaringana kwechikafu. Kuburikidza nekusarura kweiyo Wirsung neSantorini migero, iyo pancreatic juices inosiya pancreas kuti iuye kuzosanganisa ne bile muura. Muchikamu chekudya, ma enzymes aya anotora chikamu mukugaya kwemafuta, mapuroteni uye makabhohaidhiretsi nekuaputsa kuita zvinhu zvakawanda, zviri nyore kutorwa nemuviri.

Fecal elastase imwe ye enzymes inogadzirwa nerwatata. Iyo inogadzirwa nenzira yakagadzikana uye inogara iripo, iyo inoita kuti ive yakanaka pancreatic chiratidzo. Chinangwa chefecal elastase assay ndechekuongorora kushanda kwakakodzera kweiyo exocrine basa repancreas. Chirevo chetauro ndeye 200 micrograms pagiramu rechigaro muvanhu vakuru nevana (kubva pamwedzi mumwe chete). Ukoshi uhwu hwakagadzikana uye hunosiyana zvishoma kubva kune rimwe zuva kuenda kune rimwe mumunhu mumwe chete kunze kwenyaya yemanyoka akanyanya anoderedza mwero wefecal elastase. Muchiitiko ichi, kuongorora kuchafanirwa kudzokororwa. Muyedzo uri nyore kuita, unobvumira kuti utsive kune mimwe miedzo yakaoma seyekudzidza steatorrhea.

Iyi bvunzo inoitwa kuti iongorore kushanda kweiyo exocrine basa repancreas. Inogona semuenzaniso kuitiswa muchiitiko chekufungira exocrine pancreatic insufficiency. Inogonawo kukumbirwa nachiremba kuti vaone zvikonzero zvedambudziko remanyoka risingaperi.

Kutemerwa kwefaecal elastase kunoitwa pane sampuli yechigaro. Murwere anogona kutora sample kumba kwake nezvinhu zvinopihwa nerabhoritari yekuongorora kurapwa. Anobva akurumidza kudonhedza sampuli murabhoritari kuti iongororwe. Muenzaniso unofanirwa kuchengetwa pa4 ° C (mufiriji). Ongororo yacho inofanira kuitwa mukati memaawa makumi mana nemasere ekuunganidza stool. Iyi sandwich-mhando ELISA bvunzo, yakanangana nevanhu elastase (elastase E48). Muedzo uyu unosanganisira kupatsanura puroteni pakati pemasoja maviri ekudzivirira chirwere, imwe neimwe ichiziva chidimbu cheprotein, nokudaro zvichiita kuti ikwanise kuiona nekuiverenga.

Kana murwere akawedzerwa ne enzyme replacement therapy, izvi hazvina kukanganisa pachiyero chefecal elastase. Sezvineiwo, zvimwe zvinhu zvinofanirwa kudziviswa svondo risati rasvika uye pazuva remuenzaniso:

• kugaya radiological kuongororwa;
• kugadzirira colonoscopy;
• laxatives;
• mapfekero emukati kana zvinodhaka zvinorwisa manyoka. Zvechokwadi, zvinhu izvi zvinogona kugadzirisa intestinal flora kana kukanganisa migumisiro yekuongorora.

Saizvozvowo, zvinokurudzirwa kudzivisa, kana zvichibvira, kuongorora uku panguva yekuora kwakanyanya. Kana izvi zvisingakwanisi, zvinofanira kutaurirwa kuitira kuti chiremba azvifungidzire paanenge achiongorora migumisiro.

Kunyanya kuderera kwefecal elastase (kunze kwekunge manyoka) kunoratidza kusakwana mubasa re exocrine ye pancreas. Kusangana pakati pe150 ne200 µg / g chiratidzo chepakati exocrine pancreatic insufficiency. Isu tinotaura nezve exocrine pancreatic insufficiency apo chiyero chefecal elastase chiri pasi pe15 μg / g.

Kubva ipapo, chiremba achada kuita kumwe kuongorora, bvunzo uye imaging kuti aone chikonzero chekusakwana uku. Pane zvakawanda zvinogoneka:

• chisingaperi chirwatata;
• kurwara kwepacreatitis;
• cystic fibrosis;
• chirwere cheshuga;
• celiac chirwere;
• Chirwere cheCrohn;
• Zollinger-Ellison syndrome;
• kuvhiyiwa kwepamusoro mudumbu;
• etc.