Mukati
Irregular agglutinins
Tsanangudzo yekuongororwa kweagglutinins isina kukwana
The agglutinines ndivo antibody, ndiko kuti, mamorekuru anogadzirwa ne immune system "kuona" vamiririri vekunze.
Izwi rekuti "irregular agglutinins" rinoreva masoja ekudzivirira chirwere anonangana nemamwe mamorekuru (maantigen) aripo pamusoro pemasero. Masero matsvuku.
Masoja ekudzivirira chirwere aya “haana kurongeka” nekuti haana kujairika, ane njodzi.
Zvamazvirokwazvo, ivo vari mungozi yokupandukira masero matsvuku eropa omurwere amene ndokuarwisa, neimwe nzira.
Kutsvaga kusinganzwisisiki agglutinins (RAI) naizvozvo kuongorora kwakakosha mumamiriro ezvinhu akawanda, kusanganisira pamuviri, kudzivisa rudzi urwu rwekunetseka.
Kuvapo kweaya abnormal antibodies kunowanzo kutsanangurwa nekuona kwekare kwe kuwedzerwa ropa kana na nhumbu, muvakadzi. Nokudaro, panguva yokuwedzerwa ropa kana kuti panguva yokuzvitakura, ropa “romutorwa” (iro romupi kana kuti romudumbu) rinosangana neropa romunhu wacho. Mukupindura, immune system inogadzira masoja ekudzivirira chirwere anonangana neaya ekunze masero matsvuku eropa. Panguva yekuratidzwa kwechipiri (kuwedzerwa kutsva kana pamuviri mutsva), masoja ekudzivirira chirwere aya anogona kuita zvakasimba uye kukonzera kuparadzwa kwemasero matsvuku eropa, izvo zvinogona kuva nemigumisiro yakakomba yekliniki (kuwedzerwa ropa, somuenzaniso).
Mumukadzi ane pamuviri, kuvapo kwerudzi urwu rwehutachiona hunogona kukonzera, mune dzimwe nguva, chirwere chakakomba chinonzi hemolytic chirwere chechecheche.
Irregular agglutinins inogonawo kukonzerwa ne autoimmunization (immune system dysfunction). Aya anobva angove ma-auto-antibodies, anonangana nemaantigen emurwere pachake.
Sei uchiita isina kujairika agglutinin assay?
RAI ine chinangwa chekuratidza kuvepo kwemasoja anorwisa masero matsvuku eropa.
Masoja ekudzivirira chirwere aya ndeemhando dzakati wandei (zvichienderana nemorekuru raanonanga).
Dzinogona kuva nengozi kana munhu awedzerwa ropa kana kuti ane pamuviri.
Iyo RAI saka inoitwa zvakarongeka:
- mumunhu chero upi zvake angangowedzerwa ropa
- mushure mekuisirwa ropa (sechikamu chehemovigilance monitoring)
- mumadzimai ose ane pamuviri
Panguva yekuzvitakura, RAI yakarongeka kanenge kaviri muvakadzi vasina nhoroondo yekuwedzerwa ropa (kusati kwapera kwe2.st mwedzi wepamuviri uye panguva ye8st uye/kana 9st mwedzi). Inowanzojairika (kanenge ka4) muRh negative vakadzi (inenge 15% yevanhu).
Ongororo iyi ine chinangwa chekudzivirira kuisirwa ropa kana tsaona ye fetal-maternal (yakanyanya anemia, hemorrhages, jaundice).
Semuenzaniso, njodzi dzakadaro dzinogona kuitika kana mukadzi ane rh negative (negative blood group) uye ane pamuviri we rh positive murume. Munguva yekutanga pamuviri, ropa remucheche (kana riri Rh +, zvakare), harina kusangana neraamai, saka hapana dambudziko. Ukuwo, panguva yekusununguka, ropa reviri rinosangana uye amai vanogadzira anti-Rhesus positive antibodies. Kusangana uku kunogonawo kuitika kana munhu abva pamuviri kana kubvisa pamuviri nokuzvidira.
Munguva yechipiri yepamuviri, ma antibodies aya anogona kukonzera kuparara (kana chibereko chiri Rh + zvakare), kana chirwere chehemolytic checheche achangoberekwa, kureva kuparadzwa kukuru kwemasero matsvuku eropa remwana. . Kudzivirira dambudziko iri, zvakakwana, panguva yekusununguka kwega kwega, kubaya amai jekiseni reanti Rhesus (kana kuti anti D) serum, iyo inoparadza mashoma masero matsvuku eropa emwana anenge apinda mukufamba kwaamai uye kudzivirira kubaiwa. .
Nzira yekuongororwa kweagglutinins isina kukwana uye migumisiro
Kuongorora kunoitwa nyore kuongorora ropa, murabhoritari yekuongorora kurapwa. Ropa remurwere rinosangana neakasiyana siyana evanopa (anomiririra kusiyana kwemaantigen ayo agglutinins anogona kuumbwa). Kana iyo agglutinins isingawanzoitiki, ichaita pamberi pemasero aya.
Ndezvipi zvigumisiro zvinotarisirwa nekutsvaga kweagglutinins isina kukwana?
Kuongororwa kunenge kusina kunaka kana kwakanaka, kuratidza kana kusavapo kweagglutinins isina kukwana muropa.
Kana kutariswa kuri kwakanaka, zvichave zvakakosha kuti uone chaizvo kuti ndeapi masoja ekudzivirira chirwere (kuitira kuziva kuti ndeapi mamorekuru aanogona kuita).
Muchiitiko chekuwedzerwa kunotevera, izvi zvinobvumira kusarudzwa kweropa rinoenderana nemurwere.
Panguva yekuzvitakura, kuvapo kweagglutinins isina kukwana haisi iyo ine ngozi. Kazhinji, masoja ekudzivirira chirwere aya haana njodzi kumwana (haanyanyi “hasha” kana kuti "fetus" inogona kuenderana).
Zvisinei, kukura kwakakodzera kwe fetus kuchadzorwa zvakasimba.
Iyo inonzi "anti-D" agglutinins (anti-RH1, asiwo anti-RH4 uye anti-KEL1), kunyanya, inoda kuongororwa nguva dzose uye dosing (kamwe kamwe pamwedzi kusvika pakusununguka uye kunyange mazuva ose masere kusvika gumi nemashanu mukati. yechitatu trimester). Chiremba anotsanangura njodzi uye nzira dzekutevera mushure mekusununguka kwauri.
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