Chirwere cheBehçet chirwere chine chekuita nekuzvimba kwemitsipa yeropa. Inonyanya kuratidzwa nemaronda emumuromo kana pamitezo, asiwo nekukuvara kwemaziso, ganda kana majoini. Zvimwe zvinonyanya kuratidzwa zvine chekukuvara kwenzara kana kugaya, venous thrombosis uye arterial aneurysms pamwe nekumwe kukuvara kwemaziso uko kunogona kukonzera kupofomara. Kurapa kunonyanya kuratidzira uye kunogona kusanganisira colchicine uye corticosteroids ine kana isina immunosuppressants yeakanyanya kuratidzwa.

Chirwere ichi chakatanga kutsanangurwa nedermatologist Behçet muna 1934. Chinotarisa chirwere chekuputika chinogona kusanganisira vasculitis, ndiko kuti kuzvimba, kwetsinga uye / kana tsinga dzediki kana hombe caliber. , pamwe netromboses, ndiko kuti kugwamba kunogadzirawo mutsinga uye / kana mutsinga.

Chirwere chaBehçet chinowanikwa muMediterranean Basin uye muJapan. Inobata vese varume nevakadzi asi inowanzo kuve yakanyanya kuvarume. Inowanzoitika pakati pemakore gumi nemasere kusvika makumi mana uye inogona kuonekwa muvana. 

Inoshanduka mukumhanya, inopindirwa nenguva dzekuregererwa. Iyo dzimwe nguva inogona kuuraya, zvichitevera kunetseka kwetsinga, vascular (ruptured aneurysm) kana kusagadzikana kwepamuviri. Huwandu hukuru hwevarwere vanozopedzisira vaenda mukuregererwa.

Chikonzero chechirwere chaBehçet hachizivikanwe. 

Zvinokonzera immune, zvinosanganisira autoimmune zvinokonzeresa, uye hutachiona (semuenzaniso herpes hutachiona) kana hutachiona (semuenzaniso streptococci) inogona kuve inobatanidzwa. Iyo HLA-B51 allele ndiyo huru njodzi chinhu. Chokwadi, vatakuri veiyi allele vane njodzi yekuvandudza chirwere 1,5 kusvika 16 nguva dzakakwirira zvichienzaniswa nevasiri vatakuri.

Zviratidzo zvekiriniki zvechirwere cheBehçet zvakasiyana uye zvinogona kuremadza mumabasa ehupenyu hwezuva nezuva. Izvi zvinosanganisira:

• kukuvara kweganda kwakadai semaronda emumuromo aripo mu98% ematambudziko, maronda ekurara panjodzi aripo mu60% ezviitiko uye akasarudzika ari mune varume pachiganda, pseudo-folliculitis, dermo-hypodermic nodules aripo mu30 kusvika 40% yematambudziko;
• kubatana kukuvara, senge arthralgia uye kuzvimba oligoarthritis yemakuru majoini (mabvi, makumbo), aripo mu50% emakesi;
• kukuvara kwemhasuru, pane kushomeka;
• kukuvara kwemaziso, senge uveitis, hypopyon kana choroiditis, iripo mu60% yematambudziko, uye ichikonzera matambudziko akakura senge cataract, glaucoma, kupofomara;
• kukuvara kwetsinga kuripo mu20% yematambudziko. Kufuridzira-kumusoro kunowanzotanga nefivha uye nemusoro. Zvinosanganisira meningoencephalitis, kukuvara kune cranial tsinga, thrombophlebitis yeuropi sinuses;
• kukuvara kwevascular: venous thrombosis, kazhinji iri pamusoro, iripo mu30 kusvika 40% yematambudziko; arterial kukuvara, kushoma, senge yekuzvimba arteritis kana aneurysms;
• chirwere chemwoyo, chisingawanzo, senge myocarditis, endocarditis kana pericarditis; 
• gastrointestinal kusagadzikana, zvisingawanzoitika muEurope, zvinoratidzwa nekunetseka kwemudumbu, kurwadziwa mudumbu uye manyoka nemaronda emudumbu, zvakafanana nekumuka kwechirwere cheCrohn kana ulcerative colitis;
• zvimwe zvisingawanzo kuitika zvinokwanisika, kunyanya renal uye testicular.

Iko hakuna kurapwa kwechirwere cheBehçet. Mishonga iriko inovavarira kudzora chirwere nekuderedza kuzvimba.

Iwo manejimendi echirwere cheBehçet ndeye multidisciplinary (general chiremba, ophthalmologist, internist, nezvimwewo). Kurapa kunoenderana nekuratidzwa kwekiriniki:

• colchicine (1 kusvika 2 milligrams pazuva) inoramba iri hwaro hwekurapa, kunyanya kukuvara kweganda uye kwemajoini. Inogona kunge yakakwana mumhando dzakapfava;
• neurological, ocular uye vascular kukuvara kunoda kurapwa necorticosteroids kana immunosuppressants (cyclophosphamide, azathioprine, mycophenolate mofetil, methotrexate) nehurongwa;
• mune mamwe mafomu akakomba ocular, alpha interferon inogona kushandiswa nemajekiseni epasi;
• anti-TNF alpha antibodies ari kuwedzera kushandiswa mumhando dzakakomba dzechirwere kana mafomu anopesana nemishonga yapfuura;
• mishonga yemuno, kunyanya mafomu ocular, anogona kubatsira (madonhwe eziso akanangana necorticosteroid inosanganiswa nemadonhwe eziso kudzora mwana wechikoro kuitira kudzivirira kusagadzikana kweiyo uveitis);
• muromo anticoagulants inoitirwa kutetepa ropa rinoshandiswa kurapa thrombosis.

Panguva imwecheteyo, zvinokurudzirwa kurega kuputa, fodya ichiva njodzi yekuwedzera kusagadzikana kwevascular. Kutora corticosteroids, kunyanya mune yakakwira doses, inofanirwa kuperekedzwa nechikafu chakaderera mushuga uye munyu. Pakaitika marwadzo akabatana, kudzidzira zvine mwero kusimbisa kurovedza muviri, kunze kwekusunda, kunogona kubatsira kuchengetedza kuchinjika kwemajoini uye musimba simba.

Chekupedzisira, sezvo chirwere chaBehçet chichigona kukonzera kushushikana uye shanduko yemunhu-chimiro, rutsigiro rwepfungwa runogona kubatsira kugamuchira zvirinani chirwere chako uye kurarama nacho pamwe nekugona zuva nezuva.