Hypogammaglobulonemia kuderera kwechiyero chegamma-globulins kana immunoglobulins, zvinhu zvine basa rakakosha mukudzivirira kwemuviri. Iyi biological anomaly inogona kukonzerwa nekutora mimwe mishonga kana kune akasiyana pathologies, mamwe acho anoda kukurumidza kuongororwa. 

Hypogammaglobulinemia inotsanangurwa negamma-globulin nhanho isingasviki 6 g/l paplasma protein electrophoresis (EPP). 

MaGamma globulins, anonziwo immunoglobulins, zvinhu zvinogadzirwa nemasero eropa. Vane basa rinokosha zvikuru mukudzivirira kwemuviri. Hypogammaglobumonemia inotungamira kune yakawedzera kana kushoma kuderera kwekudzivirira kwekudzivirira. Kashoma.

Ongororo inobvumira kutsunga kwegamma-globulins, pakati pezvimwe zvinhu, ndeye electrophoresis yemapuroteni eserum kana mapuroteni eplasma.Inoitwa kana paine kufungirwa kwezvimwe zvirwere kana kutevera mhedzisiro isina kujairika panguva yekuongororwa kwekutanga. 

Kuongororwa uku kunorongedzerwa kana paine kufungirwa kwehumoral immune deficiency muhupo hwezvirwere zvinodzokororwa, kunyanya zveENT uye bronchopulmonary sphere kana kuderera kwemamiriro ekunze, kana paine kufungirwa kwemultiple myeloma (zviratidzo: marwadzo emapfupa, anemia, zvirwere zvinowanzoitika…). 

Muedzo uyu unogona zvakare kushandiswa zvichitevera mhedzisiro isina kujairika inoratidza kuwedzera kana kudzikira kweserum protein, high urine protein, high blood calcium, kusaenzana kwehuwandu hwemasero matsvuku eropa kana masero machena eropa.

Iyo electrophoresis yeSerum mapuroteni ndiyo bvunzo inoita kuti zvikwanise kuyera gamma globulins. 

Iyi ongororo yebiology yemazuva ese (sample yeropa, kazhinji kubva kugokora) inobvumira maitiro ehuwandu hweakasiyana mapuroteni zvikamu zveserum (albumin, alpha1 uye alpha2 globulins, beta1 uye beta2 globulins, gamma globulin). 

Iyo electrophoresis ye serum mapuroteni kuongororwa kwakapusa kunoita kuti zvikwanise kuona uye kutora chikamu mukutarisisa kweakawanda pathologies: kuzvimba syndromes, mamwe cancers, physiological kana hutano kusagadzikana.

Inotungamira kune inodiwa yekuwedzera bvunzo (immunofixation uye / kana chaiyo assay yemapuroteni, haematological assessment, renal kana digestive kuongorora).

Kuwanikwa kwe hypogammaglobulonemia kunogona kunge kuri nekuda kwekutorwa kwemishonga (oral corticosteroid therapy, immunosuppressants, anti-epileptics, tumor chemotherapy, nezvimwewo) kana kune zvakasiyana-siyana zvirwere. 

Ongororo yekuwedzera inobvumira kuongororwa kuti kuitwe kana chikonzero chemushonga chikarambidzwa. 

Kuti uone pathologies inova yekukurumidzira yekuongorora (light chain myeloma, lymphoma, chronic myeloid leukemia), bvunzo nhatu dzinoitwa: kutsvaga tumor syndrome (lymphadenopathy, hepato-splenomegaly), kuongororwa kweproteinuria uye kuverenga kweropa.

Kana izvi zvechimbichimbi izvi zvave kubviswa zvimwe zvikonzero zve hypogammaglobulonemia zvinotaurwa: nephrotic syndrome, exudative enteropathies. Zvikonzero zve exudative enteropathies zvinogona kunge zvisingaperi zvinoputika bowel chirwere, celiac chirwere pamwe neakasimba digestive tumors kana mamwe lymphoid hemopathies senge lymphoma kana primary amyloidosis (LA, light chain amyloidosis ye immunoglobulins).

Kakawanda, hypogammaglobulonemia inogona kukonzerwa nekushaikwa kwehumoral immune system.

Kushaikwa kwezvokudya zvinovaka muviri zvakanyanya kana Cushing's syndrome inogonawo kukonzera hypogammaglobulonemia.

Ongororo yekuwedzera inobvumira kuongororwa kuti kuitwe (thoraco-abdominal-pelvic scanner, kuverenga kweropa, kuzvimba, albuminemia, 24-awa proteinuria, kuyerwa kwehuremu hwe immunoglobulins uye immunofixation yeropa)

Kurapa kunoenderana nechinokonzera. 

Inogona kumisa kurapa kwekudzivirira muvanhu vanotambura ne hypogammaglobulinemia: anti-pneumococcal vaccination uye mamwe majekiseni, antibiotic prophylaxis, kutsiva mune polyvalent immunoglobulins.