Mukati
Migumisiro yekuongorora kwehupenyu, kuratidza huwandu hwecholesterol muropa, inobvumira nyanzvi kuti anyore mishonga yakakodzera. Statins inowanzokurudzirwa kudzivirira matambudziko emwoyo munyaya iyi.
Kazhinji, chiremba anoenda, achirondedzera mari yakadaro, pakarepo anonyevera murwere kuti vanofanira kutorwa pasina kuputika kwenguva refu. Mukuwedzera, semamwe madhiragi, ma statins ane akasiyana mhedzisiro pamuviri. Murwere anofanira kujekesa pfungwa iyi pakugadzwa nachiremba wake. Mushure mezvose, basa guru rine high cholesterol nderokuderedza chiyero chayo. Chigumisiro chinowanikwa nerubatsiro rwemishonga yemishonga. Zvisinei, mishonga inofanira kutangwa muzviitiko zvose here? Ko mugumisiro unoshuviwa uchawanwa nebetsero yavo here?
Zvinoreva zveboka refibrate kana statins inoderedza cholesterol. Iwe unogona kuwedzera maitiro avo nekutora lipoic acid uye Omega-3 fatty acids panguva imwe chete. Ichi chinyorwa chakatsaurirwa kumishonga yemishonga inoderedza cholesterol, maitiro ekushandisa kwavo uye nemigumisiro.
Kuderedza Cholesterol neStatins
Iro pharmacological boka re statins rinosanganisira mishonga ine chinangwa chikuru kudzikisa kuburitswa kweakananga enzymes anobatanidzwa mukuumbwa kwecholesterol.
Mukutsanangurwa kwemishonga iyi uye mahwendefa, zvinotevera zvivakwa zvinopihwa:
Vanoita se inhibitor kurwisana neHMG-CoA reductase, nokudaro kuderedza cholesterol, kuderedza kugadzirwa kwayo;
Vanoshanda kunyangwe paine concomitant chisingaperi zvinodhaka. Semuenzaniso, homozygous mhuri hypercholesterolemia haizokanganisa kushanda kwe statins;
Iva nemigumisiro yakanaka pamhasuru yemwoyo, kuderedza mukana wekurwadziwa kwemoyo uye angina pectoris;
Mushure mekutora mishonga, HDL-cholesterol uye apolipoproteinA inowedzera muropa;
Kusiyana nemimwe mishonga yakawanda, statins haisi mutagenic kana carcinogenic.
Kwete nguva dzose mishonga inobatsira muviri. Statins inogona kukonzera mhedzisiro inotevera:
Kushaya hope, musoro, kuda kurutsa, manyoka, myalgia;
Amnesia, kushaya simba, hypesthesia, neuropathy, paresthesia;
Kusagadzikana mumisumbu yemusana, makumbo, myopathy, convulsions;
Kurutsa, anorexia, cholestatic jaundice;
Allergic reaction, inoratidzwa nekuputika kweganda uye kuputika, urticaria, anaphylaxis, exudative erythema;
Kudonha kweshuga yeropa, iyo inobatsira pakukura kwechirwere cheshuga uye hypoglycemia;
Kuwedzera kuwandisa;
kukura kwekushaya simba.
Ndeapi ma statins akakosha?
Tsananguro dzeakawanda ma statins ane ruzivo runoratidza zvinobatsira zvemishonga. Kuderedza njodzi yechirwere chemoyo, normalizing cholesterol mazinga, kudzivirira kurwiswa kwemwoyo - zvose izvi zvinogadziriswa zvinopiwa nenzira yeboka iri remishonga, maererano nemakambani ekushambadzira. Zvisinei, ndizvo zvazviri chaizvo here? Mushure mezvose, mutengo wemishonga yakadaro wakakwira, saka ruzivo nezve mabhenefiti eiyo statins kuedza kukwezva vatengi? Dzakanakira utano here?
Pasinei nemigumisiro yezvidzidzo zvinoratidza kusavapo kwekukuvadza kwemishonga pamuviri wemunhu, vashoma nyanzvi vanogona kukurudzira nechivimbo statins kuti vabvumirwe. Izvi ndezvechokwadi kunyanya kuvarwere vakura. Kune rimwe divi, zviedzo zvakaratidza kuti kurapa kwezvinodhaka nema statins kunobatsira mukudzikisa cholesterol. Vanodzivirirawo kubva kune dzakawanda zvirwere zvakakomba. Asi nyanzvi dzakawanda dzine maonero akasiyana, achitenda kuti mhedzisiro yakanaka yema statins inosanganiswa nenjodzi huru. Mikana yemigumisiro yakanyanyisa, iyo ine ngozi kune varwere vakwegura.
