Uchapupu hwekushandurwa kwenyaya chena yakatenderedza neurons, progressive multifocal leukoencephalopathy chirwere chetsinga chinokanganisa panguva imwe chete nzvimbo dzakawanda dzehuropi uye chinofambira mberi zvishoma nezvishoma. Zvikonzero zvawo zvakawanda. 

Neurons (masero etsinga muuropi) anowedzerwa netsinga dzetsinga, dzinonzi maaxon, ayo achabatana nevamwe muuropi kuburikidza ne synapses (migumo yeaxon). Idzi tsinga dzetsinga dzakakomberedzwa nesheath (myelin) inovatsaura kubva kune mumwe nemumwe uye chikamu chechinhu chichena cheuropi.

Progressive multifocal leukoencephalopathy (PML) inopupurira shanduko munzvimbo dzinoverengeka dzehuropi hweiyi sheath inotenderedza maaxon, ichikonzera mapfupi maseketi pakati pawo. Aya mapfupi maseketi ari pamavambo ekusashanda zvakanaka kwehuropi maererano nekufambiswa kwemhasuru, kwekuita kwecerebral (kufunga kana kuziva) uye kwetsinga dzetsinga dzekunzwa. Nokudaro kuitika kwekuoma mitezo, kukanganisa kwekufunga uye kunzwa.

Ichi chirwere chinopera simba chetsinga chinowanzo fambira mberi, chichibuda mumakumbo kana zvishoma nezvishoma uye panguva imwe chete chinokanganisa nzvimbo dzakawanda dzeuropi (multifocal). Zvikonzero zvaro zvakawanda uye zviratidzo zvaro zvinoenderana nenzvimbo dzakabatwa.

Zvikonzero zvekufambira mberi kwemultifocal leukoencephalopathy (PML) zvakawanda uye zvakasiyana muzvisikwa:

Nhaka kana kuti genetic

Dzimwe nguva kutanga kwekutanga mune mamwe ma syndromes kana zvirwere zvakaita sechirwere cheCadasil chakabatana neiyo genetic mutation, Childhood Ataxia syndrome pamavambo emakomba emuchena wepfungwa nekuparadzwa kwemyelin, multiple sclerosis (MS) inoitika pa hwaro hwenhaka uye dzimwe nguva zvinokonzeresa cavities (cavitary form of MS), kana zvirwere zvinopera zvehuropi zvakaita senge fragile X syndrome kana chirwere chemitochondrial.

Vascular origin

Iro vascular dementia inokonzerwa nekukuvadzwa kwemidziyo miduku yeuropi (microangiopathy), yakabatana nezera, yekare uye isina kuenzana yakakwirira yeropa kana chirwere cheshuga.

Yechepfu yakabva 

Nokutora mamwe madhiragi akadai semethotrexate anoshandiswa mukurapa mamwe magomarara kana kuti autoimmune zvirwere (rheumatoid arthritis kana RA, nezvimwewo), nitric oxide poisoning (kupisa negasi rakaremara) kana kufema heroin vapors (kupindwa muropa kushandisa). Radiation therapy inogonawo kushandura chinhu chichena chiri muuropi.

Of degenerative origin

Iyo yakabatana nemaitiro ekuzvimba anokanganisa sisitimu yetsinga dzakadai seMS, leucoaraiosis, kana chirwere cheAlzheimer, dzimwe nguva chenhaka, asi kwete nguva dzose, nechirwere chekupedzisira chekuunganidza madhipoziti izvo zvinokanganisa kutapurirana neuronal (amyloid deposits uye neurofibrillary degeneration inobatanidza kuvapo kwemapuroteni muuropi, beta-amyloid peptide uye tau protein).

Inotapukira mavambo

Kashoma muhutachiona hwehutachiona hwakadai sepapillomavirus (JC virus) kana AIDS (2 kusvika 4% yeHIV + vanhu).

Zviratidzo zvekufambira mberi kwemultifocal leukoencephalopathy (PML) zvinosiyana zvichienderana nenzvimbo dzakakanganisika uye chikonzero chekuora uku muuropi:

• kunzwa kupera simba, kunetseka kutaura kana kufunga pakutanga kwechirwere;
• Kudedera nemaune (cerebellar syndrome) uye kuvhiringika kwekufamba mune isina kusimba X syndrome kana chirwere chemitochondrial, kusagadzikana kwekubatana kwekuzvidira, zviratidzo zvinoratidzira kutanga kweaya enhaka kana genetic pathologies uye kufambira mberi zvishoma nezvishoma uye zvisingadzivisiki ...;
• zvirwere zvepfungwa panguva yekuparara kwevascular yakabva, inowanzoitika gare gare kune vakwegura vane mafungiro emafungiro, kuvhiringidzika kwepfungwa (temporo-spatial disorientation, kukanganisa kwekuyeuka), dzimwe nguva kunyengera uye kuvhiringidzika;
• kukanganisa kunzwa uye hunyanzvi hwemotokari mukudzikira kwechepfu mavambo;
• kuderera kwekuziva mukuderera kwehuropi senge chirwere cheAlzheimer chine kukanganisa kurangarira, kutarisisa, kutarisa, kugadzirisa matambudziko, kuronga uye kuronga, kufunga;
• njodzi yecerebrovascular tsaona (stroke) inowedzera mukufambira mberi kwemultifocal leukoencephalopathy;
• migraines uye pfari pfari.

Zviratidzo zvekiriniki zvave kutoratidza nezvechirwere ichi, asi chichava kufungidzira kwehuropi seMagnetic Resonance Imaging (MRI) izvo zvichaita kuti zvikwanise kuwana maronda anoratidza chena yeuropi.

Kuonekwa kwehutachiona hweJC nekuputika kwechiuno dzimwe nguva kunoratidzwa muchiitiko chekufungira kufambira mberi kwehuwandu hwehutachiona hwehutachiona hwehutachiona.

Kuongororwa kweAIDS kunowanzoitwa uye kana kusina, kunofanira kuongororwa.

Kurapa kwekufambira mberi kwemultifocal leukoencephalopathy ndiko kwechikonzero:

• tsvaga zvikonzero zvine chepfu (zvinodhaka, heroin, nezvimwewo) uye zvibvise; 
• kusimbiswa kwekuongororwa kwehutachiona hwehutachiona hweAlzheimer's disease, MS, leukoaraiosis, dementia yevascular origin.

Maronda echinhu chena acharamba asingadzoreki uye tsigiro yepfungwa uye kurudziro yekuziva kunononoka kufambira mberi kwechirwere ichi icho dzimwe nguva chinoshanduka mumakore akati wandei.