Rhabdomyolysis izwi rinowanzoratidza kuparadzwa kwetsandanyama. Pane zvikonzero zvakawanda zveiyi rhabdomyolysis, mhedzisiro yacho yakanyanya kana kushoma zvakanyanya zvichienderana nekwakabva chirwere.

Izwi rokuti rhabdomyolysis rinoumbwa nechivakashure -lyse chinoreva kuparadzwa, izwi rokuti rhabdomyo- kureva tsandanyama yeskeletal striated, kureva nyama dzese dzemuviri wemunhu kunze kwetsandanyama yemoyo (myocardium) nemhasuru dzakatsetseka (dzinoshandiswa. zveunyanzvi hwemotokari husingaite senge intestinal mota hunyanzvi kana iyo yetsinga dzeropa).

Kana masero emhasuru aparadzwa, mamorekuru mazhinji anoburitswa muropa. Imwe yeiyi enzyme inongowanikwa mumasero etsandanyama. Iyo creatine phosphokinase, inodaidzwa zvakanyanya seCPK. Iyi molecule inoedzwa mukuita kwazvino. Iyo yakakwirira iyo dosi, iyo yakakura rhabdomyolysis.

Zvikonzero zverhabdomyolysis zvakasiyana kwazvo. Tichatangazve pano runyorwa rusina kuperera rwezvikonzero zvinowanzoitika zverhabdomyolysis:

Trauma / compression

Kudzvinyirirwa kwenhengo, semuenzaniso crush syndrome, umo munhu anonamira pasi pemotokari kana pasi pemarara ekudengenyeka kwenyika, kunokonzera rhabdomyolysis iyo inowanzova yakaoma.

Kusagadzikana kwenguva refu kunokonzera kudzvinyirirwa kwemhasuru izvo zvinogona kutungamirira kurhabdomyolysis (kurasikirwa nekuziva, kuvhiyiwa kwenguva refu, nezvimwewo).

Kuwedzera kwetsandanyama kudhonzwa

• Dambudziko repfari
• Kunyanya kuita zvemitambo (marathon, Ultra-trail)

zvirwere

• Viral: furuwenza
• Utachiona: legionellosis, tularemia
• Parasitic: marariya, trichinellosis

Kupisa kwakanyanya

• Neuroleptic malignant syndrome
• Kupisa
• Yakashata hyperthermia

Toxic

• Doro
• Cocaine
• Heroin
• Amphetamines

Mishonga

• Neuroleptics
• Statins

Autoimmune

• Polymyosite
• Dermatomyosite

Genetics

Mune zvimwe zviitiko, mamiriro acho ezvinhu ari pachena, semuenzaniso panguva yekupwanya kwemakumbo kana kuti coma yakareba.

Mune zvimwe zviitiko, zviratidzo zvekuparadzwa kwemhasuru zvingava zvakaoma kuona. Marwadzo etsandanyama anogona kuve nekuoma-mhando kurwadziwa kana kurwadziwa kwemhasuru pane palpation. Panogona kunge paine tsandanyama edema iyo inogona kutungamirira kucompartment syndrome. Dzimwe nguva chiratidzo chetsandanyama chete kunzwa kwekuneta kwemhasuru.

Dzimwe nguva chiratidzo chechiremba kuchinja kwemuvara weti. Muchokwadi, iyo myoglobin inoburitswa nemhasuru masero mavara weti yakatsvuka ichichinja brown (kubva kuIce-Tea kuenda kuCoca-Cola).

Kuongororwa kwe rhabdomyolysis kunosimbiswa neCPK assay. Isu tinotaura nezve rhabdomyolysis kana maCPK akakwira zvakapetwa kashanu pane zvakajairika.

Dambudziko guru rerhabdomyolysis ndeye acute renal kukundikana. Izvi zvakasiyana-siyana asi tinocherechedza huturu hwemyoglobin uye kuunganidza kwayo mu renal tubules zvichiita kuti kuvharwe kwekuyerera kweweti. Kukundikana kwerenal kunogona kuperekedzwa nemamwe metabolic kusagadzikana kusanganisira hyperkalemia. Hyperkalemia ndiko kuwedzera kwe potassium muropa. Dambudziko iri rinogona kutungamirira kurufu kana potasium ikasadzoserwa kumazinga akajairika muropa nekukurumidza. Izvi zvinowanzoda kushandiswa kwedialysis.

Imwe mhedzisiro, yatatotaura ndeye compartment syndrome. Iko tension yezvikamu zvetsandanyama. Izvi zvinoratidzwa nekurwadziwa kwakanyanya uye edema inorwadza yemasuru. Kugadziriswa kwekuvhiya kunonzi "discharge aponeurotomy" kunofanira kuitwa nokukurumidza sezvinobvira, kana compartment syndrome ichisimbiswa.

Sezvataona kare, zvikonzero zverhabdomyolysis zvakasiyana-siyana. Kurapa zviri pachena kunoenderana nechinokonzera.

Kazhinji, kurapwa kwerhabdomyolysis kunoda kudzivirira matambudziko.

Kuti udzivise kutadza kwerenal kutadza, kudzoreredzwa kwemvura kwakaringana kunofanirwa kuve nechokwadi nekuti kupera simba kwemvura kuri panjodzi yekunetseka kwetsvo. Mumamiriro ezvinhu akaoma zvakakosha kutarisa nguva dzose kuti potassium muropa iri mukati memiganhu yakajairika. Pakupedzisira, kutarisisa kurwadziwa kwemhasuru kunoita kuti zvikwanise kuratidza compartment syndrome.

Mukupedzisa, tinogona kutsanangura kuti kune rhabdomyolysis uye rhabdomyolysis. Acute rhabdomyolysis nekudzvinyirirwa kwenhengo, semuenzaniso, inogona kutungamirira kurufu. Kusiyana neizvi, rhabdomyolysis panguva yefuru inongova "epiphenomenon" iyo pasina munhu achanetseka nayo. Zvirwere zvine hukama nerhabdomyolysis zvinoramba zvisingawanzo, kurovedza muviri zvakanyanya ndiko kwakajairika. Gara uchifunga nezvazvo uye uunze rhabdomyolysis pamberi pekurwadziwa kwetsandanyama kusina kujairika kana ruvara rutsvuku-ruvara rweweti.