Neuroleptic malignant syndrome inonzi pathology inoratidzwa nechirwere pahutano hwehutano. Ichi chirwere chinowanzo mhedzisiro yemhedzisiro kana uchitora zvinodhaka senge neuroleptics kana anti-psychotics. (2)

Ichi chirwere chakabatana neidiosyncratic state, kureva nzira yekuve yemunhu wega wega, maitiro ake uye maitiro ake nenharaunda yake.

Iyi pathology inotungamira kune yakanyanya kupisa, kudikitira, kusagadzikana maererano neBP, mhasuru kuomarara uye dysfunctions mune automatisms.

Muzviitiko zvakawanda, zviratidzo zvekutanga zvinoonekwa mushure memavhiki maviri ekurapa neuroleptics kana anti-psychotics. Zvisinei, zviratidzo zvine chokuita nechirwere zvinogona kuonekwa munguva yose yekutora mishonga.

Mhosva dze neuroleptic malignant syndrome dzakaunzwa zvakare pamberi zvichitevera kusaenderera mberi kurapwa nemishonga inorwisa-Parkinson. (2)

Kukurumidza kuongororwa kweuroleptic malignant syndrome inokonzerwa nekutora neuroleptics kana anti-psychotics inoita kuti zvibvirire kuderedza migumisiro yakabatana.

Neuroleptic malignant syndrome inokanganisa anenge 1 kusvika ku2 kesi muvarwere gumi vari kurapwa neuroleptic kana antipsychotic. Kuwanda uku kunobata varume nevakadzi vane hutongi hushoma hwevarume, vemazera ese. (10)

Neuroleptic malignant syndrome inosanganiswa nemhando dzakasiyana dzekiriniki dzakadai se: (1)

• pyrexia: kuvapo kwefivha yakasimba kana chirwere chisingaperi chine febrile;
• musuru hypertonia: kuwedzera inzwi mumhasuru;
• kuchinja kwezvimiro zvendangariro;
• haemodynamic deregulation (kuderedzwa mukutenderera kweropa)

Chimiro chakananga kune neuroleptic malignant syndrome kuvepo kweakakosha muscular rigidity inoenderana nekusavapo kwemafungiro: "lead-pipe" kusimba. (1)

Hunhu maererano nezviratidzo zvakakosha zvinoonekwawo murudzi urwu rwechirwere: (4)

• neBP;
• tachycardia (kurova kwemoyo nekukurumidza);
• tachypnea (kukurumidza kufema);
• hyperthermia (> 40 °), inokonzerwa nekuvapo kwefivha yakasimba;
• hypersalivation;
• acidosis (acidification yeropa ine pH yakaderera pane yakajairika level iri pakati pe7.38 ne7.42.);
• kusagadzikana.

Shanduko mubiological parameters dzinoonekwawo murudzi urwu rwechirwere: (4)

• yakakwirira ye serum phosphokinases uye transaminases;
• rhabdomyolysis (kuparara kwemhasuru tishu mukati memhasuru dzakatemerwa).

Kubudirira kweurouroleptic malignant syndrome kunobva pamigumisiro yakaipa inobatanidza nekutora mishonga yemhando: neuroleptics uye anti-psychotics.

Chinhu chinonyanya kukosha mungozi mukugadzirwa kweurouroleptic malignant syndrome ndiko kushandiswa kweurouroleptics kana anti-psychotics. (4)

Mukuwedzera, kuneta kwemuviri, kusagadzikana, kupera simba kune zvimwe zvinhu maererano nehutano hwekuita chirwere.

Varwere vanotora neuroleptics kana anti-psychotics pahupamhi hwepamusoro, muchimiro chevabereki (kutungamirirwa kwechirwere nenzira ye intravenous, intramuscular, etc.) kana nekuwedzera kwekukurumidza muyero vane ngozi huru yekuvandudza chirwere chacho. (4)

Kurapa kwechirwere ichi kunowanzova kwakanyanya.

Mushonga unokonzera chirwere (neuroleptic kana antipsychotic) unomiswa uye fivha inorapwa zvakanyanya.

Mishonga inobvumira kuzorodza tsandanyama inogona kunyorwa. Mukuwedzera, dopamine-based treatments (dopaminergic drugs) inowanzobatsira mukurapa kwechirwere ichi. (2)

Parizvino, hapana kurapwa kwakananga kweiyi syndrome kwave kuri nyaya yehumbowo hwechokwadi.

Zvakadaro, zvakanakira kurapwa nebenzodiazepines, dopaminergic agents (bromocriptine, amantadine), dantrolenes (muscle relaxants) uye electroconvulsive therapy zvakataurwa.

Kunyatsotarisa kunofanirwa kuvarwere vane cardio-respiratory failure, renal failure, aspiration pneumonia uye coagulopathy.

Mukuwedzera, rubatsiro rwekufema uye dialysis inogona kurongerwa.

Muzviitiko zvakawanda, varwere vane neuroleptic malignant syndrome vanoita kupora kwakakwana. Nekudaro, zviratidzo zveamnesic, extrapyramidal (pamwe chete neurological disorders), kusagadzikana kwehuropi, peripheral neuropathy, myopathy uye zvibvumirano zvinogona kuenderera mune dzimwe nguva. (4)

Kana pasina kurapwa uye mushure mekumisa mushonga wepsychotropic unokonzera chirwere, neuroleptic malignant syndrome inowanzorapwa pakati pevhiki imwe ne1.

Mukuwedzera, iyo syndrome inogona kuuraya.

Zvikonzero zvekufa mumamiriro echirwere ichi ndezvekusungwa kwemwoyo, aspiration pneumonia (kubatanidzwa kwepulmonary kunoratidzwa nereflux yemvura mubronchi kubva mudumbu), pulmonary embolism, myoglobinuric renal failure (renal kukundikana nekuvapo kweropa muweti). , kana kuparadzira intravascular coagulation. (4)

Huwandu hwekufa hunoenderana neiyi pathology huri pakati pe20 ne30%.