Endothelial dysfunction inoita basa rakakosha mukutanga kwezvirwere uye kunyanya chirwere chemoyo. Nzira yekutsanangura sei endothelium, chii basa rayo? Ndezvipi zvinhu zvine njodzi zvinotungamira kune endothelial dysfunction?

Iyo vascular endothelium inoumba cellular barriers pakati penyama neropa. Icho chinhu chakakosha mukugadzirisa kwevasomotor phenomena yevascular permeability, toni uye chimiro chemidziyo. Endothelial masero, mukupindura kune zvinokurudzira, anogadzira mamorekuru anotonga.

Kuti kuderedze njodzi yemoyo, iyo endothelium ndiyo inonyanya kukosha yekudzivirira uye yekurapa nhengo.

Pasi pesimba rekuchembera uye vascular risk factors, endothelium inogona kushandiswa uye kupinda maitiro ekugadzirisa izvo zvinogona kukanganisa basa iri, mumwe anobva ataura nezve "endothelial dysfunction".

Endothelial dysfunction inotsanangurwa sechinhu chisina kujairika mu endothelium-inotsamira vasodilation inokonzerwa nekuderera kuwanikwa kwezvinhu zvevasodilator, senge nitric oxide (NO), uye kuwedzera endothelial activation. Iyi activation inokonzeresa kuburitswa kwemamorekuru ekunamira kubva kuendothelium uye macrophages (masero emasero machena eropa, anopinda mukati mematishu. Munguva yethrombosis uye kuzvimba, mamorekuru aya anobatanidzwa mukutora leukocytes uye l platelet adhesion.

Pane zvechinyakare uye zvisiri zvechinyakare njodzi zvinhu.

Traditional ngozi zvinhu

Pakati pezvinhu zvechinyakare, endothelial kusagadzikana kunoonekwa kune varwere vane moyo nevascular risk factor, dyslipidemia, chirwere cheshuga, kukwira kweropa. Fodya, zera, uye nhaka zvinhuwo zvinofanira kufungwa nezvazvo.

Zvisiri zvechinyakare njodzi zvinhu

Pakati pezvinonzi zvinhu zvisiri zvechinyakare, pane kusaenzana mukugadzirwa kwevasodilator kana vasoconstrictor zvinhu zvinotungamirira kuchinjwa muhutano hwevasodilator ye endothelium, chiratidzo chikuru chekusagadzikana kwekupedzisira.

Endothelial basa, nekuda kwevasculoprotective mhedzisiro ye nitric oxide (NO), inodzivirira hutano hwemoyo.

Endothelial dysfunction chinhu chinozivisa kutanga kwezvimwe zvirwere:

• Zviitiko zvemwoyo;
• Insulin kuramba;
• Hyperglycemia;
• High blood pressure ;
• Dyslipidémie.

Mishonga inobatsira inosanganisira ma<em>statins, anoderedza cholesterol kunyange kana mwero we<em>cholesterol uri wenguva dzose kana kuti wakangokwidziridzwa zvishoma, uye pane dzimwe nguva aspirin kana kuti mamwe ma<em>antiplatelet zvinodhaka, zvinodhaka zvinodzivirira ma<em>platelet kuungana pamwe chete uye kuti asaumba kuvharika mutsinga dzeropa.

Mimwe mishonga inoshandiswa kurapa BP nemimwe inoshandiswa kurapa chirwere cheshuga inoderedzawo njodzi.

Nzira dzekuona endothelial dysfunction, invasive kana isiri-invasive, inoshanda kana biological, inzira dzemashoko anovandudza ruzivo rwehutano hwemwoyo uye hunobvumira, kusvika pamwero wakati, kuongorora kushanda kwemaitiro ekurapa. pamusoro pekufungidzira kwemamwe mapoka evarwere.

Muvanhu, endothelial dysfunction inogona kufungidzirwa nekuyera:

• Plasma concentrations ye metabolites ye dinitrogen monoxide (NO): chigadzirwa chisina kugadzikana kwazvo, hachikwanisi kutsanangurwa muropa, kune rumwe rutivi kugadziriswa kwemasabolites ayo (nitrites uye nitrate) inogoneka mumuguta;
• Plasma concentrations yeadhesion molecules: aya mamorekuru anotora chikamu muhutachiona hwehutachiona kuburikidza nekubvumira kusungirirwa kwe monocytes kune endothelium, zvino kutama kwavo mumadziro emukati emagetsi uye mitsipa;
• Matsotsi ekuzvidzivirira.

Mazhinji mabhaibheri mamaki anopupurirawo kune endothelial dysfunction. Yakanyanya kunzwa C-reactive protein (CRP) uye extracellular superoxide dismutase (ine simba enzyme system) iri pakati pavo.

Kudzivirira endothelial dysfunction, nzira dzakawanda dzakarongwa kusanganisira kudya. Basa rezvikafu zvinoumba senge fatty acids, antioxidant mavhitaminzi, folate, vhitamini D uye polyphenols inosimbiswa.

• Nhamba yakaderera yevhitamini D inotungamirira kune ngozi yakawanda yehutano hwemwoyo uye rudzi rwechirwere cheshuga 2;
• Oxidative kusagadzikana kunogona kukanganisa endothelial basa kuburikidza nekuzvimba uye kuderedzwa NO kuwanikwa;
• Lycopene, antioxidant ine simba, yaizoderedza zviratidzo zvekugadzirisa endothelium, reactive C protein, uye systolic blood pressure uye yaizova nemigumisiro inobatsira pakushungurudzika kweoxidative;
• Polyphenols inopiwa kunyanya nemichero, miriwo, cocoa, tii uye waini tsvuku. Kushandiswa kwavo kunobatanidza nengozi yakaderera yechirwere chemwoyo.