Tsanangudzo yePUVA therapy 

PUVA therapy inosanganisa kuratidzwa kune yakagadzirwa sosi yeUVA mwaranzi nekurapa kunoenderana nepsoralen, UV inokurudzira chigadzirwa. Saka acronym PUVA: P inoreva Psoralen uye UVA kune ultraviolet mwaranzi A.

Musimboti

Kuratidzwa kuUVA kunokonzeresa kuburitswa kwezvinhu zvinonzi cytokines, zvinova nezviito zviviri:

• inonzi antimitotic action, iyo inoderedza kupararira kwemasero epidermal;
• an immunological action, iyo inozodzikamisa kuzvimba.

Chiratidzo chikuru chePUVA-kurapa kurapwa kweakanyanya psoriasis vulgaris (madonhwe, medallions kana zvigamba) akapararira munzvimbo dzakakura dzeganda.

Sechiyeuchidzo, psoriasis chirwere chinoputika cheganda nekuda kwekukurumidza kuvandudzwa kwemasero epidermis, keratinocytes. Sezvo ganda risina nguva yekuzvibvisa pacharo, epidermis inowedzera, zviyero zvinounganidza uye zvinobva zvabuda, zvichisiya ganda rakatsvuka uye rinopisa. Nekudzikamisa kuzvimba uye kudzikamisa kuwanda kwemasero epidermal, PUVAtherapy inobatsira kuderedza psoriasis plaques uye nzvimbo kunze flare-ups.

Zvimwe zviratidzo zviripo:

• atopic dermatitis apo kuputika kwakakosha zvikuru uye kunopesana nekuchengetedzwa kwenharaunda;
• danho rekutanga cutaneous lymphomas;
• photodermatoses, zvakadai sezhizha lucitis somuenzaniso, apo photoprotective kurapwa uye kudzivirirwa kwezuva kusina kukwana;
• polycythemia pruritus;
• ganda lichen planus;
• zvimwe zviitiko zvakanyanya alopecia areata.

Nyanzvi

Zvirongwa zvePUVA-therapy zvinotarwa nedermatologist uye zvinoitika muhofisi kana muchipatara chine irradiation cabin. Vanofukidzwa neSocial Security mushure mekugamuchira chikumbiro chechibvumirano chekutanga.

Nzira yechikamu

Zvakakosha kuti usashandise chero chinhu paganda risati rasvika. Maawa maviri zvisati zvaitika, murwere anotora psoralen nemuromo, kana zvakanyanya kashoma kumusoro, nekunyudza chikamu chemuviri kana muviri wese mune aqueous solution yepsoralen (balneoPUVA). Psoralen ndeye photosensitizing agent inoita kuti zvikwanise kuwedzera kushanda kweUV kurapwa.

UVA inogona kupihwa muviri wese kana munharaunda (maoko netsoka). Chikamu chinotora kubva pa2 kusvika kumaminitsi gumi nemashanu. Murwere akashama, kunze kwenhengo dzakavandika, uye anofanira kupfeka magirazi matema-opaque kuti azvidzivirire kubva kumwaranzi yeUVA.

Mushure memusangano, zvakakosha kupfeka magirazi ezuva uye kudzivisa kusvibiswa kwezuva kwemaawa matanhatu.

Kuwanda kwezvikamu, nguva yavo uye iyo yekurapa kunotsanangurwa nedermatologist. Rhythm yezvikamu zvinowanzova zvikamu zvakati pavhiki (kazhinji zvikamu zvitatu zvakaparadzana maawa makumi mana nemasere), zvichiunza zvishoma nezvishoma kuwedzera kweUV. Zvirongwa zve3 zvinodikanwa kuti uwane mhedzisiro yaunoda.

Zvinokwanisika kusanganisa PUVA therapy neimwe kurapwa: corticosteroids, calcipotriol, retinoids (re-PUVA).

Contraindications

PUVA therapy inorambidzwa:

• panguva yepamuviri uye lactation;
• muchiitiko chekushandiswa kwe photosensitizing zvinodhaka;
• chiropa uye itsvo kukundikana;
• mamiriro eganda anokonzerwa kana kuwedzera ne ultraviolet chiedza;
• kenza yeganda;
• kukanganisa kwekamuri yepamberi yeziso;
• acute infection.

Zvikanganiso uye njodzi

Ngozi huru, kana paine akawanda PUVA therapy masesheni, ndeyekuita gomarara reganda. Iyi njodzi inofungidzirwa kuwedzera apo nhamba yezvikamu, zvakabatanidzwa, zvinodarika 200-250. Uyewo asati aronga zvirongwa, chiremba wedermatologist anoita kuongorora kweganda kwakakwana kuti aone mumurwere munhu angangove ane ngozi yekenza yeganda (yemunhu pachake nhoroondo yekenza yeganda, kuratidzwa kwekare ku-X-rays, kuvapo kweganda rekare rekare, nezvimwewo) . Panguva imwecheteyo, gore negore dermatological monitoring inokurudzirwa kune vanhu vakagamuchira zvinopfuura 150 phototherapy sessions, kuitira kuti vaone zvipembenene zveprecancerous kana kenza yepakutanga panguva yekutanga.

Mild side effects inowanzoonekwa:

• kusvotwa nekuda kwekutora Psoralen;
• kuoma kweganda kunoda kushandiswa kwe emollient;
• kuwedzera kwebvudzi rinozopera kana zvirongwa zvamira.