Uropi hunoparadzaniswa nemuviri wese neropa-brain barrier. Mavhairasi anoyambuka sei chipingamupinyi cheropa-uropi kuti asvike pakati penheyo system? Ko chipingamupinyi chehuropi hweropa chinoshanda sei?

Ropa-brain chipingamupinyi chidziviso chakasarudzika chine basa guru rekuparadzanisa central nerve system (CNS) kubva muropa. Nzira yaro inoita kuti zvikwanise kunyatso kudzora kuchinjana pakati peropa uye cerebral compartment. Iyo yeropa-brain chipingamupinyi saka inoparadzanisa huropi kubva kune yese yemuviri uye inopa iyo chaiyo nharaunda, yakasiyana nemukati nharaunda yeimwe yese yemuviri.

Ropa-brain barriers ine yakakosha kusefa zvinhu izvo zvinoibvumira kudzivirira zvinogona kuita chepfu kunze kuti zvipinde muuropi nemuzongoza.

Iyi hemoencephalic barriers, nekuda kwesefa yayo yakasarudzika, inogona kubvumira mafambiro emvura, mamwe magasi uye liposoluble mamorekuru kuburikidza ne passive diffusion, pamwe nekusarudzika kutakura kwemamorekuru akadai seglucose uye amino acids anoita basa. yakakosha mukuita neuronal uye kudzivirira kupinda kweanogona lipophilic neurotoxins, kuburikidza neinoshingaira glycoprotein-mediated transport mechanism.

Astrocytes (inobatsira kuchengetedza kemikari uye nharaunda yemagetsi nekupa chikafu chinodiwa kuuropi nekubvisa tsvina yavo) yakakosha mukugadzira chipingamupinyi ichi.

Ropa-brain barriers inodzivirira huropi kubva kune chepfu uye nhume dzinotenderera muropa.

Uyezve, basa iri rakapetwa kaviri, nekuti rinodzivirirawo kupinda kwemamorekuru nekuda kwekurapa.

Mamwe mavhairasi anogona kuramba achipfuura chipingamupinyi ichi kuburikidza neropa kana ne "retrograde axonal" yekufambisa. Kuvhiringidzika kweropa-brain barriers kunokonzerwa nezvirwere zvakasiyana-siyana.

Neurodegenerative hosha

Nekuda kwekuita kwayo kwakakosha mukuchengetedza cerebral homeostasis, iyo yeropa-brain barriers inogona zvakare kuve kutanga kwezvimwe zvirwere zvetsinga senge neurodegenerative chirwere uye maronda ehuropi akadai sechirwere cheAlzheimer (AD) asi izvo zvinoramba zvisingawanzo. .

Diabetes mellitus

Zvimwe zvirwere, zvakadai sechirwere cheshuga mellitus, zvinewo kukanganisa kwekuchengetedza kweropa-brain barrier.

Humwe hutachiona

Zvimwe zvirwere, kune rumwe rutivi, zvinokanganisa basa re endothelium kubva mukati, kureva, iyo yose yeropa-brain barriers inokuvadzwa nezviito kubva kune extracellular matrix.

Kusiyana neizvi, huwandu hwehosha dzehuropi hunoratidzwa nenyaya yekuti mamwe hutachiona hunogona kuyambuka ropa-brain chipingamupinyi zvichikonzera hutachiona hwehuropi izvo zviri hosha dzinoparadza dzinoperekedzwa nekufa kwakanyanya kana kune vanopona zvakanyanya neurological sequelae. Izvi zvinosanganisira, semuenzaniso, zvakasiyana-siyana zvepathogenic microorganisms, mabhakitiriya, fungi, hutachiona hweHI, munhu T-lymphotropic virus 1, utachiona hweWest Nile uye mabhakitiriya, akadai seNeisseria meningitidis kana Vibrio cholerae.

Mumultiple sclerosis, “matachiona” maseru edziviriro yemuviri anoyambuka chipingamupinyi cheropa-uropi.

Metastatic masero anobudirira kuyambuka ropa-brain barriers mune mamwe asiri europi tumors uye anogona kukonzera metastases muuropi (glioblastoma).

Kupa mishonga kuuropi nekuyambuka chivharo cheropa-uropi rwendo rwechokwadi nokuti inodzivirirawo kuwanikwa kwemishonga, kunyanya iyo ine hukuru hwema molecular, kune nzvimbo inoda kurapwa.

Mimwe mishonga yakaita seTemozolomide, inoshandiswa kurwisa glioblastoma ine makemikari uye emuviri zvinhu zvinoibvumira kupfuura chipingamupinyi uye kusvika pabundu.

Imwe yemikana yakaongororwa mukuedza kupedza dambudziko iri ndeyekushandisa nzira dzinogona kupinza nemuchina chivharo cheropa-uropi.

Ropa-uropi chipingamupinyi chikuru chipingamupinyi pakurapwa, asi tsvakiridzo irikuenderera mberi.

Chigadzirwa chekutanga chekusiyanisa chakagadzirwa cheMRI chaive gadolinium (Gd) uyezve Gd-DTPA77, izvo zvakaita kuti zvikwanise kuwana maMRIs epamusoro ekuongororwa kwezvironda zvepanzvimbo yeropa-brain barrier. Iyo Gd-DTPA Morekuru haipindike zvakanyanya kuyambuka chivharo chine hutano cheropa-uropi.

Dzimwe nzira dzekufungidzira

Kushandiswa kwe "single-photon emission tomography" kana "positron emission tomography".

Kukanganisika muvharidziro yehuropi hweropa kunogona zvakare kuongororwa nekuparadzirwa kweiyo yakakodzera midhiya yekusiyanisa uchishandisa computed tomography.