Muna 1962, nyanzvi yezvesainzi yekuAmerica L. Hayflick akashandura ndima ye cell biology nekugadzira pfungwa yematelomere, inozivikanwa seHayflick limit. Maererano naHayflick, nguva yakawanda (inogoneka) yehupenyu hwevanhu ndeye zana nemakumi maviri emakore - iyi ndiyo nguva iyo masero akawanda haachakwanisi kupatsanura, uye chipenyu chinofa.
Iyo dhizaini inobata telomere kureba ndeyekudya kunobata telomerase, iyo enzyme inowedzera telomeric kudzokorora kusvika kumigumo yeDNA.
Zviuru zvezvidzidzo zvakatsaurirwa kune telomerase. Ivo vanozivikanwa nekuchengetedza genomic kugadzikana, kudzivirira kusingadiwe activation yeDNA kukuvara nzira, uye kudzora kuchembera kwesero.
Muna 1984, Elizabeth Blackburn, purofesa webiochemistry uye biophysics paYunivhesiti yeCalifornia kuSan Francisco, akawana kuti enzyme telomerase yakakwanisa kurebesa telomeres nekugadzira DNA kubva muRNA primer. Muna 2009, Blackburn, Carol Greider, naJack Szostak vakagamuchira Mubairo weNobel muPhysiology kana Mushonga wekuona kuti telomeres uye enzyme telomerase inodzivirira sei machromosomes.
Zvinogoneka kuti ruzivo rwematelomeres ruchatipa mukana wekuwedzera zvakanyanya tarisiro yehupenyu. Sezvingatarisirwa, vaongorori vari kugadzira mishonga yerudzi urwu, asi pane humbowo hwakawanda hwekuti mararamiro ari nyore uye kudya kwakakodzera kunoshandawo.
Izvi zvakanaka, nokuti ma telomeres mapfupi ane ngozi - haatungamiriri kurufu chete, asiwo kune zvirwere zvakawanda.
Saka, kupfupika kwetelomeres kunobatanidzwa nezvirwere, rondedzero yaro inopiwa pazasi. Zvidzidzo zvemhuka zvakaratidza kuti zvirwere zvakawanda zvinogona kubviswa nekudzorera telomerase basa. Uku kuderedzwa kwekudzivirira kwe immune system kune hutachiona, uye nyora XNUMX chirwere cheshuga, uye atherosclerotic kukuvara, pamwe neurodegenerative zvirwere, testicular, splenic, intestinal atrophy.
Imwe ongororo inokura inoratidza kuti zvimwe zvinovaka muviri zvinoita basa rakakosha mukudzivirira kureba kwetelomere uye zvine chekuita nehupenyu hurefu, kusanganisira iron, omega-3 mafuta, uye mavhitamini E uye C, vhitamini D3, zinc, vhitamini B12.
Pazasi pane tsananguro yezvimwe zvekudya izvi.
astaxanthin
Astaxanthin ine yakanakisa anti-kuzvimba mhedzisiro uye inodzivirira zvinobudirira DNA. Zvidzidzo zvakaratidza kuti inokwanisa kudzivirira DNA kubva pakukuvadzwa kunokonzerwa nemwaranzi ye gamma. Astaxanthin ine akawanda akasiyana hunhu anoita kuti ive musanganiswa wakasarudzika.
Semuenzaniso, ndiyo yakanyanya simba oxidizing carotenoid inokwanisa "kusuka" mahara radicals: astaxanthin inoshanda ka65 kupfuura vhitamini C, ka54 inoshanda kupfuura beta-carotene, uye ka14 inoshanda kupfuura vhitamini E. Iyo 550 nguva dzinoshanda kupfuura vhitamini E, uye ka11 dzinoshanda kupfuura beta-carotene mukuderedza singlet oxygen.
Astaxanthin inoyambuka zvese zveropa-uropi uye ropa-retinal barriers (beta-carotene uye iyo carotenoid lycopene haigone izvi), kuitira kuti uropi, maziso uye yepakati tsinga system igamuchire antioxidant uye anti-kuzvimba kudzivirira.
Chimwe chivakwa chinosiyanisa astaxanthin kubva kune mamwe macarotenoids ndechekuti haigone kuita seprooxidant. Mazhinji ma antioxidants anoita se pro-oxidants (kureva, anotanga kuita oxidize pachinzvimbo chekurwisa oxidation). Nekudaro, astaxanthin, kunyangwe muhuwandu hukuru, haiite seanoxidizing agent.