Panguva imwecheteyo, zvinodhaka zveboka iri zvinosungirwa zvakatemwa muzviitiko zvinotevera:
Ndeipi kudzivirira kwechipiri kune varwere vane chirwere chemwoyo kana sitiroko;
Nechirwere cheischemic nekutyisidzira kwekugadzirisa matambudziko akasiyana-siyana;
Ne coronary syndrome kana kurwisa kwemoyo;
Coronary artery bypass kuvhiyiwa kunosanganisirawo kutora statins.
Kushandiswa kwema statins pamberi pechirwere cheshuga mellitus, pamwe chete nevakadzi vasina kusvika zera rekuenda kumwedzi, hazvikurudzirwe. Hapana chikonzero chekutora zvinodhaka kana zvichibvira kutsvaga mamwe madhiragi kuti udzivise mhedzisiro.
Mafemasi eRussia anopa kushandisa anotevera statins ane akasiyana chiitiko:
Rosuvastatin: Acorta, Crestor, Mertenil, Rosuvastatin, Rosucard, Rosulip, Roxera, Tevastor
Lovastatin: Cardiostatin, Choletar, Cardiostatin
Atorvastatin: Atomax, Atorvastatin Canon, Atoris, Liprimar, Torvacard, Tulip, Liptonorm
Fluvastatin: Leskol Forte
Simvastatin: Vasilip, Zokor, Ovencor, Simvagexal, Simvard, Simvastatin, Simvastol, Simvor, Simgal, Simlo, Sinkard
Mishonga inowanikwa nenzira dzakasiyana-siyana, mari yavo inosiyanawo.
Ungasarudza sei statins?
Murwere anofanira kuzvisarudzira ega kana otora ma statins. Muchiitiko ichi, unofanira kutanga waonana nenyanzvi ine unyanzvi uyo, kana zvichidiwa, achanyora mushonga chaiwo. Hazvikurudzirwi kuita chero chiito pasina rubatsiro rwechiremba. Kana kuongororwa kweropa rebiochemical kunoratidza kuvapo kwehupi hupi hupi husina kunaka, unofanirwa kushanyira murapi uye endocrinologist. Zvechokwadi, pakusarudza statins, chiremba anotarisa kune zvepabonde, zera uye kunyange uremu hwemurwere, anofunga kana ane maitiro akaipa uye zvirwere zvisingaperi.
Panguva yekurapa, zvinodikanwa kuomerera kune dosage yakagadzwa nenyanzvi, nguva dzose kutora miedzo. Kana mushonga unotengeswa kunze kwenyika unokurudzirwa nachiremba usipo nekuda kwemutengo wakakwira, wakajairika kune mazhinji ma statins, unogona kugara uchiwana inodhura yemumba analogue. Kunyangwe izvi zvingakanganisa kushanda kwechishandiso.
Zvakakosha kuyeuka kuti zvakachengeteka kutora dosi shoma yerosuvastatin mune chisingaperi chiropa pathologies, iyo inogona kutsiviwa ne pravastatin. Iwe haugone kusanganisa zvinodhaka nedoro kana antibiotics. Mukana wakakura wepravastatin zvakare yakaderera toxicity, ndosaka ichiratidzwa kune varwere vane kurwadziwa kwemasuru. Iko mukana wekubatanidza statins uye nicotinic acid zvakare inoramba iri nyaya ine gakava. Pane pfungwa yokuti izvi zvinogona kukonzera kuwedzera kwezvirwere zvisingaperi.
Sei statins ine ngozi?
MuRussia, mishonga yakanyatsorongedzerwa mushure meAmerica vanachiremba. Chirwere cheIschemic, arterial hypertension - zvirwere izvi zvose zvakarapwa nema statins. Muchiitiko ichi, mishonga yakakura yakashandiswa. Zvisinei, muUnited States, tsvakurudzo yakaitwa munguva pfupi yakaratidza kubatana pakati pekukura kwezvirwere zvakawanda uye kushandiswa kwema statins. Muna 2013, British Medical Journal yakabudisa ruzivo pamusoro pemigumisiro yavo yakaipa pahutano hwevarwere. Asi kwakanga kusina zvidzidzo zvakasununguka muRussia, uye nyanzvi dzinoramba dzichishandisa zvinodhaka zveboka iri.
