-Mapiritsi emazuva ano anorwisa androgen anoshanda zvakanyanya - padanho rega rega rekurapa anogona kuderedza chirwere, kuwedzera hupenyu uye anonyatso kushivirira. Tiri kutaura na Dr. Iwona Skoneczna, PhD, nezve nzira itsva dzekurapa mahormone hadzisati dzawanikwa kuPoles zvizere.
Chiremba, cancer yeprostate yanga ichitora ropa pahuwandu hwekufa kwevarume vePoland kwemakore. Chimwe chezvikonzero "kuramba kwevarume", kureva kutya chiremba weurologist, uye imwe yacho isingakwanisi kuwana mishonga yemazuva ano. Chii chinonyanyorasikirwa nevarwere vePoland?
Kupona uye kufa kwehuwandu mumaneoplasms kunoenderana nezvinhu zvakawanda, asi kazhinji zvinogona kutaurwa kuti chinonyanya kukosha chikamu chekufambira mberi kwechirwere panguva yekuongororwa uye kugona kushandisa zvinobudirira, kazhinji multidisciplinary, kurapwa. Denda iri rakawedzera matambudziko ekuongororwa kumamiriro ezvinhu umo varume vazhinji vaifanira kunyengetedzwa kuti vaongororwe urological.
Ndinoda kudzokorora zvakare kuti gomarara rekutanga reprostate harikonzeri zviratidzo uye kana tikasaedza kutarisa kuti hatina isu pachedu, zvinogona kutishamisa uye kugadzira metastases tisati tazviziva. Chimwe chinhu chakakosha chinotungamirira kumigumisiro yakanaka yekurapa, kunyanya mukenza yeprostate yepamusoro, kuwana mishonga yemazuva ano. Pano zvakare, pasinei nekuvandudzwa, zvakawanda zvinogona kuitwa.
Kubudirira mukurapa kenza yeprostate ndeyekuva antiandrogens yemazuva ano - inoshanda sei?
Tave tichiziva kwemakore anopfuura makumi mashanu kuti kukura kwegomarara reprostate kunoenderana nekuvapo kwemahomoni echirume, kunyanya testosterone. Androgen receptors mumasero emukenza anotora androgens uye kenza inokura nekukurumidza. Mushonga wekutanga uchiri kuderedza mazinga e testosterone. Nokufamba kwenguva, zvakadaro, mhedzisiro iyi inopera, uye maseru egomarara anoburitsa ega androgens kana kutanga kuwanda akazvimirira.
Zvinoitika, zvisinei, kuti ipapo iyo androgen receptor inogona kuvharika zvachose uye bundu kukura kwakadzikira zvakare. Mapiritsi emazuva ano anorwisa-androgen ane maitiro akadaro, anoshanda zvakanyanya, nekuti padanho rega rega rekurapa anogona kunonoka chirwere, kuwedzera hupenyu uye anonyatso kushivirira.
Ndevapi varwere vanozobatsirwa zvakanyanya kubva kune itsva mahormone ekurapa?
Mune oncology, tinoedza kuona mamaki ekutanga kudzoka kuitira kuti tikwanise kurwisa zvine mutsindo kugadzirwa kweanopokana clones nekukurumidza. Mugomarara reprostate rinorapwa nekuvhiyiwa kana kurapwa nemwaranzi, kukwira kwePSA kunova chiratidzo chekutanga chekudzokazve. Kana PSA ikaramba ichiwedzera pasinei nekuderera kwe testosterone, kunyanya kana yakapetwa kaviri mumwedzi isingasviki 10, uye isu tisati taona metastases mukudzora imaging tests (tomography uye bone scintigraphy), maererano neruzivo rwezvokurapa, inguva yekushandisa itsva. zvinodhaka zvehomoni (apalutamide, darolutamide kana enzalutamide). Kana yapihwa kuvarwere panguva ino, vanononoka kutanga kwemetastasis neanenge makore maviri uye vanowedzera rinenge gore kuhupenyu hwese.
Ndeupi mukana weiyo itsva oral hormone kurapwa pamusoro pechemotherapy?
Zvakaoma kuenzanisa intravenous chemotherapy neinotevera-chizvarwa oral hormone therapy. Mishonga miviri inobatsira uye zviri nani kutora mukana wezvose. Zvinokurudzirwa kukurukura chirongwa chekurapa neoncologist, zvose zvezvino uye zvenguva yemberi. Panyaya yechirwere chehasha chechiratidzo, chemotherapy inowanzopihwa sekutanga kurapwa, nepo mune shoma asymptomatic chirwere, tinogona kutanga nehomoni therapy.
Ndeapi maitiro anofanirwa kusangana nemurwere kuti akwanise kuwana nzira nyowani dzekurapa cancer yeprostate muPoland?
Kurapa kwemazuva ano kwehomoni yegomarara reprostate padanho rekuramba kudzikisa testosterone rinowanikwa chete kune varwere vanosangana nezvinodiwa zvezvinonzi zvirongwa zvemishonga. Kwemazuva ano, izvi zviratidzo zvinongosanganisira vanhu vane metastases yakasimbiswa, isu takamirira nguva iyo isu tichakwanisa kunonoka kuonekwa kwemasastases tichishandisa mishonga iyi.
Kuwanikwa kwemishonga yemazuva ano kunotaridzika sei kune dzimwe nyika dzeEuropean Union?
Munyika zhinji dzeEU, mishonga mitsva yemahomoni inowanikwa padanho rekutanga rekurapa kupfuura muPoland.
Sei mukuona kwako mishonga mitsva yegomarara reprostate isingadzoserwe uye pane mukana wekuchinja munguva pfupi iri kutevera?
Handikwanise kuwana mhinduro kumubvunzo wekutanga, uye kune wechipiri: Ndinovimba zvakadaro.