Purpura fulminans chirwere chinotapukira chinomiririra yakanyanya kuomarara sepsis. Inokonzera ropa kugwamba uye tishu necrosis. Inowanzokonzerwa nehutachiona hwemeningococcal uye mhedzisiro yacho inouraya kana isina kutarisirwa nenguva.

Kupisa kwakanyanya, kukanganisa kwakadzika kwemamiriro ezvinhu, kurutsa uye kurwadziwa kwepamuviri ndiyo yekutanga uncharacteristic zviratidzo. Imwe kana mamwe mavara matsvuku uye epepuru anopararira nokukurumidza paganda, kazhinji pamakumbo ezasi. Izvi zvinonzi purpura, kubuda ropa kweganda. Kudzvinyirirwa paganda hakugadziri ropa uye hakuiti kuti tsvina iparare kwekanguva, chiratidzo che "extravasation" yeropa mumasumbu. Izvi zvinodaro nekuti Purpura Fulminans inokonzera kuparadzirwa intravascular coagulation (DIC), inova kuumbwa kwemagwamba madiki anozokanganisa kuyerera kweropa (thrombosis), achitungamira kune dermis uye kukonzera kubuda kweropa uye necrosis yeganda tishu. Iyo infectious syndrome inogona kuperekedzwa nemamiriro ekuvhunduka kana kukanganisa kwekuziva kwemunhu abatwa.

Muhuwandu hwakawanda hwezviitiko, purpura fulminans inosanganiswa neiyo invasive uye yakanyanya hutachiona hwehutachiona. Neisseria meningitidis (meningococcus) ndiyo inonyanya kutapurira chirwere ichi, ichiverengera chikamu chinosvika makumi manomwe neshanu muzana. Ngozi yekukura purpura fulminans inowanikwa mu75% ye invasive meningococcal infections (IIMs). (30) 2 kusvika ku1 nyaya dzeIMD pavagari ve2 dzinoitika gore rega rega muFrance, ine chiyero chekufa kwechinenge 100%. (000)

Mamwe mabhakitiriya maajenti anogona kuve ane chekuita nekuvandudzwa kwepurpura fulminans, senge Streptococcus pneumoniae (pneumococcus) kana Haemophilus influenzae (Pfeiffer's bacillus). Dzimwe nguva chinokonzera kushayikwa kweprotein C kana S, iyo inobata basa mukubatana, nekuda kwekusagadzikana kwemajini: kuchinja kwePROS1 gene (3q11-q11.2) yeprotein C uye PROC gene (2q13-q14) yeprotein C. Inofanira kuonekwa kuti purpura fulgurans inogona kuguma nehutachiona hunyoro hwakadai sehuku, muzviitiko zvisingawanzoitiki.

Purpura fulminans inogona kukanganisa chero zera, asi vacheche vari pasi pemakore gumi nemashanu ekuberekwa uye vechidiki vane makore makumi maviri kusvika kumakore ekuberekwa vari panjodzi huru. (15) Vanhu vanga vari padhuze neakabatwa septic shock vanofanirwa kuwana kurapwa kweprophylactic kudzivirira chero njodzi yekutapukirwa.

Iyo prognosis yakabatana zvakananga nenguva inotorwa kutora chigaro. Purpura fulminans zvirokwazvo inomiririra mamiriro ekiriniki ekukurumidzira kwakanyanyisa kunoda kurapwa kwemishonga inorwisa mabhakitiriya nekukurumidza sezvinobvira, pasina kumirira kusimbiswa kwekuongororwa uye kusaiswa kune yekutanga mhedzisiro yetsika yeropa kana kuongororwa ropa. Purpura inoumbwa neinenge nzvimbo imwe ine dhayamita yakakura kupfuura kana yakaenzana nemamirimita matatu, inofanira kubva yatanga chenjedzo uye kurapwa. Mishonga inorwisa mabhakitiriya inofanira kunge yakakodzera kune zvirwere zvemeningococcal uye inoitwa intravenously kana, kukundikana, intramuscularly.