MuCanada, zvakaonekwa kuti varwere vakwegura vanovatora vanowanzoona kukurumidza kuparara kwekuona uye kukura kwecataract. Ngozi inowedzera zvakanyanya muhupo hwechirwere cheshuga.
Zvimwe zvinhu zvinomutsa kusava nechokwadi pamusoro pezvakanakira statins:
Zvinodhaka zvinogona kukanganisa cholesterol kuitira kuti ive pasi penguva dzose, iyo ine ngozi kupfuura kudarika kwayo. Inogona kukonzera mapundu akaipa, chirwere chechiropa, anemia, sitiroko, kuzviuraya uye kuora mwoyo.
Statins inovhiringidza basa rekudzorera cholesterol. Kutenda kune cholesterol, kukanganisa kunobviswa mumuviri. Izvi zvinokonzerwa nekuti ndechimwe chezvinhu zvakakosha mukuumbwa kwemavanga mavanga. Zvakare, yakaipa cholesterol yakakosha pakukura kwemhasuru uye muviri wese. Kushaikwa kwayo kunokonzera kurwadziwa kwemhasuru uye dystrophy.
Kushaikwa kweMagnesium, kwete cholesterol yakawandisa, inotungamira kune sitiroko uye kurwisa kwemoyo. Iyi hypothesis inokanda kusahadzika pakudiwa kwekushandiswa kwema statins.
Pamwe chete nekuderera kwemazinga echolesterol, kuumbwa kwezvimwe zvinhu zvakawanda zvakakosha mumuviri kunoderedzwawo. Izvi zvinoshanda kumukomboni wakadai semelovanate. Inobatanidzwa mumabasa akawanda ehupenyu, kusanganisira kuumbwa kwecholesterol.
Kuita kwema statins kunomutsa chirwere cheshuga, icho chinozokanganisa kugadzirwa kwecholesterol uye chinobatsira pakuitika kwezvimwe zvirwere. Ichi chikonzero, maererano nevatsvakurudzi veGermany, chinokonzera angina pectoris uye arrhythmia, sitiroko. Izvi zvinoitika nekuda kwekuderera kwehuwandu hweprotein inokonzeresa huwandu hweshuga yeropa. Zvinoenderana nemhedzisiro yetsvakiridzo, vakadzi vari muzera rekuenda kumwedzi vari panjodzi.
Pane matambudziko muuropi nekuda kwekutora zvinodhaka. Chekutanga pane zvese, ma statins anokanganisa cholesterol metabolism, inokanganisa kushanda kwechiropa. Panguva imwecheteyo, mishonga ine simba rakanaka pamidziyo yeropa. Zvisinei, chero simba remakemikari rinokanganisa muviri. Somugumisiro, kuchinja kusingagadziriswi kunoitika muhutano hwehupenyu, kusanganisira kushanda kwepfungwa kunogona kuvhiringidzika.
Migumisiro yemigumisiro ye statins inowanzoonekwa yakanonoka.
Mamwe masayendisiti, achifunga nezve cholesterol yakakwira sechisimbiso chekuvapo kwezvirwere zvakakomba, anosimbisa kushushikana uye kumwe kuzvimba sezvikonzero zvemoyo pathologies. Nyika dzinoverengeka dzakagara dzichikurudzira mararamiro ane utano kuitira kudzivirira zvinetso mubasa remwoyo. Nekuda kweizvi, nhamba yevarwere vane pathologies yakadai yakadzikira, izvo zvakaratidza kuti cholesterol inogona kugadziriswa nekusiya tsika dzakaipa uye kusarudza mitambo uye kudya kwakaringana. Saka, mararamiro ane hutano anokubvumira kuti urege kutora mishonga yakasiyana-siyana ine nhamba yakawanda yemigumisiro, uye kudzivirira kukura kwehutachiona hunotyisa.
