Ichi chirwere chisingatapuki chinoratidzirwa nekuumbwa kweprotein deposits iyo inoshandura kushanda kwemaitiro enhengo. Kazhinji kazhinji inofambira mberi kune fomu yakaoma uye inogona kukanganisa nhengo dzose. Hatinyatsozivi nhamba yevanhu vakabatwa nechirwere ichi chisingawanzoitiki muFrance, asi zvinofungidzirwa kuti chinobata munhu mumwe chete pavanhu 1. (100) Gore rega rega muFrance, zvakapoteredza 000 nyaya itsva dze AL amyloidosis dzinoonekwa. chimiro chisingawanzoitiki chechirwere.

Amyloidosis deposits inogona kuoneka munenge chero matishu uye nhengo mumuviri. Amyloidosis kazhinji inofambira mberi kusvika kune fomu yakaoma nekuparadza zvishoma nezvishoma nhengo dzakakanganisika: itsvo, mwoyo, chirwere chekudya uye chiropa ndiyo nhengo dzinowanzobatwa. Asi amyloidosis inogona kukanganisa mapfupa, majoini, ganda, maziso, rurimi ...

Naizvozvo, huwandu hwezviratidzo hwakakura kwazvo: kusagadzikana uye kupfupika kwekufema kana moyo uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchi buda , manyoka . itsvo. digestive tract, etc. Zviratidzo zvakakomba zvakadai sekupfupika kwekufema, manyoka uye kubuda ropa kunofanira kuchenjerera uye kutungamirira kuongororwa kweamyloidosis.

Amyloidosis inokonzerwa nekuchinja kwema molecular chimiro cheprotein, zvichiita kuti isanyungudika mumuviri. Protein inobva yaumba mamolecular deposits: the amyloid substance. Zvakarurama kutaura nezve amyloidosis kupfuura amyloidosis, nokuti kunyange zvazvo chirwere ichi chine chikonzero chimwe chete, matauriro ayo akasiyana zvikuru. Muchokwadi, anenge makumi maviri mapuroteni ane mutoro kune akawanda chaiwo mafomu. Zvisinei, marudzi matatu eamyloidosis anonyanya kukoshesa: AL (immunoglobulinic), AA (inflammatory) uye ATTR (transthyretin).

• AL amyloidosis inobva mukuwanda kwemamwe masero machena eropa (plasma cells). Ivo vanogadzira masoja ekudzivirira chirwere (immunoglobulins) ayo anounganidza uye kugadzira madhipoziti.
• AA amyloidosis inoitika apo kuzvimba kusingaperi kunokonzera kugadzirwa kwakanyanya kweSAA mapuroteni ayo anozogadzira amyloidosis mumatishu.
• Iyo transthyretin protein inobatanidzwa muATTR amyloidosis. Iyi fomu yechirwere ndeye genetic. Mubereki ane dambudziko ane 50% njodzi yekupfuudza shanduko kumwana wavo.

Amyloidosis haina kutapuriranwa. Epidemiological data inoratidza zvakajeka kuti njodzi inowedzera nezera (amyloidosis inowanzoongororwa makore anenge 60-70). Vanhu vane chirwere chinotapukira kana chekuzvimba, pamwe nevaya vakaita dialysis kwenguva refu, vari panjodzi. Sezvo mamwe maitiro e-amyloidosis, akadai seATTR amyloidosis, akabatanidzwa kune nhaka yekuchinja kwemajini, mhuri umo imwe kana nhengo dzakawanda dzakabatwa dzinofanira kunge dziri nyaya yekutariswa kwakakosha.

Kusvika iye zvino, hapana nzira yekudzivirira kurwisa amyloidosis. Kurapa kwese kunosanganisira kudzikisa kugadzirwa kweprotein ine muchetura iyo inoiswa uye yakaunganidzwa mumatishu, asi inosiyana zvichienderana nerudzi rweamyloidosis:

• ne chemotherapy munyaya ye AL amyloidosis. Mishonga yakashandiswa mukurapwa kwake inoratidza ” yekushanda chaiko », Inosimbisa National Society of Internal Medicine (SNFMI), ichitsanangura kuti kurwisa kwemwoyo kunoramba kwakakomba.
• kushandisa mishonga ine simba inorwisa-kuzvimba kurwisa kuzvimba kwakakonzera AA amyloidosis.
• Kune ATTR amyloidosis, kuisirwa kunogona kudikanwa kutsiva chiropa chakakomberedzwa neprotein ine chepfu.

The French Association against Amyloidosis inoburitsa ruzivo rwakawanda nezvechirwere ichi uye marapirwo acho, akaitirwa varwere nehama dzavo.