Iyo follicle stimulating hormone, kana FSH, ihomoni yakakosha yekubereka mune vese varume nevakadzi. Ichi ndicho chikonzero panguva yekuongorora mbereko, chiyero chayo chinotariswa zvakarongeka.

Mune vakadzi

HSF inoitika muchikamu chekutanga cheiyo ovarian cycle, inozivikanwa sefollicular phase. Munguva iyi, iyo inotanga pazuva rekutanga rekuenda kumwedzi uye inopera panguva yekuvhara, hypothalamus inobudisa neurohormone, GnRH (gonadotropin inobudisa hormone). A chain reaction ichatevera:

• GnRH inokurudzira pituitary gland, iyo mukupindura inobudisa FSH;
• pasi pesimba reFSH, anenge makumi maviri ovarian follicles anotanga kukura;
• aya mafollicles anokura achaitawo secrete estrogen, inokonzera kukora kweuterine lining kuitira kugadzirira chibereko kuti chigamuchire zai rinobvira;
• mukati meboka, follicle imwe, inonzi dominant follicle, inobudirira ovulation. Vamwe vachabviswa;
• apo iyo inotonga preovulatory follicle inosarudzwa, estrogen secretion inowedzera zvakanyanya. Kuwedzera uku kunokonzeresa kuvhiya kweLH (luteinizing hormone) izvo zvinozoita kuti ovulation: iyo yakakura follicle inotsemuka uye inoburitsa oocyte.

Pakati pekuita kweketani iyi, FSH ihomoni yakakosha yekuzvara.

Muvanhu

FSH inobatanidzwa muspermatogenesis uye secretion ye testosterone. Inokurudzira maseru eSertoli anoburitsa urume muma testes.

Mune vakadzi, chiyero cheFSH chinogona kurongerwa mumamiriro akasiyana:

• kana chiitiko chekutanga amenorrhea uye / kana kunonoka kuyaruka: kusanganiswa kweFSH neLH kunoitwa kuitira kusiyanisa pakati pekutanga (ovarian origin) kana yechipiri (yakakwirira mabviro: hypothalamus kana pituitary) hypogonadism;
• munyaya yechipiri amenorrhea;
• kana pakaitika dambudziko rekubereka, kuongororwa kwehomoni kunoitwa pamwe nechiyero chehomoni dzakasiyana dzepabonde: follicle stimulating hormone (FSH), estradiol, luteinizing hormone (LH), antimulleric hormone (AMH) uye mune dzimwe nguva prolactin, TSH (thyroid). ), testosterone. Kuongororwa kweFSH kunobatsira kuongorora ovarian reserve uye mhando yeovulation. Inobvumira kuziva kana ovulation disorder kana amenorrhea inokonzerwa nekukwegura kweovarian kana kuti pituitary gland kubatanidzwa.
• pakupera kwemwedzi, kutsunga kweFSH hakuchakurudzirwi kusimbisa kutanga kwepre-menopause uye menopause (HAS, 2005) (1).

Muvanhu

Kuongororwa kweFSH kunogona kuitwa sechikamu chekuongorora mbereko, pamberi peiyo spermogram abnormality (azoospermia kana yakanyanya oligospermia), kuitira kuongorora hypogonadism.

Miyero yeHormonal inotorwa kubva pakuongororwa ropa, kwete padumbu risina chinhu.

• muvakadzi, zvisungo zveFSH, LH uye estradiol zvinoitwa pazuva rechipiri, rechitatu kana 2 rekutenderera murabhoritari yereferensi.
• muvanhu, iyo FSH dosage inogona kuitwa chero nguva.

Muvakadzi:

• kuwedzera kwakajeka kweFSH neLH kunoratidza kukundikana kwekutanga ovarian;
• kuderera kukuru muLH neFSH kazhinji kunoratidza kukanganisa kwepituitary gland, yekutanga kana yechipiri (tumor, pituitary necrosis, hypophysectomy, nezvimwewo);
• kana FSH yakakwira uye / kana estradiol yakaderera, kuderera kweiyo ovarian reserve kunofungidzirwa ("kutanga kuenda kumwedzi").

Muvanhu:

• FSH yakakwirira inoratidza kukuvara kwe testicular kana seminiferous tubular;
• kana yakaderera, kubatanidzwa "kwakakwirira" (hypathalamus, pituitary) kunofungidzirwa. MRI uye kuongororwa kweropa kunopindirana kuchaitwa kutsvaga kusakwana kwepituitary.

Muvakadzi:

• muchiitiko chekukundikana kwe ovarian kana pituitary gland kubatanidzwa, ovarian stimulation treatment ichapiwa. Chinangwa chayo ndechekugadzira imwe kana maviri maoocyte akakura. Maprotocol akasiyana aripo, nenzira yemuromo kana majekiseni;
• muchiitiko chekusvika kusati kwasvika, mupiro weoocyte unogona kupihwa.

Muvanhu:

• muchiitiko che hypogonatotropic hypogonadism (kuchinjwa kwe hypotalamic-pituitary axis) neazoospermia yakaoma kana oligospermia, kurapwa kwekudzorera spermatogenesis kucharongwa. Mhando mbiri dzemamorekuru dzinogona kushandiswa: gonadotropins ine FSH chiitiko uye gonadotropins ine LH chiitiko. Iwo maprotocol, ayo anosiyana zvichienderana nemurwere, anopera 3 kusvika 4 mwedzi, kana kunyange kureba mune mamwe mamiriro.
• kana pakaitika shanduko huru yembeu uye imwe azoospermia (iyo zvinokwanisika kubvisa urume kubva mu epididymis kana testis), IVF ine ICSI inogona kupihwa. Iyi nzira yeAMP inosanganisira kubaya urume zvakananga mucytoplasm yeiyoocyte yakura;
• Kupihwa kwembeu kunogona kupihwa kune vakaroorana kana spermatogenesis isingagone kudzoreredzwa.