Chimwe chinhu chakaipa kubva pakutora statins
Maererano nekumwe kuongorora kwevanhu 3070 vane makore 60 uye kupfuura, kushandiswa kwe statin kunokonzera kurwadziwa kwetsandanyama mu30% yevanhu, izvo zvinoderedza kushanda kwavo kwemuviri. Somugumisiro wekuwedzera kurwadziwa mumasumbu, varwere vanoramba kutamba mitambo, kufamba zvishoma. Zvose izvi zvinokonzera kuwedzera uremu uye kuwedzera njodzi yechirwere chemoyo.
Mafibrates Anobatsira Kudzikisa Cholesterol
Fibric acid derivatives inozivikanwa sefibrate inowanzoshandiswa seimwe nzira kune statins. Vanoita zvakananga pachiropa, vachideredza kubuda kwayo kwecholesterol. Fibrates inokanganisawo huwandu hwe lipids, inoderedza kuumbwa kwe extravascular deposits. Mushure mekutora mishonga iyi, mwero wezvose zvakanaka uye zvakaipa cholesterol inogadziriswa.
Pamwe chete nemhedzisiro yakanaka, mafibrate anewo maitiro asina kunaka, anoratidzwa nenzira ye:
Hepatitis, pancreatitis, manyoka, kusvotwa, kurutsa, kurwadziwa mugayo;
Venous thromboembolism, pulmonary embolism;
kushaya simba kwetsandanyama uye spasms, kuparadzira myalgia;
misoro, kusagadzikana kwepabonde;
Kunzwa kwechiedza uye allergic reactions.
Kazhinji, kurapwa kwakaoma kunoshandiswa, kunosanganisira musanganiswa wefibrate uye statins. Nokudaro, zvinokwanisika kuderedza chiyero chekupedzisira.
Fibrates inomiririrwa nezvizvarwa zvitatu:
Clofibrate - yakapera fibrate yechizvarwa chekutanga, ikozvino haichashandiswi, sezvo yakaratidza kuti inobatsira pakuonekwa kweoncology;
Gemfibrozil, bezafibrate - chimiro chakafanana chaizvo ne clorifibrate, asi ine huturu hushoma. Inonziwo isingachashandi, ikozvino haichawanzoshandiswa;
Fenofibrate, Ciprofibrate - ndeye 3rd chizvarwa chefibrates, ikozvino ndiyo inonyanya kufarirwa. Mukuwedzera pakuderedza cholesterol, inoderedza huwandu hweuric acid, uye inoderedzawo mukana wezvinetso zvechirwere cheshuga. Kutengeswa pasi pemazita ekutengeserana Traykor (France), Lipantil 200 M (France), Fenofibrate Canon (Russia), Exlip (Turkey).
Kuderedza intestinal absorption yecholesterol
Zvizhinji zvezvinodikanwa zvezuva nezuva zvecholesterol zvinosangana nemuviri, zvakasara zvinozadzikiswa nekudya.
Normalization yecholesterol mazinga nemaitiro ekugadzirira
Vanachiremba vazhinji vanokurudzira panzvimbo yema statins uye mafibrate kudzikisa cholesterol mazinga nenzira dzinotevera:
Omega-3 mafuta acids. Iwo anowanikwa muhuwandu hukuru mumafuta ehove nemafuta eflaxseed, uye anoshanda seprophylactic kurwisa sitiroko, kusagadzikana kwekutya, uye arthritis. Panguva imwecheteyo, kuyerwa kwemafuta ehove hakufanirwe kutyorwa, nekuti kuwanda kwayo kunogona kukonzera pancreatitis.
Nhanga. Mushonga uyu wechisikigo mafuta embeu yenhanga. Inoshandiswa kudzivirira atherosclerosis yecerebral midziyo, hepatitis, cholecystitis, ine anti-inflammatory, hepatoprotective, choleretic uye antioxidant migumisiro.
Lipoic acid. Inodzivirira coronary atherosclerosis, mhedzisiro pazinga re glycogen muchiropa. Nerubatsiro rwe lipoic acid, neuronal trophism inogona kuvandudzwa.
Vitamin therapy. Iyo yakanakisa sosi yezvinhu zvinodiwa kumuviri ichava zvigadzirwa zvechisikigo zvakapfuma municotinic uye folic acid, mavhitaminzi B3, B6, B12.
zvokudya zvokuwedzera Pakati peizvi, zvakakodzera kushandisa SitoPren - fir foot extract. Iine beta-sitosterol, iyo yakagadzirwa inewo polyprenols, inobatsira mu atherosclerosis, chirwere cheshuga.