Chekupedzisira, chimwe chezvinhu zvakakosha zveastaxanthin kugona kwayo kwakasarudzika kuchengetedza yesero kubva pakuparadzwa: zvese zviri zviviri zvinonyungudika nemvura uye zvinonyungudika nemafuta. Mamwe ma antioxidants anokanganisa chimwe chete kana chimwe chikamu. Astaxanthin yakasarudzika hunhu hwemuviri inoibvumira kuti igare musero membrane, ichidzivirira mukati mesero zvakare.
Yakanakisa sosi yeastaxanthin ndeye microscopic alga Haematococcus pluvialis, inokura muSweden archipelago. Mukuwedzera, astaxanthin ine yakanaka yekare blueberries.
ubiquinol
Ubiquinol inzira yakaderedzwa yeubiquinone. Muchokwadi, ubiquinol ndeye ubiquinone iyo yakanamatira hydrogen molecule pachayo. Inowanikwa mu broccoli, parsley uye maranjisi.
Zvikafu zvakaviriswa / Probiotics
Zviri pachena kuti kudya kunosanganisira kunyanya kudya kwakagadzirwa kunopfupisa nguva yekurarama. Vatsvakurudzi vanotenda kuti muzvizvarwa zvinotevera, kuchinja kwemajini akawanda uye kusagadzikana kwekushanda kunotungamirira kuzvirwere zvinogoneka - nokuda kwechikonzero chekuti chizvarwa chemazuva ano chinoshingaira kudya zvokudya zvekugadzira uye zvakagadzirwa.
Chikamu chechinetso ndechekuti zvikafu zvakagadziriswa, zvakatakurwa neshuga nemakemikari, zvinobudirira pakuparadza gut microflora. Iyo microflora inokanganisa immune system, inova gadziriro yemuviri yekudzivirira. Mishonga inorwisa mabhakitiriya, kushushikana, zvinotapira zvekugadzira, mvura yeklorini, uye zvimwe zvinhu zvakawanda zvakare zvinoderedza huwandu hweprobiotics muura, izvo zvinotungamira muviri kuchirwere uye kuchembera nguva isati yakwana. Sezvineiwo, kudya kunofanirwa kusanganisira chikafu chakarimwa uye chakaviriswa.
Vhitamini K2
Iyi vhitamini inogona chaizvo kuve "imwe vhitamini D" sezvo tsvakiridzo inoratidza vhitamini ine hutano hwakawanda. Vanhu vazhinji vanowana huwandu hwakakwana hwevhitamini K2 (nokuti inogadzirwa nemuviri mudumbu diki) kuchengetedza ropa richibatana pamwero wakakwana, asi chiyero ichi hachina kukwana kudzivirira muviri kubva kumatambudziko akakomba ehutano. Somuenzaniso, ongororo dzakaitwa mumakore achangopfuura dzinoratidza kuti vhitamini K2 inogona kudzivirira muviri pagomarara reprostate. Vitamin K2 inobatsirawo kune hutano hwemoyo. Iri mumukaka, soy (muhuwandu - mu natto).
Magnesium
Magnesium inoita basa rakakosha mukuberekazve kweDNA, kudzoreredza kwayo uye kuumbwa kwe ribonucleic acid. Kushaikwa kwenguva refu kwemagesium kunoguma nekupfupikiswa kwema telomere mumitumbi yemakonzo uye muchitokisi tsika. Kushaikwa kwe magnesium ions kunokanganisa hutano hwemajini. Kushaikwa kwemagnesium kunoderedza kugona kwemuviri kugadzirisa DNA yakakanganisika uye kukonzeresa kusagadzikana mumakromosomes. Kazhinji, magnesium inokanganisa kureba kwetelomere, sezvo ichibatanidzwa nehutano hweDNA uye kugona kwayo kuzvigadzirisa, uye inowedzera kuramba kwemuviri kune oxidative kusagadzikana uye kuzvimba. Inowanikwa muspinachi, asparagus, gorosi bran, nzungu nemhodzi, bhinzi, maapuro egirini uye lettuce, uye mhiripiri.
Polyphenols
Polyphenols ane simba antioxidants anogona kudzikamisa maitiro.